Molecular Biology of Hepatic Drug Reactions

  • R. W. Sallie
  • E. A. Jones
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 121)

Abstract

In a very real sense, the burgeoning discipline of “molecular biology”, broadly defined, can be gainfully applied in most fields of medicine, including those relevant to the topics covered in the majority of chapters in this volume. Various aspects of the molecular biology of hepatic drug reactions, particularly those pertaining to cell damage mediated by lipid peroxidation, glutathione depletion and genetic susceptibility, are covered by other authors. This chapter is concerned predominantly with a theoretical discussion of hepatic drug reactions which are mediated, at least in part, hy interference with the metabolism and processing of DNA or RNA and with the synthesis of proteins. Hepatocellular apoptosis is also discussed in this context. Wherever possible, the discussion indicates how mechanism(s) relate to overt liver disease in patients. Much of the work conducted to investigate mechanisms of drug toxicity has been carried out in animal models or in vitro systems using cultures of non-hepatocyte cell lines. The limitations and pitfalls of extrapolating from non-human data to the clinical situation are well recognised.

Keywords

Primary Biliary Cirrhosis Nucleoside Analogue Vinyl Chloride Monomer Nascent Chain Halothane Hepatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • R. W. Sallie
  • E. A. Jones

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