Human Macrophage-Derived Chemokine (MDC) is Strongly Expressed Following Activation of both Normal and Malignant Precursor and Mature B Cells

  • P. Ghia
  • C. Schaniel
  • A.G Rolink
  • L. M. Nadler
  • A. A. Cardoso
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 246)

Abstract

Chemokines are a rapidly expanding group of secreted molecules that selectively control the migration and homing of leukocytes to different sites of inflammation and immune responses [1, 2]. They are believed to perform key functions in secondary lymphoid tissues, where they attract antigen-bearing dendritic cells (DC) [3, 4] and antigen-specific T and B cells, promoting interactions among them and guiding them to appropriate sites [2, 5].

Keywords

Follicular Lymphoma Secondary Lymphoid Tissue Soluble CD40 Ligand Plastic Tissue Culture Dish Burkitt Lymphoma Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    . Rollins BJ (1997) Chemokines. Blood 90: 909 – 928Google Scholar
  2. 2.
    Baggiolini M (1998) Chemokines and leukocyte traffic. Nature 392: 565 – 568PubMedCrossRefGoogle Scholar
  3. 3.
    Dieu MC, Vanbervliet B, Vicari A, Bridon JM, Oldham E, Ait-Yahia S, Briere F, Zlotnik A, Lebecque S, Caux C (1998) Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med 188: 373 – 386PubMedCrossRefGoogle Scholar
  4. 4.
    . Sozzani S, Allavena P, D’Amico G, Luini W, Bianchi G, Kataura M, Imai T, Yoshie O, Bonecchi R, Mantovani A (1998) Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties. J Immunol 161: 1083 – 1086PubMedGoogle Scholar
  5. 5.
    . Ward SG, Bacon K, Westwick J (1998) Chemokines and T lymphocytes: more than an attraction. Immunity 9: 1 – 11PubMedCrossRefGoogle Scholar
  6. 6.
    Goodnow CC, Cyster JG (1997) Lymphocyte homing: the scent of a follicle. Curr Biol 7: R219 – 222PubMedCrossRefGoogle Scholar
  7. 7.
    Hedrick JA, Zlotnik A (1997) Identification and characterization of a novel beta chemokine containing six conserved cysteines. J Immunol 159: 1589 – 1593PubMedGoogle Scholar
  8. 8.
    Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C, Broxmeyer HE (1997) Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension. J Immunol 159: 2554 – 2558PubMedGoogle Scholar
  9. 9.
    Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpaa M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997) Molecular cloning of a novel human CC chemokine secondary lymphoid- tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9pl3. J Biol Chem 272: 19518 – 19524PubMedCrossRefGoogle Scholar
  10. 10.
    Tanabe S, Lu Z, Luo Y, Quackenbush EJ, Berman MA, Collins-Racie LA, Mi S, Reilly C, Lo D, Jacobs KA, Dorf ME (1997) Identification of a new mouse beta-chemokine, thymus- derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells. J Immunol 159: 5671 – 5679PubMedGoogle Scholar
  11. 11.
    Gunn MD, Tangemann K, Tam C, Cyster JG, Rosen SD, Williams LT (1998) A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc Natl Acad Sci U S A 95: 258 – 263PubMedCrossRefGoogle Scholar
  12. 12.
    Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A (1997) Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP- 3alpha and MIP-3beta. J Immunol 158: 1033 – 1036PubMedGoogle Scholar
  13. 13.
    . Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997) Molecular cloning of a novel human CC chemokine EBI1- ligand chemokine that is a specific functional ligand for EBI1, CCR7. J Biol Chem 272: 13803 – 13809PubMedCrossRefGoogle Scholar
  14. 14.
    Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E (1993) Epstein-Barr virus- induced genes: first lymphocyte-specific G protein- coupled peptide receptors. J Virol 67: 2209 – 2220PubMedGoogle Scholar
  15. 15.
    Ngo VN, Tang HL, Cyster JG (1998) Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J Exp Med 188: 181 – 191PubMedCrossRefGoogle Scholar
  16. 16.
    . Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (1998) A B-cell- homing chemokine made in lymphoid follicles activates Burkitt’s lymphoma receptor-1. Nature 391: 799 – 803PubMedCrossRefGoogle Scholar
  17. 17.
    Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (1998) B cell- attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 187: 655 – 660PubMedCrossRefGoogle Scholar
  18. 18.
    Forster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M (1996) A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87: 1037 – 1047PubMedCrossRefGoogle Scholar
  19. 19.
    Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, Kishimoto T (1996) Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382: 635 – 638PubMedCrossRefGoogle Scholar
  20. 20.
    D’Apuzzo M, Rolink A, Loetscher M, Hoxie JA, Clark-Lewis I, Melchers F, Baggiolini M, Moser B (1997) The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4. Eur J Immunol 27: 1788 – 1793PubMedCrossRefGoogle Scholar
  21. 21.
    Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, Springer TA (1996) A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) [see comments]. J Exp Med 184: 1101 – 1109PubMedCrossRefGoogle Scholar
  22. 22.
    Sharma V, Walper D, Deckert R (1997) Modulation of macrophage inflammatory protein- 1 alpha and its receptors in human B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt’s lymphoma. Biochem Biophys Res Commun 235: 576 - 581PubMedCrossRefGoogle Scholar
  23. 23.
    Schaniel C, Pardali E, Sallusto F, Speletas M, Ruedl C, Shimizu T, Seidl T, Andersson J, Melchers F, Rolink AG, Sideras P (1998) Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells. J Exp Med 188: 451 – 463PubMedCrossRefGoogle Scholar
  24. Chang M, McNinch J, Elias Cr, Manthey CL, Grosshans D, Meng T, Boone T, Andrew DPGoogle Scholar
  25. (1997) Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes. J Biol Chem 272: 25229–25237Google Scholar
  26. 25.
    Godiska R, Chantry D, Raport CJ, Sozzani S, Allavena P, Leviten D, Mantovani A, Gray PW (1997) Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. J Exp Med 185: 1595 – 1604PubMedCrossRefGoogle Scholar
  27. 26.
    Gribben JG, Freedman AS, Neuberg D, Roy DC, Blake KW, Woo SD, Grossbard ML, Rabinowe SN, Coral F, Freeman GJ, et al. (1991) Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B-cell lymphoma [see comments]. New England Journal of Medicine 325: 1525 – 1533PubMedCrossRefGoogle Scholar
  28. 27.
    Ghia P, Boussiotis VA, Schultze JL, Cardoso AA, Dorfman DM, Gribben JG, Freedman AS, Nadler LM (1998) Unbalanced expression of bcl-2 family proteins in follicular lymphoma: contribution of CD40 signaling in promoting survival. Blood 91: 244 – 251PubMedGoogle Scholar
  29. 28.
    Liu YJ, Barthelemy C, de Bouteiller O, Arpin C, Durand I, Banchereau J (1995) Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2. Immunity 2: 239 – 248PubMedCrossRefGoogle Scholar
  30. 29.
    Ghia P, ten Boekel E, Sanz E, de la Hera A, Rolink A, Melchers F (1996) Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain gene loci. J Exp Med 184: 2217 – 2229PubMedCrossRefGoogle Scholar
  31. 30.
    Lane P, Brocker T, Hubele S, Padovan E, Lanzavecchia A, McConnell F (1993) Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell- dependent activation. J Exp Med 177: 1209 – 1213PubMedCrossRefGoogle Scholar
  32. 31.
    Petrasch S, Kosco M, Perez-Alvarez C, Schmitz J, Brittinger G (1992) Proliferation of non- Hodgkin-lymphoma lymphocytes in vitro is dependent upon follicular dendritic cell interactions. British Journal of Haematology 80: 21 – 26PubMedCrossRefGoogle Scholar
  33. 32.
    Lindhout E, Mevissen ML, Kwekkeboom J, Tager JM, de Groot C (1993) Direct evidence that human follicular dendritic cells (FDC) rescue germinal centre B cells from death by apoptosis. Clinical & Experimental Immunology 91: 330 – 336CrossRefGoogle Scholar
  34. 33.
    Carbone A, Gloghini A, Gruss HJ, Pinto A (1995) CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin’s disease. American Journal of Pathology 147: 912 – 922PubMedGoogle Scholar
  35. 34.
    Ghia P, ten Boekel E, Rolink AG, Melchers F (1998) B-cell development: a comparison between mouse and man [In Process Citation]. Immunol Today 19: 480 – 485PubMedCrossRefGoogle Scholar
  36. Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PWGoogle Scholar
  37. (1998) Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J Biol Chem 273: 1764–1768Google Scholar
  38. 36.
    Cardoso AA, Seamon MJ, Afonso HM, Ghia P, Boussiotis VA, Freeman GJ, Gribben JG, Sallan SE, Nadler LM (1997) Ex vivo generation of human anti-pre-B leukemia-specific autologous cytolytic T cells. Blood 90: 549 – 561PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • P. Ghia
    • 1
    • 2
  • C. Schaniel
    • 3
  • A.G Rolink
    • 3
  • L. M. Nadler
    • 1
  • A. A. Cardoso
    • 1
  1. 1.Dana-Farber Cancer Institute, Harvard Medical SchoolBostonUSA
  2. 2.Istituto per la Ricerca e la Cura del CancroCandioloItaly
  3. 3.Basel Institute for ImmunologyBaselSwitzerland

Personalised recommendations