Extragenitale Manifestationen der HPV-Infektion

  • A. Rübben
Conference paper

Zusammenfassung

Die humanpathogenen Papillomviren weisen eine außerordentliche Typenvielfalt auf. Derzeit sind mehr als 80 verschiedene HPV-Genotypen bekannt (DELI-US et al. 1998). Die humanpathogenen Papillomviren sind streng epitheliotrop. Sie können als primäre Zielzellen die verhornenden Plattenepithelien der äußeren Haut, die anogenitale Übergangshaut sowie die nichtverhornenden Plattenepithelien der genitalen und oralen Schleimhäute infizieren. Je nach Präferenz werden die verschiedenen humanpathogenen Papil-lomvirus-Typen entsprechend als kutaneotrope oder als mucosotrope HPV bezeichnet (Tabelle 1). Etwa die Hälfte aller bekannten HPV-Typen induzieren benigne Haut- und Schleimhautwarzen, die nur sehr selten maligne entarten. Zu den hochmalignen (high risk) HPV zählen hingegen jene humanpathogene Papillomviren, die sich regelmäßig in den Plattenepithelkarzinomen der Haut von Patienten mit Epidermodysplasia verruciformis (Orth et al. 1978), im genitalen Morbus Bowen (Ikenberg et al. 1983) und in Zervix-karzinomen nachweisen lassen (Dürst et al. 1983).

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© Springer-Verlag Berlin Heidelberg 2000

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  • A. Rübben

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