The HCMV Gene Products US2 and US11 Target MHC Class I Molecules for Degradation in the Cytosol

  • F. J. van der Wal
  • M. Kikkert
  • E. Wiertz
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 269)


Over millions of years of coevolution with their hosts, viruses have developed highly effective strategies to elude the host immune system. The degradation of major histocompatibility complex (MHC) class I heavy chains by human cytomegalovirus (HCMV) is an example of this. Two HCMV proteins, US2 and US11, target newly synthesized MHC class I heavy chains for destruction via a pathway that involves ubiquitin-dependent retrograde transport, or “dislocation”, of the heavy chains from the ER to the cytosol, where the proteins are degraded by proteasomes. In this review, US2- and US11-mediated degradation of MHC class I heavy chains is discussed in relation to data concerning the degradation of other ER luminal proteins. A new, unified model for translocon-facilitated dislocation and degradation of MHC class I heavy chains is presented.


Heavy Chain Major Histocompatibility Complex Class Cystic Fibrosis Transmembrane Conductance Regulator Protein Disulfide Isomerase Endoplasmic Reticulum Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • F. J. van der Wal
    • 1
  • M. Kikkert
    • 1
  • E. Wiertz
    • 1
  1. 1.Department of Medical MicrobiologyLeiden University Medical CenterLeidenThe Netherlands

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