Trends in Contrast Media pp 393-403 | Cite as
Cardiac Applications
Abstract
The concept of contrast echocardiography has been applied since 1968, when Gramiak and Shah reported improved delineation of aortic root structures by M-mode echocardiography (GRAMIAK and SHAH 1968; GRAMIAK et al. 1969). Other authors observed that the intracardiac injection of saline and indocyanine green dye resulted in dense ultrasonic reflectances (FEIGENBAUM et al. 1970). It was soon observed that similar ultrasonic densities could be produced by injecting almost any fluid. Moreover, intravenous injections were successful at opacifying the right-sided cardiac chambers, but not the left, owing to filtering of contrast by the lungs.
Keywords
Contrast Agent Coronary Blood Flow Contrast Echocardiography Harmonic Imaging Myocardial Contrast EchocardiographyPreview
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References
- Cotter B, Kwan OL, Cha YM, Dittrich H, Bhargava V, DeMaria AN (1994a) Dose-response characteristics, time-course, and hemodynamic response to QW3600, an ultrasonic contrast agent capable of myocardial opacification by intravenous injection. J Am Coll Cardiol 23:393A.CrossRefGoogle Scholar
- Cotter B, Kriett J, Perricone T, et al. (1994b) Detection of coronary artery occlusion by decreased myocardial opacification following intravenous injection of QW3600 (EchoGen®). Circulation 90:I–67.Google Scholar
- Cotter B, Duong A, Ohmori K, Kwan OL, DeMaria AN (1996a) Evaluation of QW7437, a third generation ultrasonic contrast agent capable of myocardial opacification: dose-response characteristics, time-course, hemodynamic response and detection of coronary occlusion (abstract). Circulation 94(Suppl I):I–319.Google Scholar
- Cotter B, Duong A, Kwan OL, Wheeler K, Nozaki S, DeMaria AN (1996b) Visualization of intramyocardial coronary vessels by contrast echocardiography, observations using AF0150 (Imagent® US) during second harmonic imaging. J Am Coll Cardiol 27:298A.CrossRefGoogle Scholar
- Crouse LJ (1992) Sonicated serum albumin in contrast echocardiography: improved segmental wall motion depiction and implications for stress echocardiography. Am J Cardiol 69:42H–45H.PubMedCrossRefGoogle Scholar
- Crouse LJ, Cheirif J, Hanly DE, et al. (1993) Opacification and border delineation improvement in patients with suboptimal endocardial border definition in routine echocardiography: results of the phase III Albunex multicenter trial. J Am Coll Cardiol 22:1494–1500.PubMedCrossRefGoogle Scholar
- DeMaria AN, Bommer W, Kwan OL, Riggs K, Smith M, Waters J (1984) In vivo correlation of thermodilution cardiac output and videodensitometric indicator-dilution curves obtained from contrast two-dimensional echocardiograms. J Am Coll Cardiol 3:999–1004.PubMedCrossRefGoogle Scholar
- DeMaria AN, Dittrich H, Kwan OL, Kimura B (1993) Myocardial opacification produced by peripheral venous injection of a new ultrasonic contrast agent. Circulation 88:I–401.Google Scholar
- Dittrich HC, Bales GL, Kuvelas T, Hunt RM, McFerran BA, Greener Y (1995) Myocardial contrast echocardiography in experimental coronary artery occlusion with a new intravenously administered contrast agent. J Am Soc Echocardiogr 8:465–474.PubMedCrossRefGoogle Scholar
- Feigenbaum H, Stone JM, Lee DA, Nasser WK, Chang S (1970) Identification of ultrasound echoes from the left ventricle by use of intracardiac injections of indocyanine green. Circulation 41:615–621.PubMedGoogle Scholar
- Ge S, Giraud G, Shiota T (1995) Microcirculatory flow dynamics during peripheral intravenous injection of EchoGen: microscopic visualization of mesenteric microcirculatory flow with simultaneously transthoracic echo imaging in cats. J Am Coll Cardiol 23:293A.Google Scholar
