Relationships Between Doses, Plasma Levels and Cardiac Effects Under Digitalis Treatment

Apter, L., Ashman, R., Hull, E.: A quantitative study of the effects of ouabain upon the electrocardiogram. J. Pharmacol. Exp. Ther. 82, 227–238 (1944)Google Scholar

Aravanis, C., Luisada, A.A.: Clinical comparison of six digitalis preparations by the parenteral route. Am. J. Cardiol. 1, 706–716 (1958)PubMedCrossRefGoogle Scholar

Bazett, H.C.: An analysis of the time relations of the electrocardiogram. Heart 7, 353–370 (1920)Google Scholar

Belz, G.G., Stauch, M., Belz, G., Kurbjuweit, H.G., Oberdorf, A.: The effect of various cardenolides and bufadienolides with different cardiac activity on the ⁸⁶Rubidium-uptake of human erythrocytes. Naunyn Schmiedebergs. Arch. Pharmakol. 280, 353–362 (1973)CrossRefGoogle Scholar

Belz, G.G., Stauch, M., Rudofsky, G.: Plasma levels after a single oral dose of proscillaridin. Eur. J. Clin. Pharmacol. 7, 95–97 (1974)PubMedCrossRefGoogle Scholar

Belz, G.G., Erbel, R., Schumann, K., Gilfrich, H.J.: Dose — effect — plasma concentration relations of digitalis glycosides in man. Europ. J. Clin. Pharmacol, (in press)Google Scholar

Blumberger, K.J.: Die Untersuchung der Dynamik des Herzens beim Menschen. Ihre Anwendung als Herzleistungsprüfung. Ergeb. Inn. Med. Kinderheilk. 62, 424–531 (1942)Google Scholar

Brecht, K., Boucke, H.: Neues elektrostatisches Tiefton-Mikrophon und seine Anwendung in der Sphygmographie. Pflügers Arch. 256, 43–54 (1952)PubMedCrossRefGoogle Scholar

Fingl, E., Woodbury, D.M.: General Principles. In: The Pharmacological Basis of Therapeutics, 5th ed. Goodman, L.S., Gilman, A., (eds.) New York: Mac Millan 1975, p. 25Google Scholar

Flasch, H.: Die biologische Verfügbarkeit von β-Acetyldigoxin and Digoxin. Klin. Wochenschr. 53, 873–877 (1975)PubMedCrossRefGoogle Scholar

Goth, A.: Medical Pharmacology, 6th ed. Saint Louis: C.V. Mosby 1972, p. 8Google Scholar

Goth, A.: Medical Pharmacology, 6th ed. Saint Louis: C.V. Mosby 1972, p. 370Google Scholar

Greeff, K., Schlieper, E.: Artspezifische Wirkungsunterschiede des k-Strophanthins und Prednisolonbisguanylhydrazons: Untersuchungen an isolierten Vor-hofpräparaten und Erythrozyten des Menschen, Meerschweinchens und der Ratte. Arch. Int. Pharmacodyn. Ther. 166, 350–361 (1967)PubMedGoogle Scholar

Kwee, H.G., Ulex, G.A.: Die Bestimmung der Auflösungsgeschwindigkeit mit einer neuen Durchflußzelle. Pharm. Ind. 36, 576–582 (1974)Google Scholar

Lowenstein, J.M.: A method for measuring plasma levels of digitalis glycosides. Circulation 31, 228–233 (1965)PubMedGoogle Scholar

Matos, L., Bekés, M., Polák, G., Rausch, J., Török, E.: Comparative study of the cardiac and peripheral vascular effects of strophanthin K and lanatoside C in coronary heart disease. Eur. J. Clin. Pharmacol, 9, 27–37 (1975)PubMedCrossRefGoogle Scholar

Moe, G.K., Farah, A.E.: Digitalis and allied cardiac glycosides. In: The Pharmacological Basis of Therapeutics, 5th ed. Goodman, L.S., Gilman, A. (eds.) New York: Mac Millan 1975, p. 675Google Scholar

Nehb, W.: Zur Standardisierung der Brustwandableitungen des Elektrokardiogramms. Klin. Wochenschr. 17, 1807–1811 (1938)CrossRefGoogle Scholar

Ruiz-Torres, A., Burmeister, H.: Stoffwechsel und Kinetik von β-Acetyldigoxin. Klin. Wochenschr. 50, 191–195 (1972)PubMedCrossRefGoogle Scholar

Weber, E.: Grundriß der biologischen Statistik, 6th ed. Stuttgart: G. Fischer 1967Google Scholar

Weissler, A.M., Harris, W.S., Schoenfeld, C.D.: Systolic time intervals in heart failure in man. Circulation 37, 149–159 (1968)PubMedGoogle Scholar

Weissler, A.M., Schoenfeld, C.D.: Effect of digitalis on systolic time intervals in heart failure. Am. J. Med. Sci. 259, 4–20 (1970)PubMedCrossRefGoogle Scholar

Weissler, A.M., Snyder, J.R., Schoenfeld, C.D., Cohen, S.: Assay of digitalis glycosides in man. Am. J. Cardiol. 17, 768–780 (1966)CrossRefGoogle Scholar