Physiological and Biochemical Findings in the Central Nervous System of Adrenalectomized Rats and Mice

  • Alexander Baethmann
  • Anthonie Van Harreveld


Adrenalectomy produces in rats and mice a water and Na+ accumulation in the CNS which is similar to changes found in metabolic forms of brain edema. In adrenalectomized animals the cerebral water content is in close correlation with the tissue/plasma Na+- and K+-concentration gradient and, furthermore, appears to be a function of the external sodium supply. Impedance measurements and results obtained from electron-microscopy suggest that the fluid is not intracellularly localized but probably distributes within the extracellular space. Tissue concentration levels of energy-rich phosphate compounds or of lactate and pyruvate revealed no changes after adrenalectomy. Changes of metabolic activity as demonstrated by a decreased activity of NADP-dependent ICDH, GLDH and GOT may, however, participate in the mechanisms which produce the cerebral Na+ and water influx.


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Copyright information

© Springer-Verlag Berlin · Heidelberg 1972

Authors and Affiliations

  • Alexander Baethmann
    • 1
    • 2
  • Anthonie Van Harreveld
    • 1
    • 2
  1. 1.Institute for Surgical Research, Dept. SurgeryUniversity MunichGermany
  2. 2.Division of BiologyCalifornia Institute of TechnologyPasadenaUSA

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