Pathways for Oxidative Tissue Injury by Myeloperoxidase

  • Jay W. Heinecke
Conference paper

Abstract

Oxidant generation by phagocytes may represent an important pathway for tissue damage in pathological conditions ranging from atherosclerosis to ischemia reperfusion injury and cancer. The pathway for oxidant generation by activated phagocytic white blood cells begins with a membrane-associated NADPH oxidase that generates superoxide [1, 2]. Superoxide spontaneously or enzymatically dismutates to form hydrogen peroxide, a relatively unreactive oxidant. However, the oxidative potential of hydrogen peroxide is amplified by myeloperoxidase, a secreted heme protein [1, 2]. The enzyme represents an attractive candidate for monitoring phagocyte-mediated damage because it generates several distinct oxidants that covalently modify cellular targets.

Keywords

Human Neutrophil Reactive Aldehyde Tyrosyl Radical Molecular Chlorine Hydroxy Amino 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

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  • Jay W. Heinecke

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