The Metabolic Effects of Anabolic Steroids in Man

  • R. L. Landau
Chapter
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 43)

Abstract

Several clinical observations anticipated the experimental demonstration that male hormone is a growth promoting agent. In 1895 Sacchi described a 9-year-old boy who started growing very rapidly at the age of 5. He was 4 ft 9 in tall and weighed 97 lb, exceeding the height and weight of the average American 9-year-old by 6 in and 30 lb. He also exhibited a deep beard and masculine body hair. These were the clinical expressions of a 289-g interstitial cell tumor of the testis. Ten months after removal of the tumor the virilizing process had subsided and the physical state was reported to be essentially unchanged. In 1929 Rowlands and Nicholson, described another virilized 9-year-old boy who had grown unusually rapidly for 3 years. He was 5 ft tall and quite muscular. A large interstitial cell tumor was also removed in this case and rapid growth stopped after the surgery. A third case of this sort, a 5-year-old, was described by Stewart et al. (1936). This patient was 51 in tall, 5 in taller than the American average, and was beginning to virilize. The interstitial cell tumor in this case measured 1 cm in diameter. These case reports comprise the evidence available indicating the anabolic influence of testicular androgen when testosterone became available for clinical study. Since then there have, of course, been other reports.

Keywords

Metabolic Effect Chorionic Gonadotropin Anabolic Steroid Anabolic Effect Anabolic Agent 
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