- Gramiak R, Shah PM (1968) Echocardiography of the aortic root. Invest Radiol 3:356–366.PubMedCrossRefGoogle Scholar
- Gramiak R, Shah PM, Kramer DH (1969) Ultrasound cardiography: contrast studies in anatomy and function. Radiology 92:939–948.PubMedGoogle Scholar
- Grauer SE, Xu J, Pantely GA, et al. (1996) MRX 115, an echocardiographic contrast agent, produces myocardial opacification after intravenous injection in primates: studies before and after occlusion of left anterior descending coronary artery. Acad Radiol 3 Suppl 2:S405–S406.PubMedCrossRefGoogle Scholar
- Grayburn PA, Erickson JM, Escobar J, Womack L, Velasco CE (1995) Peripheral intravenous myocardial contrast echocardiography using a 2% dodecafluoropentane emulsion: identification of myocardial risk area and infarct size in the canine model of ischemia. J Am Coll Cardiol 26:1340–1347.PubMedCrossRefGoogle Scholar
- Ito H, Maruyama A, Iwakura K, et al. (1996) Clinical implications of the “no reflow” phenomenon. A predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. Circulation 93:223–228.Google Scholar
- Kaul S, Jayaweera AR (1993) Myocardial contrast echocardiography has the potential for the assessment of coronary microvascular reserve [editorial; comment]. J Am Coll Cardiol 21:356–358.PubMedCrossRefGoogle Scholar
- Kaul S, Senior R, Dittrich H, Rava U, Khattar R, Lahiri A (1997) Detection of coronary artery disease with myocardial contrast echocardiography: comparison with 99mTc-sestamibi single-photon emission computed tomography. Circulation 96:785–792.PubMedGoogle Scholar
- Lechat P, Mas JL, Lascualt G (1988) Prevalence of patent foramen ovale in patients with stroke. N Engl J Med 318:1148–1152.PubMedCrossRefGoogle Scholar
- Main ML, Escobar JF, Hall SA, Grayburn PA (1997) Safety and efficacy of QW7437, a new fluorocarbon-based echocardiographic contrast agent. J Am Soc Echocardiogr 10:798–794.PubMedCrossRefGoogle Scholar
- Meltzer RS, Tickner EG, Sahines TP, Popp RL (1980) The source of ultrasound contrast effect. JCU J Clin Ultrasound 8:121–127.PubMedCrossRefGoogle Scholar
- Miller DL (1981) Ultrasonic detection of resonant cavitation bubbles in a flow tube by their second-harmonic emissions. Ultrasonics 19:217–224.CrossRefGoogle Scholar
- Mulvagh SL, Foley DA, Aeschbacher BC, Klarich KK, Seward JB (1996) Second harmonic imaging of an intravenously administered echocardiographic contrast agent: visualization of coronary arteries and measurement of coronary blood flow. J Am Coll Cardiol 27:1519–1525.PubMedCrossRefGoogle Scholar
- Ohmori K, Cotter B, Kwan OL, Mizushige K, DeMaria AN (1997) Relation of contrast echo intensity and flow velocity to the amplification of contrast opacification produced by intermittent ultrasound transmission. Am Heart J 134:1066–1074.PubMedCrossRefGoogle Scholar
- Porter TR, Xie F (1995) Transient myocardial contrast after initial exposure to diagnostic ultrasound pressures with minute doses of intravenously injected microbubbles. Demonstration and potential mechanisms. Circulation 92:2391–2395.Google Scholar
- Porter TR, D’Sa A, Pesko L, et al. (1993a) Usefulness of myocardial contrast echocardiography in detecting the immediate changes in anterograde blood flow reserve after coronary angioplasty. Am J Cardiol 71:893–896.PubMedCrossRefGoogle Scholar
- Porter TR, D’Sa A, Turner C, et al. (1993b) Myocardial contrast echocardiography for the assessment of coronary blood flow reserve: validation in humans [see comments]. J Am Coll Cardiol 21:349–355.PubMedCrossRefGoogle Scholar
