Analgetika Antinozizeptiva Adjuvanzien pp 682-683 | Cite as
TNF-Rezeptor (p75)-lgG1-Fusionsprotein (TNFR:Fc), Etanercept
Chapter
Zusammenfassung
Molekularbiologische/gentechnische Herstellung eines Fusionsproteins aus 2 humanen TNF-Rezeptorteilen des p75-Typs (Aminosäuresequenz 1–235: extrazellulärer Rezeptoranteil) mit einem 232 Aminosäuren langen humanen Fc-Teil des IgG1 in transfizierten CHO-Zellen: humanes Fusionsprotein mit einem Molekulargewicht (MG) von ca. 100.000.
Literatur
- Baumgartner S, Moreland LW, Schiff MH et al. (1996) Double-blind, placebo-controlled trial of tumor necrosis factor receptor (p8o) fusion protein (TNFR:Fc) in active rheumatoid arthritis (abstr.). Arthritis Rheum 39 (S): S74Google Scholar
- Franklin CM (1999) Clinical experience with soluble TNF P75 receptor in rheumatoid arthritis. Semin Arthritis Rheum 29/3: 172–181CrossRefPubMedGoogle Scholar
- Korth-Bradley JM, Rubin AS, Hanna RK et al. (2000) The pharmacokinetics of etanercept in healthy volunteers. Ann Pharmaco-ther 34/2: 161–164CrossRefGoogle Scholar
- Lovell DJ, Giannini EH, Reiff A et al. (2000) Etanercept in children with polyarticular juvenile rheumatoid arthritis. N Engl J Med 342/11: 763–769CrossRefPubMedGoogle Scholar
- Lipsky P, St. Clair W, Kavanaugh A et al. (1998) Long-term control of signs and symptoms of rheumatoid arthritis with chimeric monoclonal anti-TNFa antibody (Infliximab) in patients with active disease on methothrexate. ACR Abstract N° 1988Google Scholar
- Moreland LW (1998) A novel tumor necrosis factor antagonist improves the inflammatory symptoms of active and refractory rheumatoid arthritis. Clin Exp Rheumatol 16(4): 394Google Scholar
- Moreland LW, Baumgartner SW, Schiff MH et al. (1997) Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein N Engl J Med 337/3: 141–147CrossRefPubMedGoogle Scholar
- Moreland LW, Margolies G, Heck LW et al. (1996) Recombinant Soluble Tumor Necrosis Factor Receptor (p8o) Fusion Protein: Toxicity an Dose Finding Trial in Refractory Rheumatoid Arthritis J Rheum 23: 1849–1855PubMedGoogle Scholar
- Murray KM, Dahl SL (1997) Recombinant human tumor necrosis factor receptor (p75) Fc fusion protein (TNFR:Fc) in rheumatoid arthritis. Ann Pharmacother 11: 1335–1338Google Scholar
- Smith CA, Davis T, Anderson D et al. (1990) A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science 248: 1019–1023CrossRefPubMedGoogle Scholar
- Weinblatt ME, Kremer JM, Bankhurst AD et al. (1999) A trial of etanercept, a recombinant tumor necrosis factor receptor: fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 340/4: 253–259CrossRefPubMedGoogle Scholar
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