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Newborn Pig-to-Baboon Cardiac Xenotransplantation: A Model of Delayed Xenograft Rejection

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Xenotransplantation

Abstract

Cardiac transplantation is currently the best therapeutic option available to patients with end-stage heart disease. However, the supply of human donor hearts remains inadequate to meet the ever-increasing demand. Approximately 17 000 people per year under the age of 55 could benefit from cardiac allotrans-plantation in the United States alone. Unfortunately, no more than 2200 donor hearts per year are currently available [1]. As a result of this shortage, 30% of adult patients awaiting cardiac transplantation die before a donor is found [2]. The need for grafts is particularly desperate among newborn infants with congenital malformations, for whom the wait for an available organ results in death even more frequently than in adults.

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Authors
  1. S. Itescu
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  2. O. P. Minanov
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  3. R. E. Michler
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Editor information

Editors and Affiliations

  1. Immunologist (Surgery), Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 02129, Boston, Massachusetts, USA

    David K. C. Cooper M.A., M.D., Ph.D., M.S., F.R.C.S. (Associate Member, Scientific Staff) (Associate Member, Scientific Staff)

  2. Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

    David K. C. Cooper M.A., M.D., Ph.D., M.S., F.R.C.S. (Associate Member, Scientific Staff) (Associate Member, Scientific Staff)

  3. Department of Nephrology, Odense University Hospital, 5000, Odense, Denmark

    Ejvind Kemp M.D. (Professor and Head) (Professor and Head)

  4. Departments of Surgery, Pediatrics and Immunology, Duke University Medical Center, Durham, NC, 27710, USA

    Jeffrey L. Platt M.D. (Joseph W. and Dorothy W. Beard Professor) (Joseph W. and Dorothy W. Beard Professor)

  5. Department of Surgery, University of Cambridge, Cambridge, CB22QQ, UK

    David J. G. White M.A., Ph.D., M.R.C.Path (Immunologist and Lecturer, Director of Research and Development) (Immunologist and Lecturer, Director of Research and Development)

  6. Imutran Laboratories, Cambridge, UK

    David J. G. White M.A., Ph.D., M.R.C.Path (Immunologist and Lecturer, Director of Research and Development) (Immunologist and Lecturer, Director of Research and Development)

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© 1997 Springer-Verlag Berlin Heidelberg

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Itescu, S., Minanov, O.P., Michler, R.E. (1997). Newborn Pig-to-Baboon Cardiac Xenotransplantation: A Model of Delayed Xenograft Rejection. In: Cooper, D.K.C., Kemp, E., Platt, J.L., White, D.J.G. (eds) Xenotransplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60572-7_36

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  • DOI: https://doi.org/10.1007/978-3-642-60572-7_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64460-3

  • Online ISBN: 978-3-642-60572-7

  • eBook Packages: Springer Book Archive

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