Advertisement

Markers of Inflammation for Prognosis and Control of Therapeutic Success in Patients with Abdominal Sepsis — Options for Using Adjuvant Intravenous Immunoglobulins

  • H. B. Reith
  • U. Mittelkötter

Abstract

Sepsis is first of all a clinical diagnosis and is based on objective clinical data according to the ACCP/SCCM-definitions from 1991, which defined sepsis as a situation with an identified or obvious infection and the criteria of systemic inflammatory response syndrome (SIRS). These criteria are temperature more than 38.4 °C or less than 36.0 °C, tachycardia of more than 90 heartbeats/minute, tachypnoea of more than 20 breaths/minute or the need for artificial ventilation and a leukocyte count of more than 12000/µl or less than 4000/µl.

Keywords

Septic Shock Severe Sepsis Systemic Inflammatory Response Syndrome Intravenous Immunoglobulin Simplify Acute Physiology Score 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alejandria MM, Lansang MA, Dans LF, Mantaring JBV (1999 and update 2000) Intravenous immunoglobulin for treating sepsis and septic shock (Cochrane-review) The Cochrane Library 3 Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C (1993) High serum procalcitonin concentration in patients with sepsis and infection. Lancet 341: 515Google Scholar
  2. Becker KL, Nash DR, Silva OL, Snider RH, Moore CF (1981) Increased serum and urinary calcitonin levels in patients with pulmonary disease. Chest 79: 211PubMedCrossRefGoogle Scholar
  3. Beier W (1994) Procalcitonin (ProCt) — ein innovativer Inflammationsparameter mit prognostischen Eigenschaften. Anästh Intensivmed 36: XVIII, (editorial)Google Scholar
  4. Bein T, Unertl K (1993) Möglichkeiten and Grenzen von Score-Systemen in der Intensivmedizin. Anästhesiol. Intensivmed. Notfallmed. Schmerzther. 28: 476–483Google Scholar
  5. Bone RC (1991) The pathogenesis of sepsis. Ann Intern Med 115: 457PubMedGoogle Scholar
  6. Brunkhorst FM, Forycki ZF, Beier W, Wagner J (1993) Discrimination of infectious and noninfectious etiologies of the adult respiratory distress syndrome (ARDS) with procalcitonin immunoreactivity. Clin Intensive Care 3 (suppl); 12Google Scholar
  7. Chen JY (1996) Intravenous immunoglobulin in the treatment of full term and premature newborns with sepsis. J Formos Med Assoc 24: 733–42Google Scholar
  8. Concato J, Shah N, Horwitz RI (2000) Randomized, controlled trials, observational studies, and the hierarchy of research design. NEJM; 342 (25): 1887–1892PubMedCrossRefGoogle Scholar
  9. Döcke WD, Randow F, Syrbe U, Krausch D, Asadullah K, Reinke P, Volk HD, Kox W (1997) Monocyte deactivation in septic patients: restoration by IFN-y treatment. Nature Medicine 3: 678–681PubMedCrossRefGoogle Scholar
  10. Garbett ND, Munro CS, Cole PJ (1989) Opsonic activity of an new intravenous immunoglobulin preparation: pentaglobin compared with sandoglobulin. Clinical Experimental Immunol, 76: 3–12Google Scholar
  11. Goris RJA, Boekhorst TPA, Nuytinck JKS (1985) Multiple organ failure. Arch Surg 118: 1109Google Scholar
  12. Grundmann R, Hornung M (1988) Immunoglobulintherapy in patients with endotoxinemia and postoperative sepsis–a prospective randomized study. Progress in clinical and biological Research 339–349Google Scholar
  13. Haupt W, Fritsche H, Hohenberger W, Zirngibl H (1996) Selective cytokine release induced by serum and separated plasma from septic patients. Eur J Surg 162: 769PubMedGoogle Scholar
