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Detectors

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High Performance Liquid Chromatography

Part of the book series: Chemical Laboratory Practice ((CHEMICAL LABORA))

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Abstract

The composition of the column effluent is continuously monitored by a detector. Unfortunately, there is still no universally applicable LC detector. The physicochemical properties of the mobile phase differ very little from those of the sample components, thus requiring either very specific detectors (such as a UV detector) or those capable of measuring extremely small differences in the bulk properties by a differential technique (such as a differential refractometer). A suitable detector must be selected for each sample-eluent combination. Therefore, at least two different detectors should be available for each instrument. One of them should be a differential detector that responds to the bulk properties of the eluent (e.g., refractometer, dielectric constant) and the other should be specific in its response to the substances being monitored. The latter type includes the UV as well as Polarographic and radioactivity detectors. The more specific the detector becomes the more one is restricted in the choice of the mobile phase.

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  1. Angewandte Physikalische Chemie, Universität des Saarlandes, D-6600, Saarbrücken, Germany

    Heinz Engelhardt

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  1. Heinz Engelhardt
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© 1979 Springer-Verlag Berlin · Heidelberg

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Engelhardt, H. (1979). Detectors. In: High Performance Liquid Chromatography. Chemical Laboratory Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67064-0_4

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  • DOI: https://doi.org/10.1007/978-3-642-67064-0_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67066-4

  • Online ISBN: 978-3-642-67064-0

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