Functional Subsets of Memory T Cells Identified by CCR7 Expression

  • F. Sallusto
  • A. Langenkamp
  • J. Geginat
  • A. Lanzavecchia
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 251)

Abstract

When naive T cells home to lymph nodes, they first roll along high endothelial venules using CD62L, allowing the chemokine receptor CCR7 to engage its ligand, SLC, displayed by endothelial cells. The CCR7-SLC interaction activates integrins that promote firm adhesion and transmigration of the T cells into the lymph node (Butcher and Picker, 1996; Cyster, 1999).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • F. Sallusto
    • 1
  • A. Langenkamp
    • 1
  • J. Geginat
    • 2
  • A. Lanzavecchia
    • 2
  1. 1.Basel Institute for ImmunologyBaselSwitzerland
  2. 2.Institute of Research in BiomedicineBellinzonaSwitzerland

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