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Cosmetics pp 226-240 | Cite as

Fragrances Between Allergic, Hypoallergic,and Irritant: In Vitro Studies

  • S. Sieben
  • B. Blömeke
  • H. F. Merk
Chapter

Abstract

Fragrances are ubiquitously used to refine cosmetic, hygiene and household products such as soaps, shampoos, lotions, facial and toilet tissues, household cleansers and detergents but also medicaments, food, plastics, paper, or paints (Tables 1 and 2) [25,27, 34, 37, 49, 53, 74, 83]. Until the last century, natural extracts from plants and animal secretions have been the only source of raw materials for fragrances. Today, approximately 3000 synthetic and 300-400 natural fragrances are used in fragrance industry [6]. Natural fragrances are commonly extracted from essential plant oils and animal secretions (isolates), tree bark (balsams), or are obtained by solvent extraction from plant materials (concretes, absolutes [33]). Well known examples of isolates are eugenol from cloverleaf, citral from lemmon grass and menthol from peppermint oil [65]. In general, many fragrances are viscous, oily substances. However, they are very heterogeneous regarding their chemical structures. Fragrances can be classified for example as terpenes, aromatics, aliphatics, as well as alicyclics and heterocyclics [38,65].

Keywords

Contact Dermatitis Allergic Contact Dermatitis Lymphocyte Transformation Test Linalyl Acetate Pool Human Serum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Aiba S, Katz SI (1990) Phenotypic and functional characteristics of in-vivo activated Langerhans cells. J Immunol 145:2791–2796PubMedGoogle Scholar
  2. 2.
    Aldridge RD, Milton JI, et al. (1985) Leukocyte procoagulant activity as an in-vitro index of nickel contact hypersensitivity. Int Arch Allergy Appl Immunol 76:350–353PubMedCrossRefGoogle Scholar
  3. 3.
    Baron JM, Merk HF, et al. (1998) Cytochrome P450 1B1 is a major P450 isoenzyme in human blood monocytes and macrophage subsets. Biochem Pharmacol (in press)Google Scholar
  4. 4.
    Basketter DA (1992) Skin sensitisation to cinnamic alcohol: the role of skin metabolism. Arch Derm Venerol 72:264–265Google Scholar
  5. 5.
    Basketter DA, Pendlington RU, et al. (1996) The role of P450 1 A in the activation of prophaptens in skin sensitization. J Invest Dermatol 106:915Google Scholar
  6. 6.
    Bauer, K, Garbe, D, et al. (1990) Common fragrance and flavor materials: preparation, properties and uses. VCH Verlagsgesellschaft, Weinheim, GermanyGoogle Scholar
  7. 7.
    Bierer BE, Burakoff SJ (1988) T cell adhesion molecules. FASEB J 2:2584–2590PubMedGoogle Scholar
  8. 8.
    Bloom BR, Bennett B (1966) Mechanism of a reaction in vitro associated with delayed hypersensitivity. Science 153:80–82PubMedCrossRefGoogle Scholar
  9. 9.
    Bottomly K (1988) A functional dichotomy in CD4+ T lymphocytes. Immunology Today 9(9) 268–274PubMedCrossRefGoogle Scholar
  10. 10.
    Breitmeyer IB (1987) Lymphocyte activation. How T cells communicate. Nature 329:760–761Google Scholar
  11. 11.
    Brüning T (1994) A nonradioactive lymphocyte proliferation assay for diagnostics of cellular immune defects in a clinical laboratory. Klin Lab 40:917–927Google Scholar
  12. 12.
    Byers VS, Epstein WL, et al. (1979) In vitro studies of poison oak immunity. I. In vitro reaction of human lymphocytes to urushiol. J Clin Invest 64:1437–1448Google Scholar
  13. 13.
    Caron GA, Sarkany I, et al. (1965) Radioactive method for the measurement of lymphocyte transformation in vitro. Lancet 11:1266–1268CrossRefGoogle Scholar
  14. 14.
    Cartwright T, Shah GP (1994) Culture media. In: Davis JM (ed) Basic cell culture. A practical approach. Oxford University Press, New York, pp.57–91Google Scholar
  15. 15.
    Caux C, Massacrier C, et al. (1995) Human dendritic Langerhans cells generated in vitro from CD34+ progenitors can prime naive CD4+ T cells and process soluble antigen. J Immunol 155:5427–5435PubMedGoogle Scholar
  16. 16.
    Cederbrant K, Hultman P, et al. (1997) In vitro lymphocyte proliferation as compared to patch test using gold, palladium and nickel. Int Arch Allergy Immunol 112(3)212–217PubMedCrossRefGoogle Scholar
