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Testing of Drugs for Nephrotoxicity General Principles and Minimal Criteria

  • H. Bräunlich
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 4)

Abstract

A programme for testing of drugs for nephrotoxicity is described. The characterization of nephrotoxic effects is possible using a selection of morphological and physiological methods. The validity of the different methods is discussed. The measurement of renal enzyme excretion is a very sensitive method for the detection of an injury of kidney. Alterations of renal excretion of electrolytes and p-aminohippurate can be measured in a simple diuresis study.

Key words

Nephrotoxicity Testing methods Urinary sediment Enzymuria Renal excretion 

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References

  1. Bräunlich, H.: Methods for testing of nephrotoxic agents. Zbl. Pharm. 114, 605–619 (1975)Google Scholar
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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • H. Bräunlich
    • 1
  1. 1.Institute of Pharmacology and ToxicologyFriedrich-Schiller-University JenaJenaGDR

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