The Role of Cytokines in the Pathogenesis of Myocarditis

  • P. Liu
Conference paper

Abstract

Cytokines are multipurpose low molecular weight “pleotropic” intercellular signaling peptides that are the major mediators of inflammation, cellular growth, cellular transformation, nuclear activation, matrix repair, gene regulation and cell death. They have been best identified with the immune system, to bring about the coordinated response following injury in all tissues (Lange and Schreiner 1994). At low doses, cytokine fine tune the body system for maintenance function. The cytokines regulate host cell function through autocrine (self-regulation) or paracrine (regulation of neighbouring cells) pathways. In cases of severe stimulation, high doses of cytokines are released into the blood stream to produce a potentially endocrine effect. This high level of cytokines may be toxic to target cells. The teleological purpose of this action is to eliminate potentially sources of harm for the organism (such as infected cells), but it ultimately can cause the destruction of the host cell.

Keywords

Dilate Cardiomyopathy Viral Myocarditis Viral Inoculation Acute Myocarditis Growth Factor Family 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • P. Liu
    • 1
  1. 1.General DivisionGW1-508, The Toronto HospitalTorontoCanada

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