  17. 17.
    Cooke MA (1991) IFRA and the dermatologist. Contact Dermatitis 25:209–210PubMedCrossRefGoogle Scholar
  18. 18.
    Cooke MA, Cadby PA, et al. (1989a) Databases in the perfumery industry. Semin Dermatol 8:85–87PubMedGoogle Scholar
  19. 19.
    Cooke MA, Cadby PA, et al. (1989b) Data generation from perfume ingredient safety evaluation. In: Frosch PJ (ed) Current topics in contact dermatitis, Springer-Verlag, Heidelberg, 122–126Google Scholar
  20. 20.
    Coombs RRA, Gell PGH (1975) Classification of allergic reactions for clinical hypersensitivity and desease. In: Gell PGH, Coombs RRA, Lachman R (eds) Clinical aspects of immunology. Oxford Blackwell Scientific, London, pp. 761–781Google Scholar
  21. 21.
    Cooper HL, Rubin AD (1965) RNA metabolism in lymphocytes stimulated by phytohemagglutinin: initial responses to phytohemagglutinin. Blood 25:1014–1027PubMedGoogle Scholar
  22. 22.
    Croft M, Swain SL (1995) Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines. J Immunol 154:4269–4282PubMedGoogle Scholar
  23. 23.
    De Groot AC, Liem DH (1983) Contact urticaria to rouge. Contact Dermatitis 9:322PubMedCrossRefGoogle Scholar
  24. 24.
    De Groot AC, Frosch PJ (1997) Adverse reactions to fragrances. Contact Dermatitis 36:57–86PubMedCrossRefGoogle Scholar
  25. 25.
    De Groot AC, Baar AIM, et al. (1991) Contact allergy to moist toilet paper. Contact Dermatitis 24:135–136PubMedCrossRefGoogle Scholar
  26. 26.
    De Groot AC, Weyland JW, et al. (1994) Unwanted effects of cosmetics and drugs used in dermatology. Amsterdam, ElsevierGoogle Scholar
  27. 27.
    Dooms-Goossens A, Dubelloy R, et al. (1990) Contact and systemic contact-type dermatitis to spices. In: Adams RM, Nethercott JR (eds) Dermatologie Clinics. Contact Dermatitis. WB Saunders Company, Philadelphia, pp. 89–93Google Scholar
  28. 28.
    Egner W, Hart DNJ (1995) The phenotype of freshly isolated and cultured human bone marrow allostimulatory cells: possible heterogeneity in bone marrow dendritic cell populations. Immunology 85:611PubMedGoogle Scholar
  29. 29.
    Enders F, Przybilla B, et al. (1991) Patch testing with fragrance-mix and its constituents: discrepancies are largely due to the presence or absence of sorbitan sesquioleate. Contact Dermatitis 24:238PubMedCrossRefGoogle Scholar
  30. 30.
    Enk AH, Katz SI (1992) Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci USA 89:1398–1402PubMedCrossRefGoogle Scholar
  31. 31.
    Everness KM, Gawkrodger DJ, et al. (1990) The discrimination between nickel-sensitive and nonnickel-sensitive subjects by an in vitro lymphocyte transformation test. Br J Dermatol 122:293–298PubMedCrossRefGoogle Scholar
  32. 32.
    Fenn RS (1989) Aroma chemical usage trends in modern perfumery. Perfumer and Flavorists 14:3–10Google Scholar
  33. 33.
    Fischer T (1995) Perfumed products. In: GuIn ID (ed) Practical contact dermatitis. McGraw-Hill, New York, pp. 355–371Google Scholar
  34. 34.
    Fisher AA (1973) Allergic reactions to feminine hygiene sprays. Arch Dermatol 108:801–803PubMedCrossRefGoogle Scholar
  35. 35.
    Giovinazzo VJ, Harber LC, et al. (1981) Photoallergic contact dermatitis to musk ambrette. Histopathological features of photobiologic reactions observed in a persistent light reactor. Arch Dermatol 117:344–348Google Scholar
  36. 36.
    Goncalo S, Gil I, et al. (1991) Pigmented photoallergic contact dermatitis from musk ambrette. Contact Dermatitis 24:229–230PubMedCrossRefGoogle Scholar
  37. 37.
    Guin ID (1981) Contact dermatitis to perfume in paper products. J Am Acad Dermatol 4:733–734PubMedCrossRefGoogle Scholar
  38. 38.
    Hausen B (1996) Lexikon der Kontaktallergene. Ecomed Verlag, Landsberg, GermanyGoogle Scholar
  39. 39.
    Hayakawa R, Matsunaga K, et al. (1987) Airborne pigmented contact dermatitis due to musk ambrette in incense. Contact Dermatitis 16:96–98PubMedCrossRefGoogle Scholar
  40. 40.
    Hayakawa R, Hirose O, et al. (1991)Pigmented contact dermatitis due to musk moskene.J Dermatol 18:420–421Google Scholar
  41. 41.
