Defective Viral Infection: The Rescue of Virus from Antigen-Negative Cells

  • S. A. Stohlman
  • A. Y. Sakaguchi
  • L. P. Weiner
Conference paper


There is epidemiologic evidence for a viral infection in multiple sclerosis (MS). Over the years, frequent attempts to rescue virus and demonstrate viral antigens in the brain of MS patients have failed. There have been a number of isolates, but none have been found to play a role in the etiology of the disease. We have been studying an animal model of viral-induced acute and chronic demyelination. The virus, a mouse coronavirus, JHM, is a neurotropic strain of mouse hepatitis virus. In order to better understand JHM virus chronic infection, we have developed an in vitro carrier culture system of persistently infected mouse neuroblastoma cells [6].


Multiple Sclerosis Multiple Sclerosis Patient Neuroblastoma Cell Viral Antigen Infectious Virus 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • S. A. Stohlman
    • 1
    • 2
  • A. Y. Sakaguchi
    • 3
  • L. P. Weiner
    • 1
    • 2
  1. 1.Department of Neurology, School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Department of Microbiology, School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  3. 3.Biochemical Genetics SectionRoswell Park Memorial InstituteBuffaloUSA

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