Biomembranes pp 160-176 | Cite as

The Role of the Na+/K+ Pump in Normal and Cancer Cell Proliferation

  • Kurt R. H. Repke


The well-characterized basic functions of the Na+/K+ pump include: (1) maintenance of the transmembrane Na+ and K+ gradients over the plasma membrane, which is a prerequisite for the generation of the resting membrane potential and the action potential; (2) generation of the transmembrane electrochemical potential gradient for Na+ ions which provides the energy for the uphill movements of H+ and Ca2+ ions as well as sugars and amino acids through the appropriately coupled transfer devices; (3) maintenance of the high [K+] environment which is required for the optimum activity of many intracellular enzymes involved in energy generation and macromolecule synthesis. In the outcome, the Na+/K+ pump plays a key role in the regulation of normal cellular homeostasis, cell differentiation and cell proliferation.


Pump Power Growth Promoter Cancer Cell Proliferation Pump Molecule Macromolecule Synthesis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Kurt R. H. Repke
    • 1
  1. 1.Energy Conversion Unit, Central Institute of Molecular BiologyAcademy of Sciences of GDRBerlinGermany

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