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Defective Viral Infection: The Rescue of Virus from Antigen-Negative Cells

  • S. A. Stohlman
  • A. Y. Sakaguchi
  • L. P. Weiner
Conference paper

Abstract

There is epidemiologic evidence for a viral infection in multiple sclerosis (MS). Over the years, frequent attempts to rescue virus and demonstrate viral antigens in the brain of MS patients have failed. There have been a number of isolates, but none have been found to play a role in the etiology of the disease. We have been studying an animal model of viral-induced acute and chronic demyelination. The virus, a mouse coronavirus, JHM, is a neurotropic strain of mouse hepatitis virus. In order to better understand JHM virus chronic infection, we have developed an in vitro carrier culture system of persistently infected mouse neuroblastoma cells [6].

Keywords

Multiple Sclerosis Multiple Sclerosis Patient Neuroblastoma Cell Viral Antigen Infectious Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1980

Authors and Affiliations

  • S. A. Stohlman
    • 1
    • 2
  • A. Y. Sakaguchi
    • 3
  • L. P. Weiner
    • 1
    • 2
  1. 1.Department of Neurology, School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Department of Microbiology, School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  3. 3.Biochemical Genetics SectionRoswell Park Memorial InstituteBuffaloUSA

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