Digitoxin in Renal Failure, Pro and Contra

  • L. Storstein
Conference paper

Abstract

In his “An account of the foxglove” William Withering [1] wisely remarked:

“It is much easier to write upon a disease than upon a remedy. The former is in the hands of Nature and a faithful observer with an eye of tolerable judgement cannot fail to delineate a likeness. The latter will ever be subject to the whim, the inaccuracies and the blunder of mankind.”

Medical communication could be fast even in those days; in the year following its publication in Birmingham, a German doctor in Leipzig, Christian Friederich Michaelis, translated Witherings work to German.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Withering W (1875) An account of the foxglove. Swinney, BirminghamGoogle Scholar
  2. 2.
    Storstein L (1976) Studies on digitalis. V. The influence of impaired renal function: hemodialysis and drug interaction on serum protein binding of digitoxin and digoxin. Clin Pharmacol Ther 20:6–14PubMedGoogle Scholar
  3. 3.
    Peters U, Grabensee B, Hausamen TU, Fritsch WR, Grosse-Brochoff F (1977) Pharmakokinetik von Digitoxin bei chronischer Niereninsuffizienz. Dtsch Med Wochenschr 102:109–115PubMedCrossRefGoogle Scholar
  4. 4.
    Storstein L (1976) Studies on digitalis. VII. The influence of nephrotic syndrome on protein binding, pharmacokinetics and renal excretion of digitoxin and cardioactive metabolites. Clin Pharmacol Ther 20:158–166PubMedGoogle Scholar
  5. 5.
    Storstein L (1976) Studies on digitalis. VI. The effect of heparin administration on serum protein binding of digitoxin and digoxin. Clin Pharmacol Ther 20:15–23PubMedGoogle Scholar
  6. 6.
    Storstein L, Nitter-Hauge S, Fjeld N (1979) Effect of cardiopulmonary by-pass with heparin administration on digitoxin pharmacokinetics, serum electrolytes, free fatty acids and renal function. Cardiovasc Pharmacol 1:191–205CrossRefGoogle Scholar
  7. 7.
    Storstein L (1974) Studies on digitalis. II. The influence of impaired renal function on the renal excretion of digitoxin and cardioactive metabolites. Clin Pharmacol Ther 16:25–35PubMedGoogle Scholar
  8. 8.
    Storstein L (1977) Studies on digitalis. XI. Digitoxin metabolism in patients with impaired renal function. Clin Pharmacol Ther 21:536–546PubMedGoogle Scholar
  9. 9.
    Bodem G, Unruh E von (1978) Dihydrodigitoxin, a metabolite of digitoxin in humans. In: Bodem G, Dengler HJ (ed) Cardiac glycosides. Springer, Berlin Heidelberg New York pp. 74–84Google Scholar
  10. 10.
    Rasmussen K, Jervell J, Storstein L, Gjerdrum K (1972) Digitoxin kinetics in patients with impaired renal function. Clin Pharmacol Ther 13:6–14PubMedGoogle Scholar
  11. 11.
    Vöhringer HF (1979) Renale und extrarenale Elimination von Digitoxin. In: Rietbrock N, Greeff K (ed) Digitoxin als Alternative in der Therapie der Herzinsuffizienz F.K. Schattauer Verlag. Stuttgart — New York pp. 114–126Google Scholar
  12. 12.
    Kramer P, Horenkamp J, Willins B, Scheler F (1970) Das Kumulationsverhalten verschiedener Herzglykoside bei Anurie. Dtsch Med Wochenschr 95:444–453PubMedCrossRefGoogle Scholar
  13. 13.
    Beller GA, Smith TW, Abelmann WH, Haber E, Hood WB jr (1971) Digitalis intoxication. A prospective clinical study with serum level correlations. N Engl J Med, 284:989–997PubMedCrossRefGoogle Scholar
  14. 14.
    Storstein O, Hansteen V, Hatle L, Hillestad L, Storstein L (1977) Studies on digitalis. XIII. A prospective study of 649 patients on maintenance treatment with digitoxin. Am Heart J 93:434–443PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • L. Storstein
    • 1
  1. 1.OsloNorwegen

Personalised recommendations