    Hirschberg H, Braathen LR, et al. (1982) Antigen presentation by vascular endothelial cells and epidermal Langerhans cells: the role of HLA-DR. Immunol Rev 65:57–77CrossRefGoogle Scholar
  42. 42.
    Hoffman KM, Ho DG, et al. (1997) Evaluation of the usefulness of lymphocyte proliferation assays in the diagnosis of allergy to cow’s milk. J Allergy Clin Immunol 99(3)360–366PubMedCrossRefGoogle Scholar
  43. 43.
    lenkins MK, Johnson JG (1993) Molecules involved in T-cell costimulation. Curr Opin Immunol 5:361–367CrossRefGoogle Scholar
  44. 44.
    Jonuleit H, Müller G, et al. (1996) IL-1-β upregulation in dendritic cells by contact sensitizers: generation of an in vitro test system for contact allergens (Abstr.). Arch Dermatol Res 288:279CrossRefGoogle Scholar
  45. 45.
    Jonuleit H, Kiihn U, et al. (1997) Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 24: (in press)Google Scholar
  46. 46.
    Jordan WP, Dvorak J (1976) Leukocyte migration inhibition assay (LIF) in nickel contact dermatitis. Arch Dermatol 112:1741–1744PubMedCrossRefGoogle Scholar
  47. 47.
    Kalish RS, Morimoto C (1989) Quantitation and cloning of human urushiol specific peripheral blood T-cells: isolation of urushiol triggered suppressor T-cells. J Invest Dermatol 92:46–52PubMedCrossRefGoogle Scholar
  48. 48.
    Kapsenberg ML, Res P, et al. (1987) Nickel-specific T lymphocyte clones derived from allergic nickel-contact dermatitis lesions in man: heterogeneity based on requirement of dendritic antigenpresenting cell subsets. Eur J Immunol 17:861–865PubMedCrossRefGoogle Scholar
  49. 49.
    Keith L, Erich W, et al. (1969) Toilet paper dermatitis. JAMA 209:269PubMedCrossRefGoogle Scholar
  50. 50.
    Kelso A (1995) Thl and Th2 subsets: paradigms lost? Immunology Today 16(8)374–379PubMedCrossRefGoogle Scholar
  51. 51.
    Kimber I, Quirke S, et al. (1991) Lymphocyte transformation and thiuram sensitization. Contact Dermatitis 24:164–171PubMedCrossRefGoogle Scholar
  52. 52.
    Landsteiner K, Jacobs JL (1936) Studies on the sensitization of animals with simple chemicals. J Exp Med 64:625–639PubMedCrossRefGoogle Scholar
  53. 53.
    Larsen WG (1979) Allergic contact dermatitis to the perfume in Mycolog cream. J Am Acad Dermatol 1:131–133PubMedCrossRefGoogle Scholar
  54. 54.
    Larsen WG (1985) Perfume dermatitis. J Am Acad Dermatol 12(l):l–9Google Scholar
  55. 55.
    Levis WR, Whalen J J, et al. (1976) Specific blastogenesis and lymphokine production in DNCB-sensitive human leucocyte cultures stimulated with soluble and particulate DNP-containing antigens. Clin Exp Immunol 23:481–490PubMedGoogle Scholar
  56. 56.
    Mackinney AA, Stoklman F, et al. (1962) The kinetics of cell proliferation in cultures of human peripheral blood. Blood 19:349–358PubMedGoogle Scholar
  57. 57.
    Magaud J-P, Sargent I, et al. (1988) Detection of human white cell proliferative responses by immunoenzymatic measurement of bromodeoxyuridine uptake. J Immunol Meth 106:95–100CrossRefGoogle Scholar
  58. 58.
    Malanin G, Ohela K (1989) Allergic reactions to fragrance mix and its components. Contact Dermatitis 21:62–63PubMedCrossRefGoogle Scholar
  59. 59.
    McAteer JA, Davis J (1994) Basic cell culture technique and the maintenance of cell lines. In: Davis JM (ed) Basic cell culture A practical approach. Oxford University Press, New York, pp. 93–148Google Scholar
  60. 60.
    McDaniel WR, Marks JG (1979) Contact urticaria due to sensitivity to spray starch. Arch Dermatol 115:628PubMedCrossRefGoogle Scholar
  61. 61.
    Merk HF (1996) Skin metabolism in allergic contact dermatitis: the molecular basis. Springer Verlag, Berlin, Heidelberg, New York, pp 86–80Google Scholar
  62. 62.
    Mosman TR (1989) Thl and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145–173CrossRefGoogle Scholar
  63. 63.
    Mosmann TR, Cherwinski H, et al. (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136(7)2348–357Google Scholar
  64. 64.
    Müller G, Knop J, et al. (1996) Is cytokine expression responsible for differences between allergens and irritants? Am J Contact Dermatitis 7(3)177–184PubMedCrossRefGoogle Scholar
  65. 65.
