Immunological Aspects of the Toxic Oil Syndrome
The Toxic Oil Syndrome (TOS), which occurred in Spain in 1981, was caused by the ingestion of rapeseed oil denatured with 2% aniline, sold illegally as edible oil. The number of unaffected individuals exposed to the toxic oil is unknown, but more than 20,000 people suffered from the disease.
KeywordsJuvenile Rheumatoid Arthritis SCD23 Level Eosinophilia Myalgia Syndrome Reverse Transcriptase Polymerase Chain Reaction Technique Reactive Drug Metabolite
Unable to display preview. Download preview PDF.
- Aguilera B (1989) Lesiones vasculares en el Síndrome Tóxico por aceite de colza. Doctoral Thesis, Madrid Universidad Autónoma 26–41.Google Scholar
- Gleichmann H, Gleichman E (1984) GVHD a model for the Spanish Toxic Oil Syndrome. Lancet, i: 1174–1175.Google Scholar
- Kammüller M E, Bloksma N, Seinen W (1988) Chemically induced autoimmune reactions and Spanish toxic oil Syndrome. Focus on hydantoins and related compounds. J. Toxicol. 26:157–174.Google Scholar
- Kammüller ME., Bloksma N, Seinen W. (1989) Autoimmunity and toxicology. Immune dysregulation induced by drugs and chemicals. In: Kammüller M.E., Bloksma, N. and Seinen, W. (eds), Autoimmunity and toxicology. Immune dysregulation induced by drugs and chemicals. Elsevier, Amsterdam, pp 4–34.Google Scholar
- Lahoz C, Tricas L, Vela C, Lauzurica P, Gurbindo C, Garcia R (1983) Hyper IgE, eosinophilia and immunological hyperreactivity due to ingestion of adultered rapeseed oil (Toxic Oil Syndrome). Eur. J. Respir. Dis. 62: 415–418.Google Scholar
- Lahoz C, Rose NR, Robinson CJG (1992) Immunology. In: Nadal, J and Tarkowski, S (Eds), “Toxic Oil Syndrome: current Knowledge and future perspectives”. WHO Regional Publications, European series, no 42, pp. 143–152.Google Scholar
- Martínez Tello FJ, Téllez Y (1992) Pathology In: Nadal, J. and Tarkowski, S. (Eds), “Toxic Oil Syndrome: current Knowledge and future perspectives”. WHO Regional Publications, European series, no 42, pp. 39–65.Google Scholar
- Tricas, L. (1984) “Immunological hyperreactivity in the acute phase of TOS” Doctoral Thesis, University of Zaragoza.Google Scholar
- WHO (1991) “Toxic oil syndrome and eosinophilia-myalgia syndrome. Pursuing parallels in pathogenesis”. Report on a WHO meeting, Washington, DC., WHO Regional Office for Europe, Copenhagen, 22 pp.Google Scholar
- WHO (1992) “Toxic oil syndrome and eosinophilia-myalgia syndrome. Clinical aspects”. Report on a workshop. Stony Brook, New York. WHO Regional Office for Europe, Copenhagen, 19 pp.Google Scholar