Abstract
Phytoestrogens are compounds that are naturally present in almost all plant foods to a varying degree. They include several different classes of chemical compounds known as isoflavones, coumestans and lignans (Fig. 1). These compounds are structurally similar to the human hormone oestradiol, which is the most potent form of oestrogen [1]. Oestrogen is known to be ofkey importance in the maintenance of female reproductive health and bone density and is also believed to have a cardioprotective effect in pre-menopausal women. For these reasons, phytoestrogens are being viewed as potentially important in the development and management of a range of human diseases, including heart disease and some forms of hormone-sensitive cancers.
Keywords
Soya Bean Menopausal Symptom Soya Milk Soya Food Isoflavone IntakePreview
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References
- 1.Kurzer MS, Xu X. Dietary phytoestrogens. Annual Review of Nutrition 1997; 17: 353–381CrossRefGoogle Scholar
- 2.Setchell KD, Borriello SP, Hulme P, Kirk DN, Axelson M. Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease. American Journal of Clinical Nutrition 1984; 40: 569–578Google Scholar
- 3.Anderson JJB, Anthony M, Messina M, Garner Sc. Effects of phyto-oestrogens on tissues. Nutrition Research Reviews 1999; 12: 75–116CrossRefGoogle Scholar
- 4.Bingham SA, Atkinson C, Liggins J, Bluck L, Coward A. Phyto-oestrogens: where are we now? British Journal of Nutrition 1998; 79: 393–406CrossRefGoogle Scholar
- 5.Thorogood M, Mann J, Appleby P, McPherson K. Risk of death from cancer and ischaemic heart disease in meat and non-meat eaters BMJ 1994; 308: 1667–1670CrossRefGoogle Scholar
- 6.Setchell KD, Cassidy A. Dietary isoflavones: biological effects and relevance to human health. Journal of Nutrition 1999; 129: 758S–767SGoogle Scholar
- 7.Reinli K, Block G. Phytoestrogen conte nt of foods-a compendium ofliterature values. Nutrition & Cancer 1996; 26: 123–148CrossRefGoogle Scholar
- 8.Crouse JR, III, Morgan T, Terry JG, Ellis J, Vitolins M, Burke GL. A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Archives of Internal Medicine 1999; 159: 2070–2076CrossRefGoogle Scholar
- 9.Adlercreutz H, Fotsis T, Lampe J et al. Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chromatography-mass spectrometry. Scandinavian Journal of Clinical Laboratory Investigations 1993; 215: 5–18CrossRefGoogle Scholar
- 10.Adlercreutz H, Fotsis T, Watanabe S et al. Determination of lignans and isoflavonoids in plasma by isotope dilution gas chromatography-mass spectrometry. Cancer Detection and Prevention 1994; 18: 259–271Google Scholar
- 11.Cassidy A, Bingham S, Setchell K. Biological effects of isoflavones in young women: importance of the chemical composition of soyabean products. British Journal of Nutrition 1995; 74: 587–601CrossRefGoogle Scholar
- 12.de Kleijn MJJ, van der SchouwYT, Wilson PWF, Grobbee DE, Jacques PE Intake of dietary phytoestrogens in postmenopausal women. The Framingham Heart Study. Third International Symposium on the role of soy in preventing and treating chronic disease 1999. Washington, USA. 1999Google Scholar
- 13.Golden RJ, Noller KL, Titus-Ernstoff L et al. Environmental endocrine modulators and human health: an assessment of the biological evidence. Critical Reviews in Toxicology 1998; 28: 109–227CrossRefGoogle Scholar
- 14.Setchell KD, Zimmer-Nechemias L, Cai J, Heubi JE. Isofiavone content of infant formulas and the metabolic fate of these phytoestrogens in early life. [86 refs]. American Journal of Clinical Nutrition 1998; 68: 1453S–1461SGoogle Scholar
- 15.MAFF Joint Food Safety and Standards Group. Plant oestrogens in soya-based infant formulae. Food Surveillance Information Sheet No. 167. 1998Google Scholar
- 16.National Dairy Council. Advice about soya-based infant formulae. Issue 1, 1999/2000. 1999. National Dairy Council Nutrition Service. 1999Google Scholar
- 17.Anderson JW, Iohnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy pro tein intake on serum lipids. New England Journal of Medicine 1995; 333: 276–282CrossRefGoogle Scholar
- 18.Anthony MS, Clarkson TB, Hughes CLJ, Morgan TM, Burke GL. Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys. Journal of Nutrition 1996; 126: 43–50Google Scholar
- 19.Greaves KA, Zhang L, Williams K, Parks J, and Wagner JD. Phytoestrogen and intact soy protein administrations differ in their effects on plasma lipids and lipoproteins. Symposium on Phytoestrogen Research Methods, Tuscon, Arizona. 1997Google Scholar
- 20.Nestei PJ, Yamashita T, Sasahara T et al. Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arteriosclerosis Thrombosis & Vascular Biology 1997; 17: 3392–3398CrossRefGoogle Scholar
- 21.St Clair RW. Estrogens and atherosclerosis: phytoestrogens and selective estrogen receptor modulators. Current Opinion In Lipidology 1998; 9: 457–463CrossRefGoogle Scholar
