Adenovirus-mediated myocardial gene therapy

  • J. K. Donahue
Chapter

Abstract

The introduction of genetic material to the heart showed promise when adenovirus vectors were demonstrated to easily and efficiently transfer reporter genes to isolated cardiac myocytes in vitro [17, 18]. Numerous possibilities for the new technology were readily apparent. The most obvious was the replacement of genetic defects in inherited disorders, such as the long QT syndrome and several types of hypertrophic and dilated cardiomyopathies. Even more exciting, however, was the prospect of using this technology to modify more common, acquired diseases including ischemic diseases, acquired cardiomyopathies and arrhythmias. Most of these diseases affect every cell in the heart, so therapeutic applications would require delivery of the gene of interest to a majority of the myocytes in a homogeneous pattern throughout the heart.

Keywords

Gene Transfer Virus Concentration Virus Attachment Coxsackie Adenovirus Receptor Calcium Paradox 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Barr E, Carroll J, Kalynych AM, Tripathy SK, Kozarsky K, Wilson JM, Leiden JM (1994) Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. Gene Therapy 1:51–58PubMedGoogle Scholar
  2. 2.
    Bergelson JM, Cunningham JA, Droguett G, Kurtjones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW (1997) Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275:1320–1323PubMedCrossRefGoogle Scholar
  3. 3.
    Breil I, Koch T, Belz M, Vanackern K, Neuhof H (1997) Effects of bradykinin, histamine, and serotonin on pulmonary vascular resistance and permeability. Acta Physiologica Scandinavica 159:189–198PubMedCrossRefGoogle Scholar
  4. 4.
    Chapman RA (1987) Calcium channels, the sodium-calcium exchange and intracellular sodium in the predisposition of the heart to the calcium paradox. Biomed Biochem Acta 46:S512–S516Google Scholar
  5. 5.
    Chardonnet Y, Dales S (1970) Early events in the interaction of adenoviruses with HeLa cells: I. penetration of type 5 and intracellular release of the DNA genome. Virology 40:462–477PubMedCrossRefGoogle Scholar
  6. 6.
    Chen HH, Mack LM, Kelly R, Ontell M, Kochanek S, Clemens PR (1997) Persistence in muscle of an adenoviral vector that lacks all viral genes. Proc Natl Acad Sci USA 94:1645–1650PubMedCrossRefGoogle Scholar
  7. 7.
    Chroboczek J, Bieber F, Jacrot B (1992) The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2. Virology 186:280–285PubMedCrossRefGoogle Scholar
  8. 8.
    de Roos WK, Fallaux FJ, Marinelli AW, Lazaris-Karatzas A, von Geusau AB, van der Eb MM, Cramer SJ, Terpstra OT, Hoeben RC (1997) Isolated-organ perfusion for local gene delivery: efficient adenovirus-mediated gene transfer into the liver. Gene Ther 4:55–62PubMedCrossRefGoogle Scholar
  9. 9.
    Donahue JK, Kikkawa K, Johns DC, Marban E, Lawrence JH (1997) Ultrarapid, highly efficient viral gene transfer to the heart. Proc Natl Acad Sci USA 94:4664–4668PubMedCrossRefGoogle Scholar
  10. 10.
    Fechner H, Haack A, Wang H, Wang X, Eizema K, Pauschinger M, Schoemaker R, Veghel R, Houtsmuller A, Schultheiss HP, Lamers J, Poller W (1999) Expression of Coxsackie adenovirus receptor and alpha-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers. Gene Therapy 6:1520–1535PubMedCrossRefGoogle Scholar
  11. 11.
    Ghosh-Choudhury G, Haj-Ahmad Y, Graham FL (1987) Protein IX, a minor component of the human adenovirus capsid, is essential for the packaging of full length genomes. EMBO J 6:1733–1739PubMedGoogle Scholar
  12. 12.
    Gojo S, Kitamura S, Niwaya K, Yoshida Y, Sakaguchi H, Kawachi K (1996) Ex vivo gene transfer to transplanted heart grafts using adenoviral vector. Transplantation Proceedings 28:1818–1819PubMedGoogle Scholar
  13. 13.
    Graham FL, Prevec L (1995) Methods for construction of adenovirus vectors. Mol Biotechnol 3:207–220PubMedCrossRefGoogle Scholar
  14. 14.
    Guzman RJ, Lemarchand P, Crystal RG, Epstein SE, Finkel T (1993) Efficient gene transfer into myocardium by direct injection of adenovirus vectors. Circ Res 73:1202–1207PubMedCrossRefGoogle Scholar
  15. 15.
