Mechanisms for Posttranscriptional Regulation by Iron-Responsive Elements and Iron Regulatory Proteins

  • M. Muckenthaler
  • M. W. Hentze
Chapter
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 18)

Abstract

Iron deficiency is a wide-spread nutritional problem amongst the world’s population. Often the symptoms like pallor, fatigue, and anemia yield to treatment with iron, but irreversible harmful effects of iron deficiency in the development of children have also been observed. On the other extreme, primary or secondary iron overload can lead to hemochromatosis or hemosiderosis, which are characterized by iron deposits and multiorgan pathology including liver cirrhosis, cardiac dysfunction, and arthritis.

Keywords

Transferrin Receptor Translational Repression Posttranscriptional Regulation Iron Regulatory Protein Aconitase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • M. Muckenthaler
    • 1
  • M. W. Hentze
    • 1
  1. 1.Gene Expression ProgrammeEuropean Molecular Biology LaboratoryHeidelbergGermany

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