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The Role of Superantigenicity of Silicate in the Pathogenesis of Autoimmune Diseases in Patients with Silicosis or Asbestosis

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New Trends in Allergy IV

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Abstract

Silica or related substances such as silicone or asbestos have adjuvant effects. We obtained evidence that V ß repertoire V ß 5.3 was predominantly expressed on fractionated T cells with a high Ca2+ level that had been stimulated by chrysotile asbestos in vitro. The intracellular Ca2+ level in human peripheral blood mononuclear cells (PBMC) increased after incubation with silica or chrysotile. Interleukin (IL)-2 release from PMBC also rose significantly after chrysotile stimulation, but no change was observed when major histocompatibility complex (MHC) class II DP/DR positive cells were depleted. Therefore, it seems that the biological effect of silicate is as a superantigen that might play a role in the pathogenesis of autoimmune diseases.

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References

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Authors
  1. A. Ueki
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  2. K. Kinugawa
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  3. Y. Watanabe
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  4. M. Yamaguchi
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  5. M. Nakashima
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  6. J. Nakamura
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  7. T. Kishimoto
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  8. H. Sakaguchi
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  9. Y. Miyahara
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Editor information

Editors and Affiliations

  1. Klinik and Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Str. 29, 80802, München, Germany

    Johannes Ring

  2. Abt. Experimentelle Dermatologie und Allergologie, Universitäts-Krankenhaus Eppendorf, Martinistraße 53, 20246, Hamburg, Germany

    Heidrun Behrendt

  3. Hautklinik/Allergieabteilung, Universitäts-Krankenhaus Eppendorf, Martinistraße 53, 20246, Hamburg, Germany

    Dieter Vieluf

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© 1997 Springer-Verlag Berlin Heidelberg

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Ueki, A. et al. (1997). The Role of Superantigenicity of Silicate in the Pathogenesis of Autoimmune Diseases in Patients with Silicosis or Asbestosis. In: Ring, J., Behrendt, H., Vieluf, D. (eds) New Trends in Allergy IV. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60419-5_45

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  • DOI: https://doi.org/10.1007/978-3-642-60419-5_45

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64398-9

  • Online ISBN: 978-3-642-60419-5

  • eBook Packages: Springer Book Archive

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