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Biomembranes pp 160-176 | Cite as

The Role of the Na+/K+ Pump in Normal and Cancer Cell Proliferation

  • Kurt R. H. Repke

Abstract

The well-characterized basic functions of the Na+/K+ pump include: (1) maintenance of the transmembrane Na+ and K+ gradients over the plasma membrane, which is a prerequisite for the generation of the resting membrane potential and the action potential; (2) generation of the transmembrane electrochemical potential gradient for Na+ ions which provides the energy for the uphill movements of H+ and Ca2+ ions as well as sugars and amino acids through the appropriately coupled transfer devices; (3) maintenance of the high [K+] environment which is required for the optimum activity of many intracellular enzymes involved in energy generation and macromolecule synthesis. In the outcome, the Na+/K+ pump plays a key role in the regulation of normal cellular homeostasis, cell differentiation and cell proliferation.

Keywords

Pump Power Growth Promoter Cancer Cell Proliferation Pump Molecule Macromolecule Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Kurt R. H. Repke
    • 1
  1. 1.Energy Conversion Unit, Central Institute of Molecular BiologyAcademy of Sciences of GDRBerlinGermany

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