Biology of Stem Cell Mobilization Induced by Cytokines
Mobilized autologous or allogeneic hematopoietic progenitor cells are currently the preferential source for transplantation in the treatment of a variety of malignant and non-malignant diseases. In spite of the widespread clinical use of these peripheral blood stem cells the mechanisms underlying mobilization are still largely unknown.
KeywordsPeripheral Blood Stem Cell Hematopoietic Progenitor Cell Stem Cell Mobilization Peripheral Blood Progenitor Cell Nitor Cell
Unable to display preview. Download preview PDF.
- 1.Crawford J, Ozer H, Stoller R, Johnson D, Lyman G, Tabbara I, Kris M, Grous J, Picozzi V, Rausch G, Smith R, Gradishar W, Yahanda A, Vincent M, Stewart M, Glaspy J: Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. N Engl J Med, 325:164, 1991PubMedCrossRefGoogle Scholar
- 8.Pruijt JFM, Fibbe WE, Laterveer L, Willemze R, Masure S, Paemen L, Opdenakker G: Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by antibodies to the metalloproteinase gelatinase B. Proc Natl Acad Sci USA 96:10863, 1999PubMedCrossRefGoogle Scholar
- 9.Levesque JP, Takamatsu Y, Nilsson SK, Haylock DN, Simmons PJ: Mobilization of hemopoietic progenitor cells into peripheral blood is associated with VCAM-1 proteolytic cleavage in the bone marrow. Blood 96(11):945 (abstract), 2000Google Scholar