Progress in Multiple Sclerosis Research pp 304-309 | Cite as
The Enhancing Effect of Multiple Sclerosis Brain Homogenates on Active E-Rosette Forming Lymphocytes in Neurological Disorders. Relationship Between Rosette Formation and Clinical Parameters
Conference paper
Abstract
Our recent studies [3] have described the enhancing effect of multiple sclerosis (MS) brain homogenates on the active E-rosette forming lymphocytes from MS patients. In this assay, antigen-sensitive T cells are measured by in vitro exposure of lymphocytes to brain homogenates prepared from MS and control brains. Since the increase in active E rosettes after antigenic stimulation is indicative of the sensitivity to the antigen [1], our data revealed MS lymphocytes to be sensitive to MS brain homogenates.
Keywords
Multiple Sclerosis Multiple Sclerosis Patient Brain Homogenate Vertical Plate Multiple Sclerosis Case
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References
- 1.Felsburg PJ, Edelman R (1977) The active E-rosette Test: A sensitive in vitro correlate for human delayed-type hypersensitivity. J Immunol 118:62–66Google Scholar
- 2.McAlpine D, Lumsden CE, Acheson ED (1965) Multiple sclerosis: A reappraisal. Livingstone, London, pp 142–178Google Scholar
- 3.Offner H, Rastogi SC, Konat G, Clausen J (1979) The enhancing effect of multiple sclerosis brain homogenates on the active E rosette forming lymphocytes. J Neurol 42:349–355Google Scholar
- 4.Zielhuis RL, Verberk MM (1974) Validity of biological tests in epidemiological toxicology. Int Arch Arbeitsmed 32:167–190PubMedCrossRefGoogle Scholar
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© Springer-Verlag Berlin Heidelberg 1980