Effects of Radiation on the Plasma Membrane and Expression of Membrane Bound Hematopoietic Cytokines

  • Nicholas Dainiak
  • Joseph Albanese
Conference paper
Part of the NATO ASI Series book series (volume 94)

Abstract

The plasma membrane is a dynamic organelle whose components are continually turned over. Proteins and lipids are synthesized and inserted into the plasma membrane where they reside for a finite time period, after which they are internalized or exfoliated from the cell surface. The release of plasma membrane constituents in association with vesicles exfoliated from the cell surface is reduced by exposure to ultraviolet radiation. Moreover, the expression of membrane-bound cytokines on the cell surface and on extracellular vesicles is also impaired by ultraviolet light treatment. These results are discussed in the context of radiation-induced alterations in the structure and function of plasma membrane components, and with respect to radiation-induced apoptotic cell death.

Keywords

Chinese Hamster Ovary Cell Basic Fibroblast Growth Factor Irradiate Cell Extracellular Vesicle Royal Victoria Hospital 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Nicholas Dainiak
    • 1
  • Joseph Albanese
    • 1
  1. 1.Department of Medicine, Royal Victoria HospitalMcGill University, MontrealQuebecCanada

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