    Hajjar RJ, Schmidt U, Matsui T, Guerrero L, Lee K, Gwathmey JK, Dec G, Semigran M, Rosenzweig A (1998) Modulation of ventricular function through gene transfer in vivo. Proc Natl Acad Sci USA 95:5251–5256PubMedCrossRefGoogle Scholar
  16. 16.
    Hilleman MR, Werner JH (1954) Recovery of new agents from patients with acute respiratory illness. Proc Soc Exp Biol Med 85:183–188PubMedGoogle Scholar
  17. 17.
    Kass-Eisler A, Falck-Pedersen E, Alvira M, Rivera J, Buttrick PM, Wittenberg BA, Cipriani L, Leinwand LA (1993) Quantitative determination of adenovirusmediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci USA 90:11498–11502PubMedCrossRefGoogle Scholar
  18. 18.
    Kirshenbaum LA, MacLellan WR, Mazur W, French BA, Schneider MD (1993) Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus. J Clin Invest 92:381–387PubMedCrossRefGoogle Scholar
  19. 19.
    Kruijer W, van Schaik FM, Sussenbach JS (1980) Nucleotide sequence analysis of a region of adenovirus 5 DNA encoding a hitherto unidentified gene. Nucleic Acids Res 8:6033–6042PubMedCrossRefGoogle Scholar
  20. 20.
    Lamping KG, Rios CD, Chun JA, Ooboshi H, Davidson BL, Heistad DD (1997) Intrapericardial administration of adenovirus for gene transfer. Am J Physiol 272:H310–H317PubMedGoogle Scholar
  21. 21.
    Lee J, Laks H, Drinkwater DC, Blitz A, Lam L, Shiraishi Y, Chang P, Drake TA, Ardehali A (1996) Cardiac and pulmonary replacement: cardiac gene transfer by intracoronary infusion of adenovirus vector-mediated reporter gene in the transplanted mouse heart. J Thorac Cardiovasc Surg 111:246–252PubMedCrossRefGoogle Scholar
  22. 22.
    Marcus ML (1983) The coronary circulation in health and disease. McGraw-Hill, New YorkGoogle Scholar
  23. 23.
    Muhlhauser J, Jones M, Yamada I, Cirielli C, Lemarchand P, Gloe TR, Bewig B, Signoretti S, Crystal RG, Capogrossi MC (1996) Safety and efficacy of in vivo gene transfer into the porcine heart with replication-deficient, recombinant adenovirus vectors. Gene Therapy 3:145–153PubMedGoogle Scholar
  24. 24.
    Mullins RJ, Malias MA, Hudgens RW (1989) Isoproterenol inhibits the increase in microvascular membrane permeability produced by bradykinin. J Trauma 29:1053–1063PubMedCrossRefGoogle Scholar
  25. 25.
    Nermut MV (1975) Fine structure of adenovirus Type 5: I. Virus capsid. Virology 65:480–495PubMedCrossRefGoogle Scholar
  26. 26.
    Persson R, Svensson U, Everitt E (1983) Virus receptor interaction in the adenovirus system: II. Capping and cooperative binding of virions on HeLa cells. J Virol 46:956–963PubMedGoogle Scholar
  27. 27.
    Philipson L (1967) Attachment and eclipse of adenovirus. J Virol 1:868–875PubMedGoogle Scholar
  28. 28.
    Philipson L, Lonberg-Holm K, Pettersson U (1968) Virus-receptor interaction in an adenovirus system. J Virol 2:1064–1075PubMedGoogle Scholar
  29. 29.
    Rowe WP, Huebner RJ, Gilmore LK, Parrott RH, Ward TG (1953) Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc Soc Exp Biol Med 84:570–573PubMedGoogle Scholar
  30. 30.
    Shenk T (1996) Adenoviridae: the viruses and their replication. In: Fields BN, Knipe DM, Howley PM (eds) Fields virology. Lippincott-Raven, Philadelphia, pp 2111–2148Google Scholar
  31. 31.
    Trentin JJ, Yabe Y, Taylor G (1962) The quest for human cancer viruses. Science 137:835–849PubMedCrossRefGoogle Scholar
  32. 32.
    van Ormondt H, Maat J, van Beveren CP (1980) The nucleotide sequence of the transforming early region El of adenovirus type 5 DNA. Gene 11:299–309PubMedCrossRefGoogle Scholar
  33. 33.
    Weeks DL, Jones NC (1983) ElA control of gene expression is mediated by sequences 5’ to the transcriptional starts of the early viral genes. Mol Cell Biol 3:1222–1234PubMedGoogle Scholar
  34. 34.
    Wickham TJ, Mathias P, Cheresh DA, Nemerow GR (1993) Integrins α v β 3 and α v β 5 promote adenovirus internalization but not virus attachment. Cell 73:309–319PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • J. K. Donahue
    • 1
  1. 1.Institute of Molecular Cardiobiology, Department of MedicineJohns Hopkins University School of MedicineBaltimoreUSA

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