Molecular Epidemiology of Japanese Encephalitis Virus

  • M. R. Holbrook
  • A. D. T. Barrett
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 267)

Abstract

Japanese encephalitis (JE) virus causes an encephalitic disease in humans that is characterized by a wide range of symptoms from a nonspecific febrile illness to convulsions, seizure, and death (Solomon et al. 2000). Approximately 30% of patients presenting at hospital with JE will succumb to the disease and about 50% of those who survive will have severe neurological sequelae (Solomon et al. 2000). The JE virus is carried by mosquitoes, primarily Culex species, and is endemic from tropical to temperate regions of Asia and Australasia. JE virus is generally considered to circulate in an endemic cycle in southern regions of Asia whereas the virus tends to have a more epidemic epidemiological pattern in northern Asia with outbreaks occurring during the summer months (Vaughn and Hoke 1992). The virus infects a number of animal hosts, most importantly pigs, which act as amplifying hosts and are found in high numbers throughout rural Asia. The first isolate of JE virus, and the prototype strain, was isolated in 1935 in Tokyo from a human brain and is designated the Nakayama strain. Since that time, a large number of JE virus isolates have been identified from a wide range of geographical locales throughout Asia, Indonesia, and most recently, northern Australia. Many of these viruses have been analyzed serologically and/or genetically to examine the distribution of the virus strains over both temporal and geographical boundaries. To date, the complete genome of 20 strains of JE virus have been sequenced including the first isolate from Australia (Williams et al. 2000).