  14. Heney D, Lewis IJ, Evans SW, Banks R, Bailey CC, Whicher JT (1992) Interleukin-6 and its relationship to C-reactive protein and fever in children with febrile neutropenia. J Infect Dis 165: 886PubMedCrossRefGoogle Scholar
  15. Heuer HO, Darius H, Lohmann HF, Meyer J, Schierenberg M, Treese N (1991) Platelet-activating factor type activity in plasma from patients with septicemia and other diseases. Lipids 26: 1381PubMedCrossRefGoogle Scholar
  16. Huttemeier PC, Ritter EF, Benveniste H (1993) Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxin rats. Am J Physiol 265: 4767Google Scholar
  17. Joyce CD, Fiscus RR, Wang X, Dries DJ, Morris RC, Prinz RA (1990) Calcitonin related peptide levels are elevated in patients with sepsis. Surgery 108: 1097PubMedGoogle Scholar
  18. Le Gall JR, Lemeshow S, Saulnier F (1993) A New Simplified Acute Physiology Score ( SAPS II) Based on a European/North American Multicenter Study. JAMA 270 2957–2963PubMedCrossRefGoogle Scholar
  19. Marshall JC (2000) Clinical trials of mediator-directed therapy in sepsis: what have we learned? Intensive Care Med. 26: S75–83PubMedCrossRefGoogle Scholar
  20. Mimos O, Benoist JF, Edouard AR, Assicot M, Bohoun C, Samii K (1998) Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome. Intensive Care Med 24: 185–188CrossRefGoogle Scholar
  21. NIH Consensus conference (1990) Intravenous immunoglobulins. Prevention and treatment of disease. JAMA 264: 3189–3193CrossRefGoogle Scholar
  22. Nylen ES, O’Neill WO, Jordan MH et al. (1992) Serum procalcitonin as an index of inhalation injury in burns. Horm Metab Res 24: 439PubMedCrossRefGoogle Scholar
  23. Opal SM, Cross AS, Bhattacharjee AK, Visvanathan K, Zabriski JB (1999) Immunoprophylaxis against bacterial sepsis. Sepsis 3: 225–234CrossRefGoogle Scholar
  24. Rangel-Frausto MS, Pittet D, Costigan, RN, Hwang T, Davis, CS, Wenzel, RP (1995) The natural history of the systemic inflammatory response syndrome (SIRS) JAMA, 273: 117–123PubMedCrossRefGoogle Scholar
  25. Reist K, Hilfiker O, Stepniewski MS et al. (1996) Sepsis-Score in der operativen Intensivmedizin. Anästhesiol Intensivmed Notfallmed Schmerzther 31Google Scholar
  26. Reith HB, Dittrich H, Haarmann W, Smektala R, Dohle J, Kozuschek W (1996) Adjuvante Therapie der Peritonitis und ihrer septischer Verlaufsformen mit Taurolidin - eine prospektive randomisierte Untersuchung. Chir Gastroenterologie 12: 358CrossRefGoogle Scholar
  27. Reith HB, Mittelkötter U, Wagner R, Thiede A (2000) Procalcitonin (PCT) in patients with abdominal sepsis. Intensive Care Med. 26: S 165–169Google Scholar
  28. Rosman C, Grond J, Buurman WA et al. (1993) Fish oil increases the release of tumor necrosis factor and interleukin-6 and has no effect on the incidence of multiple organ failure in rats with peritonitis. Eur J Surg 159: 563PubMedGoogle Scholar
  29. Schedel I, Dreikhausen U, Nentwig B, Hockenschnieder M, Rauthmann D, Balikcioglu S, Coldewey R, Deicher H (1991) Treatment of gram-negative septic shock with an immunoglobulin preparation: a prospective randomized clinical trial. Clinical Care Med, 10: 1104–1113CrossRefGoogle Scholar
  30. Werdan K (1999) Immunoglobulins in sepsis: therapeutic use of immunoglobulins. Sepsis 3: 239–245CrossRefGoogle Scholar
  31. Zanetti G, Calandra T (1997) Intravenous immunoglobulins and granulocyte colony-stimulating factor for the management of infection in intensive care units. Curr Opin Crit Care 3: 342–347Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • H. B. Reith
  • U. Mittelkötter

There are no affiliations available

Personalised recommendations