Involvement of the SHP-1 Tyrosine Phosphatase in Regulating B Lymphocyte Antigen Receptor Signaling, Proliferation and Transformation

  • K. A. Siminovitch
  • A.-M Lamhonwah
  • A.-K Somani
  • R. Cardiff
  • G. B. Mills
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 246)

Abstract

The SHP-1 tyrosine phosphatase is a cytosolic protein tyrosine phosphatase (PTP) distinguished by its predominant expression in haemopoietic cells and the presence of two tandemly-located SH2 domains [1,2]. A pivotal role for this PTP in regulating lymphoid cell proliferation and growth was initially revealed by the discovery that loss-of-function mutations in the gene encoding SHP-1 are responsible for the severe systemic autoimmunity and inflammation observed in mice homozygous for the motheaten (me) or viable motheaten (me v ) mutations [3, 4]. These animals manifest multiple myeloid/macrophage and lymphoid cell defects, the latter of which include overexpansion of the normally minor B-l cell population in the periphery and consequent hypergammaglobulinia, autoantibody production and immune complex deposition [5, 6].

Keywords

Tyrosine Phosphatase Protein Tyrosine Phosphatase Childhood Acute Lymphoblastic Leukemia Cell Antigen Receptor Antigen Receptor Signaling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • K. A. Siminovitch
    • 1
  • A.-M Lamhonwah
    • 1
  • A.-K Somani
    • 1
  • R. Cardiff
    • 2
  • G. B. Mills
    • 3
  1. 1.Departments of Medicine, Immunology and Molecular & Medical GeneticsUniversity of Toronto and the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Room 656ATorontoCanada
  2. 2.Department of Pathology, School of MedicineUniversity of California at DavisDavisUSA
  3. 3.Molecular Oncology, Division of MedicineThe University of Texas, MD Anderson Cancer CenterHoustonUSA

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