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Minimally Invasive Follicular Thyroid Carcinoma: A Clinico-pathological Study

  • K. W. Schmid
  • T. Tötsch
  • D. Öfner
  • W. Böcker
  • D. Ladurner
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 91)

Abstract

According to the updated WHO classification of thyroid tumours (Hedinger et al. 1988), follicular thyroid carcinomas are divided into two prognostically relevant subgroups, minimally invasive and widely invasive follicular carcinoma. Unlike widely invasive follicular carcinoma, which can be clinically and surgically recognized as a cancer, minimally invasive follicular carcinoma can be diagnosed only by the pathologist.

Keywords

Vascular Invasion Follicular Carcinoma Follicular Thyroid Carcinoma Follicular Adenoma Local Tumour Recurrence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Czyz W, Joensuu H, Pylkkänen L, Klemi PJ (1994) p53 protein, PCNA staining, and DNA content in follicular neoplasms of the thyroid gland. J Pathol 174: 267–274PubMedCrossRefGoogle Scholar
  2. De Micco C, Ruf J, Chrestian M–A, Gros N, Henry J–F, Carayon P (1991) Immunohistochemical study of thyroid peroxidase in normal, hyperplastic, and neoplastic human thyroid tissues. Cancer 67: 3036–3041PubMedCrossRefGoogle Scholar
  3. Doniach I (1978) The thyroid gland. In: Symmers WSC (ed) Systemic pathology, vol 4, 2nd edn. Churchill Livingstone, Edinburgh, pp 1976–2037Google Scholar
  4. Evans HL (1984) Follicular neoplasms of the thyroid. Cancer 54: 535–540PubMedCrossRefGoogle Scholar
  5. Franssila KO, Ackerman LV, Brown CL, Hedinger CE (1985) Follicular carcinoma. Semin Diagn Pathol 2: 101–122PubMedGoogle Scholar
  6. Harach HR, Jasani B, Williams ED (1983) Factor VIII as a marker of endothelial cells in follicular carcinoma of the thyroid. J Clin Pathol 36: 1050–1054PubMedCrossRefGoogle Scholar
  7. Hazard JB, Kenyon R (1954) The atypical adenoma of the thyroid. Arch Pathol 58: 554–563Google Scholar
  8. Hedinger C, Williams ED, Sobin LH (1988) Histological typing of thyroid tumours 2nd edn. Springer, Berlin Heidelberg New York ( International classification of tumours, WHO, no 11 )Google Scholar
  9. Hofstädter F (1980) Frequency and morphology of malignant tumours of the thyroid before and after the introduction of iodine–prophylaxis. Virchows Arch [Pathol Anat] 385: 263–270CrossRefGoogle Scholar
  10. Hofstädter F, Unterkircher S (1980) Histologische Kriterien zur Prognose der Struma maligna. Pathologe 1:79–85PubMedGoogle Scholar
  11. Joensuu H, Klemi P, Eerola E (1986) DNA aneuploidy in follicular adenomas of the thyroid gland. Am J Pathol 124: 373–376PubMedGoogle Scholar
  12. Johannessen JV, Sobrinho–Simoes M (1982) Follicular carcinoma of the human thyroid gland. An ultrastructural study with emphasis on scanning electron microscopy. Diagn Histopathol 5: 113–127PubMedGoogle Scholar
  13. Johannessen JV, Sobrinho–Simoes M (1983) Well–differentiated thyroid tumors: problems in diagnosis and understanding. Pathol Annu 18: 255–285PubMedGoogle Scholar
  14. Johannessen JV, Sobrinho–Simoes M, Lindmo T, Tangen KO (1982) The diagnostic value of flow cytometric DNA measurements in selected disorders of the human thyroid. Am J Clin Pathol 77: 20–25PubMedGoogle Scholar
  15. Kahn NF, Perzin KH (1983) Follicular carcinoma of the thyroid: an evaluation of the histologic criteria usid for the diagnosis. Pathol Annu 18: 221–253PubMedGoogle Scholar