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References

  1. Ali A, Igarashi A, Paneru LR, Hasebe F, Morita K, Takagi. M, Suwonkerd W, Tsuda Y, Wada Y (1995) Characterization of two Japanese encephalitis virus strains isolated in Thailand. Arch Virol 140: 1557–1575Google Scholar
  2. Ali A, Igarashi A (1997) Antigenic and genetic variations among Japanese encephalitis virus strains belonging to genotype 1 Microbiol Immunol 41: 241–252Google Scholar
  3. Banerjee K (1986) Certain characteristics of Japanese encephalitis virus strains by neutralization test. Indian J Med Res 83: 243–250PubMedGoogle Scholar
  4. Banerjee K, Ranadive SN (1989) Oligonucleotide fingerprint analysis of Japanese encephalitis virus strains of different geographical origin. Indian J Med Res 89: 201–216PubMedGoogle Scholar
  5. Calisher CH, Karabatsos N, Dalrymple JM, Shope RE, Portefield JS, Westaway EG, Brandt WE (1989) Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyclonal antisera. J Gen Virol 70: 37–43PubMedCrossRefGoogle Scholar
  6. Chamberlain RW (1980) Epidemiology of arthropod-borne toga-viruses: the role of arthropods as hosts and vectors and of vertebrate hosts in natural transmission cycles. In: Schlessinger RW (ed) The Togaviruses. Academic Press, New York. pp 175–227Google Scholar
  7. Chen W-R, Tesh RB, Rico-Hesse R (1990) Genetic variation of Japanese encephalitis virus in nature. J Gen Virol 71: 2915–2922PubMedCrossRefGoogle Scholar
  8. Chen WR, Rico-Hesse R, Tesh RB (1992) A new genotype of Japanese encephalitis virus from Indonesia. Am J Trop Med Hyg 47: 61–69PubMedGoogle Scholar
  9. Chung YJ, Nam JH, Ban SJ, Cho HW (1996) Antigenic and genetic analysis of Japanese encephalitis viruses isolated from Korea. Am J Trop Med Hyg 55: 91–97PubMedGoogle Scholar
  10. Ghosh SN, Sathe PS, Sarthi SA, Cecilia D, Dandawate CN, Athawale SS, Pant U (1989) Epitope analysis of strains of Japanese encephalitis virus by monoclonal antibodies. Indian J Med Res 89: 368–375PubMedGoogle Scholar
  11. Hale JH, Lee LH (1954) A serological investigation of six encephalitis viruses isolated in Malaya. Br J Exp Pathol 35: 426–433PubMedGoogle Scholar
  12. Hanna JN, Ritchie SA, Phillips DA, Shield J, Bailey MC, Mackenzie JS, Poidinger M, McCall B, Mills RI (1996) An outbreak of Japanese encephalitis in the Torres Strait, Australia, 1995. Med J Aust 165: 256–260PubMedGoogle Scholar
  13. Hasegawa H, Yoshida M, Fujita S, Kobayashi Y (1994) Comparison of structural proteins among antigenically different Japanese encephalitis virus strains. Vaccine 12: 841–844PubMedCrossRefGoogle Scholar
  14. Hasegawa H, Yoshida M, Kobayashi Y, Fujita S (1995) Antigenic analysis of Japanese encephalitis viruses in Asia by using monoclonal antibodies. Vaccine 13: 1713–1721PubMedCrossRefGoogle Scholar
  15. Heinz FX, Allison SL (2000) Structures and mechanisms in flavivirus fusion. Adv Virus Res 55: 231–269PubMedCrossRefGoogle Scholar
  16. Hori H (1986) Oligonucleotide fingerprint analysis on Japanese encephalitis (JE) virus strains of different geographical origins. Trop Med 28: 179–190Google Scholar
  17. Hori H, Morita K, Igarashi A (1986) Oligonucleotide fingerprint analysis on Japanese encephalitis virus strains isolated in Japan and Thailand. Acta Virol 30: 353–359PubMedGoogle Scholar
  18. Huang CH (1982) Studies of Japanese encephalitis in China. Adv. Virus Res. 27: 71–101CrossRefGoogle Scholar
  19. Huong VTQ, Ha DQ, Deubel V (1993) Genetic study of Japanese encephalitis viruses from Vietnam. Am J Trop Med Hyg 49: 538–544PubMedGoogle Scholar
  20. Jan LR, Yueh YY, Wu YC, Horng CB, Wang GR (2000) Genetic variation of Japanese encephalitis virus in Taiwan. Am J Trop Med Hyg. 62: 446–452PubMedGoogle Scholar
  21. Kedarnath N, Dayaraj C, Gadkari DA, Dandawate CN, Goverdhan M K, Ghosh SN (1986) Monoclonal antibodies against Japanese encephalitis. Indian J Med Res 84: 125–133PubMedGoogle Scholar
  22. Kimura-Korda J, Yasui K (1983) Topographical analysis of antigenic determinants on envelope glyco-protein V3 (E) of Japanese encephalitis virus, using monoclonal antibodies. J Virol 45: 124–132Google Scholar
  23. Kimura-Korda J, Yasui K (1986) Antigenic comparison of envelope protein E between Japanese en-cephalitis virus and some other flaviviruses using monoclonal antibodies. J Gen Virol 67: 2663–2672Google Scholar
  24. Kobayashi Y, Hasegawa H, Oyama T, Tamai T, Kusaba T (1984) Antigenic analysis of Japanese encephalitis virus by using monoclonal antibodies. Infect Immun 44: 117–123PubMedGoogle Scholar
  25. Kobayashi Y, Hasegawa H, Yamauchi T (1985) Studies on the antigenic structure of Japanese encephalitis virus using monoclonal antibodies. Microbiol Immunol 29: 1069–1082PubMedGoogle Scholar
