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Use of Complex Carbohydrates as Targets and Ligands for Imaging

  • R. Tauber
  • S. Emig
  • B. Volz
  • C. Fieger
  • C. Bührer
Conference paper
  • 35 Downloads
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 22)

Abstract

Complex carbohydrates were long considered to be biological compounds that lack any biological specificity, serving merely as structural components of cells, of the extracellular matrix, and of connective tissues, as mucins on epithelial surfaces, or as a source of energy. Only within the last three decades has it become evident that complex carbohydrates form a highly diverse and complex class of biomolecules that are almost ubiquitous in any living organism and that mediate a large number of biological functions, ranging from purely structural roles to such complex processes as cell-cell interactions operative in the immune system or during embryonic development (for selected monographs and reviews see Rademacher et al. 1988; Kobata 1992; Varki 1993; Lis and Sharon 1993; Fukuda and Hindsgaul 1994; Montreuil et al. 1995). Moreover, inherited and acquired carbohydrate disorders have been discovered to play key roles in the etiology and progression of various types of disease, including metabolic disorders, immunological diseases, infections, and malignancy (selected references: Kornfeld 1986; von Figura and Hasilik 1986; Hakomori 1989; Etzioni et al. 1992; Furukawa and Kobata 1991; Muramatsu 1993; Ofek and Sharon 1990; Jaeken et al. 1993). Apart from contributing to the understanding of basic pathological mechanisms, studies on glycosylation changes in disease have led to the discovery of distinct carbohydrate structures as diagnostic markers of disease processes and to the development of novel diagnostic procedures and of new diagnostic and therapeutic agents (Young et al. 1991; Turner 1992; Muramatsu 1993; Mulligan et al. 1993; Parekh and Edge 1994).

Keywords

Sialic Acid Complex Carbohydrate Asialoglycoprotein Receptor Leukocyte Adhesion Deficiency Leukocyte Extravasation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • R. Tauber
  • S. Emig
  • B. Volz
  • C. Fieger
  • C. Bührer

There are no affiliations available

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