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Role of P1 Receptors in Inflammation

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Purinergic and Pyrimidinergic Signalling II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 151 / 2))

The first demonstration that adenosine had anti-inflammatory properties was made in 1983 ({scC{upronstein}} et al. 1983) and the purine was subsequently shown to mediate its anti-inflammatory effects via specific cell surface receptors ({scC{upronstein}} et al. 1985; {sc{upRoberts} et al. 1985). Since 1983 it has also been known that locally released adenosine may act as an endogenous anti-inflammatory mediator ({sc{upCronstein}} et al. 1983) and it was subsequently demonstrated that promotion of endogenous adenosine release may mediate the anti-inflammatory effects of several potent agents currently in use for the treatment of inflammatory diseases like rheumatoid arthritis (RA).

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Authors and Affiliations

  1. Department of Medicine/Division of Rheumatology, New York University Medical Center, 550 First Ave, New York, NY, 10016, USA

    M.C. Montesinos & B.N. Cronstein

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  1. M.C. Montesinos
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  2. B.N. Cronstein
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Editors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133, Milan, Italy

    Maria Pia Abbracchio

  2. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Searle 8-477 (S-215) 303 East Chicago Avenue, Chicago, IL, 60611

    Michael Williams

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Montesinos, M., Cronstein, B. (2001). Role of P1 Receptors in Inflammation. In: Abbracchio, M.P., Williams, M. (eds) Purinergic and Pyrimidinergic Signalling II. Handbook of Experimental Pharmacology, vol 151 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56921-0_9

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  • DOI: https://doi.org/10.1007/978-3-642-56921-0_9

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