Epidemiology of the Toxic Oil Syndrome

  • Rossanne M. Philen
  • Manuel Posada de la Paz
  • Robert H. Hill
  • Helen H. Schurz
  • Ignacio Abaitua Borda
  • Agustín Gómez de la Cámara
  • Edwin M. Kilbourne
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 19)

Abstract

During the early 1980’s importation of rapeseed oil into Spain for human consumption was illegal, except for the Canary Islands, although denatured rapeseed oil could be legally imported for industrial use. Denaturation of imported food oils with castor oil, methylene blue, or aniline was required by Spanish law and indicated that the oil was intended for industrial use due to undesirable properties of the denaturants.

Keywords

Methylene Blue Epidemic Curve World Health Organization Regional Direcci6n General Lite Bottle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bernert JT Jr, Kilbourne EM, Akins JR, et al. (1987) Compositional analysis of oil samples implicated in the Spanish toxic oil syndrome. J Food Sci 52:1562–9.CrossRefGoogle Scholar
  2. Cañas R, Kilbourne EM (1987) Oil ingestion and the toxic-oil syndrome: results of a survey of residents of the Orcasur neighbourhood in Madrid, Spain. Int J Epidemiol 16:3–6.PubMedCrossRefGoogle Scholar
  3. Casado Flores J, Casquero J, Colomar P, et al. (1982) Síndrome Tóxico por consumo de aceite adulterado: Una encuesta alimentaria esclarecedora. (Spanish) Pediátrika 2:17–20.Google Scholar
  4. Díaz de Rojas F, Castro García M, Abaitua Borda I, et al. (1987) The association of oil ingestion with toxic-oil syndrome in two convents. Am J Epidemiol 125:907–11.PubMedGoogle Scholar
  5. Direccion General de Planificación Sanitaria (1981) Propuesta de la Comisión Clínica. Síndrome Tóxico - Investigación. (Spanish) Ministerio de Trabajo, Sanidad y Seguridad Social; Madrid; May-August.Google Scholar
  6. Doll R (1987) The aetiology of the Spanish toxic syndrome: interpretation of the epidemiological evidence (including addendum June 1987). Copenhagen, WHO Regional Office for Europe (unpublished document SPA/CEH 502).Google Scholar
  7. Grandjean P, Tarkowski S, eds (1984) Toxic oil syndrome: mass food poisoning in Spain. In: Report of a WHO meeting: Madrid 21–25 March 1983. Copenhagen: World Health Organization Regional Office for Europe 22:3–16.Google Scholar
  8. Guitart R, Gelpi E (1991) Chemical composition of TOS related oils. In: World Health Organization, editor. Toxic oil syndrome: current knowledge and future perspectives. Copenhagen: World Health Organization Regional Publications 42:95–138.Google Scholar
  9. Hill RH, Schurz H, Posada M, et al. (1995) Possible Etiologic Agents for Toxic Oil Syndrome: Fatty Acid Esters of 3-(N-Phenylamino)-i,2-Propanediol. Arch Environmental Contam Toxicol 28:259–64.Google Scholar
  10. Jiang X, Khursigara G, Rubin RL (1994) Transformation of lupus inducing drugs to cytotoxic products by activated neutrophils. Science 266:810–3.PubMedCrossRefGoogle Scholar
  11. Kilbourne EM, Bernert JT Jr, Posada de la Paz M, et al. (1988) Chemical correlates of pathogenicity of oils related to the toxic-oil syndrome in Spain. Am J Epidemiol 127:1210–27.PubMedGoogle Scholar
  12. Lahoz C, Rose NR, Goter Robinson CJ (1991) Immunology. In World Health Organization, editor: Toxic oil syndrome: current knowledge and future perspectives. Copenhagen: World Health Organization Regional Publications, European Series 42:139–4.Google Scholar
  13. Philen RM, Posada M (1993)Toxic Oil Syndrome and Eosinophilia-Myalgia Syndrome: May 8–10, 1991, World Health Organization Meeting Report. Seminars in Arthritis and Rheumatism 23:104–24.CrossRefGoogle Scholar
  14. Posada de la Paz M, Philen RM, Abaitua Borda I, et al. (1991) Manufacturing processes at two French rapeseed oil companies: possible relationships to toxic oil syndrome in Spain. Food Chem Toxicol 29:797–803.PubMedCrossRefGoogle Scholar
  15. Posada M, Philen RM, Abaitua I, et al. (1994) A Further Study of Factors Associated with Pathogenicity of Oils Related to the Toxic Oil Syndrome Epidemic in Spain. Epidemiology 5:404–9.CrossRefGoogle Scholar
  16. Posada M, Philen RM, Abaitua I, et al. (1996) Toxic Oil Syndrome: A Study of Oil Composition by Container Type - Evidence for a Point Source Epidemic. Food and Chemical Toxicology 34:251–257.CrossRefGoogle Scholar
  17. Posada M, Castro M, Kilbourne EM, et al. (1987) Toxic-oil syndrome case reports associated with the ITH Oil Refinery in Sevilla. Food Chem Toxicol 25:87–90.PubMedCrossRefGoogle Scholar
  18. Posada de la Paz M, Abaitua Borda I, Kilbourne EM, et al. (1989) Late cases of toxic oil syndrome: evidence that the aetiological agent persisted in oil stored for up to one year. Food Chem Toxicol 27:517–21.PubMedCrossRefGoogle Scholar
  19. Rigau Pérez JG (1984) Summary of case-control studies and case or cluster investigations. In: Grandjean P, Tarkowski S, eds. Toxic oil syndrome: mass food poisoning in Spain. In: Report of a WHO meeting: Madrid 21–25 March 1983. Copenhagen: World Health Organization Regional Office for Europe 22:47–51.Google Scholar
  20. Rigau-Pérez JG, Pérez-Alvarez L, Dueñas-Castro S, et al. (1984) Epidemiologic investigation of an oil-associated pneumonic paralytic eosinophilic syndrome in Spain. Am J Epidemiol 119:250–60.PubMedGoogle Scholar
  21. Tabuenca JM (1984) Discovery of toxic oil as the cause of the epidemic. In: Grandjean P, Tarkowski S, eds. Toxic oil syndrome: mass food poisoning in Spain. Report of a WHO meeting: Madrid 21–25 March 1983. Copenhagen: World Health Organization Regional Office for Europe 22:39–46.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Rossanne M. Philen
    • 1
  • Manuel Posada de la Paz
    • 2
  • Robert H. Hill
    • 1
  • Helen H. Schurz
    • 1
  • Ignacio Abaitua Borda
    • 2
  • Agustín Gómez de la Cámara
    • 2
  • Edwin M. Kilbourne
    • 1
  1. 1.Centers for Disease Control and PreventionPublic Health Service, US Department of Health and Human ServicesAtlantaUSA
  2. 2.Instituto de Salud Carlos III, Subdirección General de SaludCentro de Investigación para el Síndrome del Aceite Tóxico, Ministerio de Sanidad y ConsumoMadridSpain

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