    Muller PM, Lamparsky D (1991) Perfumes: art, science, and technology. Elsevier, New YorkCrossRefGoogle Scholar
  66. 66.
    Murphy E, Shibuya K, et al. (1986) Reversibility of T helper 1 and 2 populatoins is lost after longterm stimulation. J Exp Med 183:901–913CrossRefGoogle Scholar
  67. 67.
    Nowell PC (1960) Phytohemagglutinin, an initiator of mitosis in cultures of normal human leucocytes. Cancer Res 20:462–466PubMedGoogle Scholar
  68. 68.
    Nyfeler B, Pichler WJ (1997) The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity. Clin and Exp Allergy 27:175–181CrossRefGoogle Scholar
  69. 69.
    Oppenheim JJ (1969) Immunological relevance of antigen and antigen antibody complex induced lymphocyte transformation. Ann Allergy 27:305–315PubMedGoogle Scholar
  70. 70.
    Räsänen L, Tuomi M-L (1992) Diagnostic value of the lymphocyte proliferation test in nickel contact allergy and provocation in occupational coin dermatitis. Contact Dermatitis 27:250–254PubMedCrossRefGoogle Scholar
  71. 71.
    Reid CDL, Stackpoole A,et al. (1992) Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow. J Immunol 149:2681PubMedGoogle Scholar
  72. 72.
    Romani N, Gruner S, et al. (1994) Proliferating dendritic cell progenitors in human blood. J Exp Med 180:83–93PubMedCrossRefGoogle Scholar
  73. 73.
    Romani N, Reider D, et al. (1996) Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Meth 196:137–151Google Scholar
  74. 74.
    Rothenborg HW, Hjorth N (1968) Allergy to perfumes from toilet soaps and detergents in patients with dermatitis. Arch Dermatol 97:417–421PubMedCrossRefGoogle Scholar
  75. 75.
    Rytter M, Hausten U-F (1982) Hapten conjugation in the leukocyte migration inhibition test in allergic chromate eczema. Br J Dermatol 106:161–168PubMedCrossRefGoogle Scholar
  76. 76.
    Sallusto F, Lanzavecchia A (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor a. J Exp Med 179:1109–1118PubMedCrossRefGoogle Scholar
  77. 77.
    Scheinmann PL (1996) Allergic contact dermatitis to fragrance: a review. Am J Contact Dermatitis 7:65–76CrossRefGoogle Scholar
  78. 78.
    Serrano G, Pujol C, et al. (1989) Pigmented contact dermatitis caused by fragrances. J Am Acad Dermatol 21:1057–1060PubMedCrossRefGoogle Scholar
  79. 79.
    Sieben S, Al Masaoudi T, et al. (1998) Phase I and II enzyme expression in human monocytes, dendritic cells and keratinocytes (abstract 358). 12th International Symposium in Microsomes and Drug Oxidation, July 20-24, MontpellierGoogle Scholar
  80. 80.
    Sinigaglia F, Scheidegger D, et al. (1985) Isolation and characterization of Ni-specific T cell clones from patients with Ni-contact dermatitis. J Immuno 135:3929–3932Google Scholar
  81. 81.
    Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271–296PubMedCrossRefGoogle Scholar
  82. 82.
    Tio D (1976) A study on the clinical application of a direct leukocyte migration test in chromium contact allergy. Br J Dermatol 94:65–70PubMedCrossRefGoogle Scholar
  83. 83.
    Veien NK, Hattel T, et al. (1987) Dietary restrictions in the treatment of adult patients with eczema. Contact Dermatitis 17:223–227PubMedCrossRefGoogle Scholar
  84. 84.
    Von Blomerg-van der Flier BME, Bruynzeel DP, et al. (1988) Impact of 25 years of in vitro testing in allergic contact dermatitis. In: Frosch PJ, Dooms-Goossens A, Lachapelle J-M, et al. (eds) Current topics in contact dermatitis. Springer-Verlag, Berlin Heidelberg New York, pp. 569–577Google Scholar
  85. 85.
    Wheelock EF (1965) Interferon-like virus inhibitor induced in human leukocytes by phytohemagglutinin. Science 149:310–311CrossRefGoogle Scholar
  86. 86.
    Williams WR, Williams WJ (1982) Comparison of lymphocyte transformation and macrophage migration inhibition tests in the detection of beryllium sensitivity. J Clin Pathol 35:684–687PubMedCrossRefGoogle Scholar
  87. 87.
    Yamada M, Niwa Y, et al. (1972) Lymphocyte transformation in allergic contact dermatitis. Jpn J Dermatol 82:94–97Google Scholar

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© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • S. Sieben
  • B. Blömeke
  • H. F. Merk

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