  26. Kolaskar AS, Tongaonkar PC (1990) A semi-empirical method for prediction of antigenic determinants on protein antigens. FEBS Lett 276: 172–174PubMedCrossRefGoogle Scholar
  27. Kolaskar AS, Kulkarni-Kale U (1999) Prediction of three-dimensional structure and mapping of con-formational epitopes of envelope glycoprotein of Japanese encephalitis virus. Virology 261: 31–42PubMedCrossRefGoogle Scholar
  28. Ma SP, Arakaki S, Makino Y, Fukunaga T (1996) Molecular epidemiology of Japanese encephalitis virus in Okinawa. Microbiol Immunol 40: 847–855PubMedGoogle Scholar
  29. Madrid AT, Porterfield JS (1974) The flaviviruses (group B arboviruses): a cross-neutralization study. J Gen Virol 23: 91--96PubMedCrossRefGoogle Scholar
  30. Mandl CW, Guirakhoo F, Holzman H, Heinz FX, Kunz C (1989) Antigenic structure of the flavivirus envelope protein E at the molecular level, using tick-borne encephalitis virus as a model. J Virol 63: 564–571Google Scholar
  31. Mangada MNM, Takegami T (1999) Molecular characterization of the Japanese encephalitis virus representative immunotype strain Ja GAr 01. Virus Res 59: 101–112PubMedCrossRefGoogle Scholar
  32. Nam JH, Chung YJ, Ban SJ, Kim EJ, Park YK, Cho HW (1996) Envelope gene sequence variation among Japanese encephalitis viruses isolated in Korea. Acta Virol 40: 303–309PubMedGoogle Scholar
  33. Ni H, Barrett ADT (1996) Molecular differences between wild-type Japanese encephalitis virus strains of high and low mouse neuroinvasiveness. J Gen Virol 77: 1449–1455PubMedCrossRefGoogle Scholar
  34. Okuno Y, Okada T, Kondo A, Suzuki M, Kobayashi M, Oya A (1968) Immunotyping of different strains of Japanese encephalitis virusby antibody absorption, hemagglutionation-inhibition and complement-fixation tests. Bull WHO 38: 547–563PubMedGoogle Scholar
  35. Paranjpe S, Banerjee K (1996) Phylogenetic analysis of the envelope gene of Japanese encephalitis virus. Virus Res 42: 107–117PubMedCrossRefGoogle Scholar
  36. Parker JM, Guo D, Hodges RS (1986) New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: Correlation of predicted surface residues with antigenicity and X-ray derived accessible sites. Biochemistry 25: 5425–5432PubMedCrossRefGoogle Scholar
  37. Porterfield JS (1980) Antigenic characteristics and classification of Togaviridae. In: Schlessinger RW (ed) The Togaviruses. Academic Press, New York. pp 13–46Google Scholar
  38. Rey FA, Heinz FX, Mandl CW, Kunz C, Harrison SC (1995) The envelope glycoprotein from tick-borne encephalitis at 2 A resolution. Nature 375: 291–298PubMedCrossRefGoogle Scholar
  39. Satake Y, Hasegawa H, Yoshida M, Kobayashi Y (1994) Isolation of anti-Beijing-1 group-specific monoclonal antibody and antigenic analysis of Japanese encephalitis viruses in India. Vaccine 12: 723–726PubMedCrossRefGoogle Scholar
  40. Solomon T, Dung NM, Kneen R, Gainsborough M, Vaughn DW, Khanh VT (2000) Japanese encephalitis. J Neurol Neurosurg Psychiatry 68: 405–415PubMedCrossRefGoogle Scholar
  41. Sumiyoshi H, Mori C, Fuke I, Morita K, Kuhara S, Kondou J, Kikuchi Y, Nagamatu H, Igarashi A (1987) Complete nucleotide sequence of the Japanese encephalitis virus genome RNA. Virology 161: 497–510PubMedCrossRefGoogle Scholar
  42. Tsarev SA, Sanders ML, Vaughn DW, Innis BL (2000) Phylogenetic analysis suggests only one serotype of Japanese encephalitis virus. Vaccine 18: 36–43PubMedCrossRefGoogle Scholar
  43. Tsuchie H, Oda K, Vyythilingam I, Thayan R, Vijayamalar B, Sinniah M, Hossain MM, Kurimura T, Igarashi A (1994) Genetic study of Japanese encephalitis virus in Malaysia. Japan. J Med Sci Biol 47: 101–107Google Scholar
  44. Tsuchie H, Oda K, Vythilingam I, Thayan R, Vijayamalar B, Sinniah M, Singh J, Wada T, Tanaka H, Kurimura T, Igarashi A (1997) Genotypes of Japanese encephalitis virus isolated in three states of Malaysia. Am J Trop Med Hyg 56: 153–158PubMedGoogle Scholar
  45. Vaughn DW, Hoke CH (1992) The epidemiology of Japanese encephalitis virus: prospects for prevention. Epidemiol Rev 14: 197–221PubMedGoogle Scholar
  46. Vrati S, Agarwal V, Malik P, Wani SA, Saini M (1999) Molecular characterization of an Indian isolate of Japanese encephalitis virus that shows an extended lag phase during growth. J Gen Virol 80: 1665–1671PubMedGoogle Scholar
  47. Williams DT, Wang L-F, Daniels PW, Mackenzie JS (2000) Molecular characterization of the first Australian isolate of Japanese encephalitis virus, the FU strain. J Gen Virol 81: 2471–2480PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • M. R. Holbrook
    • 1
  • A. D. T. Barrett
    • 1
  1. 1.Department of Pathology and WHO Collabrating Center for Tropical DiseasesUniversity of Texas Medical BranchGalvestonUSA

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