Regional Wall Motion Following Intra-Bypass Injection of Nifedipine: Design of a Protocol and Initial Experience

  • P. W. Serruys
  • M. v. d. Brand
  • H. J. ten Katen
  • R. W. Brower
Conference paper

Abstract

It still remains unclear whether Nifedipine at therapeutic dosages has a direct inotropic effect on the myocardium or whether the change in function is the result of changes in loading conditions [1,2,3]. Kaltenbach and his group have demonstrated that intracoronary injections provoke practically no changes in heart rate, but a small drop in aortic pressure [4]. This result has been attributed to a direct and specific negative inotropic action of the drug independent of a vasodilator effect at the periphery.

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Copyright information

© Springer-Verlag Berlin-Heidelberg 1980

Authors and Affiliations

  • P. W. Serruys
  • M. v. d. Brand
  • H. J. ten Katen
  • R. W. Brower

There are no affiliations available

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