- Porter TR, Kricsfeld A, Deligonul U, Xie F (1996) Detection of regional perfusion abnormalities during adenosine stress echocardiography with intravenous perfluorocarbon-exposed sonicated dextrose albumin. Am Heart J 132(1 Pt l):41–47.PubMedCrossRefGoogle Scholar
- Porter TR, Li S, Kricsfeld D, Armbruster RW (1997) Detection of myocardial perfusion in multiple echocardiographic windows with one intravenous injection of microbubbles using transient response second harmonic imaging. J Am Coll Cardiol 29:791–799.PubMedCrossRefGoogle Scholar
- Rovai D, Nissen SE, Elion JE (1987) Contrast echo washout curves from the left ventricle: application of basic principles of indicator-dilution theory and calculation of ejection fraction. J Am Coll Cardiol 10:125–134.PubMedCrossRefGoogle Scholar
- Sabia PJ, Powers ER, Jayaweera AR, Ragosta M, Kaul S (1992) Functional significance of collateral blood flow in patients with recent acute myocardial infarction. A study using myocardial contrast echocardiography. Circulation 85: 2080–2089.Google Scholar
- Schrope B, Newhouse VL (1993) Second harmonic ultrasonic blood perfusion measurement. Ultrasound Med Biol 19:567–579.PubMedCrossRefGoogle Scholar
- Schrope B, Newhouse VL, Uhlendorf A (1992) Simulated capillary blood flow measurement using a non line ultrasonic contrast agent. Ultrason Imaging 14:134–158.PubMedCrossRefGoogle Scholar
- Smith MK, Kwan OL, Reiser J, DeMaria AN (1983) Superior intensity and reproducibility of SHU-454, a new right heart contrast agent. J Am Coll Cardiol 3:992–998.CrossRefGoogle Scholar
- Terasawa A, Miyatake K, Nakatani S, Yamagishi M, Matsuda H, Beppu S (1993) Enhancement of Doppler flow signals in the left heart chambers by intravenous injection of sonicated albumin. J Am Coll Cardiol 21:737–742.PubMedCrossRefGoogle Scholar
- Valdes-Cruz L, Sahn DJ (1984) Ultrasonic contrast studies for the detection of cardiac shunts. J Am Coll Cardiol 3:978–985.PubMedCrossRefGoogle Scholar
- Villanueva FS, Jankowski RJ, Manaugh C, Wagner WR (1997) Albumin microbubble adherence to human coronary endothelium: implications for assessment of endothelial function using myocardial contrast echocardiography. J Am Coll Cardiol 30:689–693.PubMedCrossRefGoogle Scholar
- Villanueva FS, Jankowski RJ, Klibanov S, et al. (1998) Micro-bubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. Circulation 98:1–5.PubMedGoogle Scholar
- von Bibra H, Becher H, Firschke C, Schlief R, Emslander HP, Schomig A (1993) Enhancement of mitral regurgitation and normal left atrial color Doppler flow signals with peripheral venous injection of a saccharide-based contrast agent. J Am Coll Cardiol 22:521–528.CrossRefGoogle Scholar
- von Bibra H, Sutherland G, Becher H, Neudert J, Nihoyanno-poulos P (1995) Clinical evaluation of left heart Doppler contrast enhancement by a saccharide-based transpul-monary contrast agent. The Levovist Cardiac Working Group. J Am Coll Cardiol 25:500–508.Google Scholar
- Wei K, Skyba DM, Firschke C, Jayaweera AR, Lindner JR, Kaul S (1997) Interactions between microbubble and ultrasound: in vitro and in vivo observations. J Am Coll Cardiol 29:1081–1088.PubMedCrossRefGoogle Scholar
- Wei K, Jayaweera AR, Firoozan S, Linka A, Skyba DM, Kaul S (1998) Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation 97:785–792.Google Scholar
- Yasu T, Schmid-Schoenbein GW, Cotter B, DeMaria AN (1997) Intravital microscopic study of QW7437, a new dodecafluoropentane contrast agent: potential for prolonged myocardial enhancement (abstract). Circulation 96(Suppl I):I–214.Google Scholar