Sialodacryoadenitis Virus Infection, Rat

  • Robert O. Jacoby
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Lesions develop during the first week after infection and occur primarily in the submandibular and parotid salivary glands, which are located on the anteroventral and anterolateral aspects of the neck, respectively (Fig. 215). Affected glands are unilaterally or bilaterally enlarged and pale yellow to white in contrast to their normal tan color (Fig. 216). Periglandular connective tissue is often edematous and, together with glandular enlargement, may cause clinically detectable cervical swelling. The cervical lymph nodes may also be enlarged and edematous. They are frequently congested, especially early in infection, and occasionally flecked with red spots.


Rat coronavirus infection 


  1. Ashe WK (1969) Properties of the rat submaxillary gland virus hemagglutinin and antihemagglutinin and their incidence in apparently healthy gnotobiotic and conventional rats. J Gen Virol 4:1–7PubMedCrossRefGoogle Scholar
  2. Barthold SW (1985) Research complications and state of knowledge of rodent Coronavirus. In: Hamm TA (ed) Complications of viral and mycoplasmal infections in rodents to toxicology research and testing. Hemisphere, Washington DCGoogle Scholar
  3. Bhatt PN, Jacoby RO (1977) Experimental infection of adult axenic rats with Parker’s rat Coronavirus. Arch Virol 54:345–352PubMedCrossRefGoogle Scholar
  4. Bhatt PN, Jacoby RO (1985) Epizootiological observations of natural and experimental infection with sialodacryoadenitis virus in rats. Lab Anim Sci 35:129–134PubMedGoogle Scholar
  5. Bhatt PN, Percy DH, Jonas AM (1972) Characterization of the virus of sialodacryoadenitis of rats: a member of the Coronavirus group. J Infect Dis 126:123–130PubMedCrossRefGoogle Scholar
  6. Bhatt PN, Jacoby RO, Jonas AM (1977) Respiratory infection in mice with sialodacryoadenitis virus, a Coronavirus of rats. Infect Immun 18:823–827PubMedGoogle Scholar
  7. Gaertner DJ, Smith AL, Paturzo FX, Jacoby RO (1991) Susceptibility of rodent cell lines to rat coronaviruses and differential enhancement by trypsin or DEAE-dextran. Arch Virol 118:57–66PubMedCrossRefGoogle Scholar
  8. Greene EC (1959) Anatomy of the rat. Hafner, New York, p 93 (Transactions of American Philosophical Society, vol 27)Google Scholar
  9. Jacoby RO (1986) Rat Coronavirus. In: Bhatt PN, Jacoby RO, Morse HC, New AE (eds) Viral and mycoplasmal infections of laboratory rodents: effects on biomedical research. Academic, Orlando, pp 625–638Google Scholar
  10. Jacoby RO, Bhatt PN, Jonas AM (1975) Pathogenesis of sialodacryoadenitis in gnotobiotic rats. Vet Pathol 12:196–209PubMedGoogle Scholar
  11. Jacoby RO, Bhatt PN, Jonas AM (1979) Viral disease. In: Baker H, Lindsey JR, Weisbroth SH (eds) The laboratory rat, vol 1: biology and diseases. Academic, New York, chap 11Google Scholar
  12. Jonas AM, Craft J, Black L, Bhatt PN, Hilding D (1969) Sialodacryoadenitis in the rat. A light and electron microscopic study. Arch Pathol 88:613–622PubMedGoogle Scholar
  13. Lai YL, Jacoby RO, Bhatt PN, Jonas AM (1976) Keratoconjunctivitis associated with sialodacryoadenitis in rats. Invest Ophthalmol 15:538–541PubMedGoogle Scholar
  14. Lyon HW, Christian JJ, Miller CW (1959) Cytomegalic inclusion disease of lacrimal glands in male laboratory rats. Proc Soc Exp Biol Med 101:164–166PubMedGoogle Scholar
  15. Parker JC, Cross SS, Rowe WP (1970) Rat coronavirus (RCV): a prevalent, naturally occurring pneumotropic virus of rats. Arch Gesamte Virusforsch 31:293–302PubMedCrossRefGoogle Scholar
  16. Percy DH, Hayes MA, Kocal TE, Wojcinski ZW (1988) Depletion of salivary gland epidermal growth factor by sialodacryoadenitis virus infection in the Wistar rat. Vet Pathol 25:183–192PubMedCrossRefGoogle Scholar
  17. Percy DH, Bond S, Maclnnes J (1989) Replication of sialodacryoadenitis virus in mouse L-2 cells. Arch Virol 104:323–333PubMedCrossRefGoogle Scholar
  18. Percy DH, Bond SJ, Paturzo FX, Bhatt PN (1990) Duration of protection from reinfection following exposure to sialodacryoadenitis virus in Wistar rats. Lab Anim Sci 40:144–149PubMedGoogle Scholar
  19. Peters RL, Collins MJ Jr (1981) Use of mouse hepatitis virus antigen in an enzyme-linked immunosorbent assay for rat coronaviruses. Lab Anim Sci 31:472–475PubMedGoogle Scholar
  20. Smith AL (1983) An immunofluorescence test for detection of serum antibody to rodent coronaviruses. Lab Anim Sci 33:157–160PubMedGoogle Scholar
  21. Taguchi F, Yamada A, Fujiwara K (1979) Asymptomatic infection of mouse hepatitis virus in the rat. Arch Virol 59:275–279PubMedCrossRefGoogle Scholar
  22. Utsumi K, Ishikawa T, Maeda T, Shimizu S, Tatsumi H, Fujiwara K (1980) Infectious sialodacryoadenitis and rat breeding. Lab Anim 14:303–307PubMedCrossRefGoogle Scholar
  23. Vickers RA, Gorlin RJ (1977) Face, lips, teeth, mouth, jaws, salivary glands and neck. In: Anderson WAD, Kissane JM (eds) Pathology, 7th edn, vol 2. Mosby, St Louis, chap 29Google Scholar
  24. Weir EC, Jacoby RO, Paturzo FX, Johnson EA, Ardito RB (1990a) Persistence of sialodacryoadenitis virus in athymic rats. Lab Anim Sci 40:138–143PubMedGoogle Scholar
  25. Weir EC, Jacoby RO, Paturzo, FX, Johnson EA (1990b) Infection of SD AV-immune rats with SD AV and rat coronavirus. Lab Anim Sci 40:363–366PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Robert O. Jacoby

There are no affiliations available

Personalised recommendations