  16. Kober F, Wolf G, Depisch D, Galvan G, Keminger K, Ladurner D, Langsteger W, Ogris E, Pimpl W, Roka R, Schmalzer E, Schmid KW, Tuchmann A (1990) Schilddrüsenkarzinom. In: Steindorfer P (ed) Manual der chirurgischen Krebstherapie. Springer, Vienna New York, pp 35–48Google Scholar
  17. Ladurner D, Hofstädter F (1983) Zur Prognose des follikulären Schilddrüsenkarzinoms im Tiroler Strumaendemiegebiet. Langenbecks Arch Chir 360: 267–277PubMedCrossRefGoogle Scholar
  18. Lang W, Georgii A, Strauch G, Kienzle F (1980) The differentiation of atypical adenomas and encapsulated follicular carcinomas in the thyroid gland. Virchows Arch [Pathol Anat] 385: 125–141CrossRefGoogle Scholar
  19. Lang W, Choritz H, Hundeshagen H (1986) Risk factors in follicular thyroid carcinomas. A retrospective foliowup study covering a 14 year period with emphasis on morphological findings. Am J Surg Pathol 10:246–255PubMedCrossRefGoogle Scholar
  20. LiVolsi VA (1990) Follicular lesions of the thyroid. In: Surgical pathology of the thyroid. (Major problems in pathology, vol 22 ) Sauders, Philadelphia, pp173–212Google Scholar
  21. Mendelsohn G (1988) Pathology of thyroid disease. In: Mendelsohn G (ed) Diagnosis and pathology of endocrine diseases. Lippincott, Philadelphia, pp 37–137Google Scholar
  22. Mizukami Y, Nonomura A, Hashimoto T; Terahata S, Matsubara F, Michigishi T, Noguchi M (1988) Immunohistochemical demonstration of ras p21 oncogene product in normal, benign, and malignant thyroid tissues. Cancer 61: 873–880PubMedCrossRefGoogle Scholar
  23. Murray D (1991) The thyroid gland. In: Kovacs K, Asa SL (eds) Functional endocrine pathology, vol 1. Blackwell, Boston, pp 293–374Google Scholar
  24. Rüschoff J, Prasser C, Cortez T, Hohne HM, Hohenberger W, Hofstädter F (1993) Diagnostic value of AgNOR staining in follicular cell neoplasms of the thyroid: comparison of evaluation methods and nucleolar features. Am J Surg Pathol 17:1281–1288PubMedCrossRefGoogle Scholar
  25. Schmid KW (1993) Immunohistochemistry and in situ hybridisation in thyroid cancer. Exp Clin Endocrinol 101: 17–22CrossRefGoogle Scholar
  26. Schmid KW, Tötsch M, Hittmair A, Feichtinger H, Ladurner D Hofstädter F (1989) Frequency of medullary thyroid carcinoma in an endemic area. Mod Pathol 2: 90–93PubMedGoogle Scholar
  27. Schmid KW, Greeff M, Hittmair A, Tötsch M, Öfner D D ckhorn–Dworniczak B, Böcker W, Jasani B (1994) Metallothionein expression in normal hyperplastic and neoplastic thyroid follicular and parafollicular cells using monoclo al ant netallothioneln antibody E9. Endocr Pathol 5: 114–122CrossRefGoogle Scholar
  28. Schröder S (1988) Pathologie und Klinik maligner Schilladrüsentumoren. Fischer, StuttgartGoogle Scholar
  29. Schröder S, Pfannschmidt N, Dralle H, Arps H, Böcker W (1984) The encapsulated follicular carcinoma of the thyroid. A clinicopathological study of 35 cases. Virchows Arch [A] 402: 259–273CrossRefGoogle Scholar
  30. Williams ED (1980) Pathology and natural history. In: Duncan W (ed) Thyroid cancer. Springer, Berlin Heidelbeg New York, pp 47–55Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • K. W. Schmid
  • T. Tötsch
  • D. Öfner
  • W. Böcker
  • D. Ladurner

There are no affiliations available

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