- 22.Kapiotis S, Hermann M, Held J, Seelos C, Ehringer H, Gmeiner BM. Genistein, the dietaryderived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL. Arteriosclerosis, Thrombosis & Vascular Biology 1997; 17: 2868–2874CrossRefGoogle Scholar
- 23.Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases. Annals of Medicine 1997; 29: 95–120Google Scholar
- 24.Adlercreutz H, Mousavi Y, Clark J et al. Dietary phytoestrogens and cancer: in vitro and in vivo studies. Journal of Steroid Biochemistry and Molecular Biology 1992; 41: 331–337CrossRefGoogle Scholar
- 25.Horn-Ross PL. Phytoestrogens, body composition, and breast cancer. Cancer Causes & Control 1995; 6: 567–573CrossRefGoogle Scholar
- 26.Trock B, White Butler L, Clarke R, and Hilakivi-Clarke L. Meta-analys is of soy intake and breast cancer. Third International Symposium on the role of soy in preventing and treating chronic disease. Washington, DC, USA. 1999Google Scholar
- 27.Mydlo JH, Kanter JL, Kral JG, MacChia RJ. The role of obesity and diet in urological carcinogenesis. British Journal of Urology International 1999; 84: 225–234CrossRefGoogle Scholar
- 28.Barken I, Eliaz I, Baranov IE, and Geiler J. The effect of two soy preparations on prostatespecific antigen levels in patients with prostate cancer and the correlation of prostatespecific antigen changes with plasma genistein. Third International Symposium on the role of soy in preventing and treating chronic disease. 1999. Washington, DC, USAGoogle Scholar
- 29.Morton MS, Matos-Ferreira A, Abranches-Monteiro L et al. Measurement and met abolism of isoflavonoids and lignans in the human male. Cancer Letters 1997; 114: 145–151CrossRefGoogle Scholar
- 30.Severson RK, Nomura AM, Grove JS, Stemmermann GN. A prospective study of dernographics, diet, and prostate cancer among men of Iapanese ancestry in Hawaii. Cancer Research 1989; 49: 1857–1860Google Scholar
- 31.Messina MJ, Persky V, Setchell KD, Barnes S. Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutrition & Cancer 1994; 21: 113–131CrossRefGoogle Scholar
- 32.Bingham SA, Setchell KD, Cassidy A. Soya and safety. New Scientist 1994; 46–47Google Scholar
- 33.Arjmandi BH, Alekel L, Hollis BW et al. Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. Journal of Nutrition 1996; 126: 161–167Google Scholar
- 34.Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF, Erdman JW Ir, Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. American Journal of Clinical Nutrition 1998; 68: 1375S–1379SGoogle Scholar
- 35.Kardinaal AF, Morton MS, Bruggemann-Rotgans IE, van Beresteijn EC. Phyto-oestrogen excretion and rate of bone loss in postmenopausal women. European Journal of Clinical Nutrition 1998; 52: 850–855CrossRefGoogle Scholar
- 36.Kao PC, P’eng FK. How to reduce the risk factors of osteoporosis in Asia. Chung Hua i Hsueh Tsa Chih-Chinese Medical Journal 1995; 55: 209–213Google Scholar
- 37.Ioffe H, Cohen LS. Estrogen, serotonin, and mood disturbance: where is the therapeutic bridge? Biological Psychiatry 1998; 44: 798–811CrossRefGoogle Scholar
- 38.Rubinow DR, Schmidt PJ, Roca CA. Estrogen-serotonin interactions: implications for affective regulation. Biological Psychiatry 1998; 44: 839–850CrossRefGoogle Scholar
- 39.Dye L, Blundell JE. Menstrual cyele and appetite control: implications for weight regulation. Human Reproduction 1997; 12: 1142–1151CrossRefGoogle Scholar
- 40.Lippert TH, Filshie M, Muck AO, Seeger H, Zwirner M. Serotonin metabolite excretion after postmenopausal estradiol therapy. Maturitas 1996; 24: 37–41CrossRefGoogle Scholar
- 41.Baird DD, Umbach DM, Lansdell L et al. Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. Journal of Clinical Endocrinology & Metabolism 1995; 80: 1685–1690CrossRefGoogle Scholar
- 42.Nagata C, Shimizu H, Takami R, Hayashi M, Takeda N, Yasudat K. Hot flushes and other menopausal symptoms in relat ion to soy product intake in Iapanese women. Climacteric 1999; 2: 6–12CrossRefGoogle Scholar
- 43.Murkies AL, Lombard C, Strauss BJG, Wilcox G, Burger HG, Morton MS. Dietary flour supplementation decreases post-menopausal hot flushes: Effect of soy and wheat. Maturitas 1995; 21: 189–195CrossRefGoogle Scholar
- 44.Brzezinski A, Adlercreutz H, Shaoul R, Shmueli A, Reosler A, Schenker JG. Short-term effects of phytoestrogen-rich diet on postmenopausal women. Menopause 1997; 4: 89–94CrossRefGoogle Scholar
- 45.Albertazzi P, Pansini F, Bottazzi M, Bonaccorsi G, De Aloysio D, Morton MS. Dietary soy supplementation and phytoestrogen levels. Obstetrics & Gynecology 1999; 94: 229–231CrossRefGoogle Scholar
- 46.Gamache PH, Acworth IN. Analysis of phytoestrogens and polyphenols in plasma, tissue, and urine using HPLC with coulometric array detection. Proceedings of the Society for Experimental Biology & Medicine 1998; 217: 274–280Google Scholar
- 47.Wiseman H. Dietary phytoestrogens: disease prevention versus potential hazards. Nutrition and Food Science 1997; 1: 32–38Google Scholar
- 48.Santti R, Makela S, Strauss L, Korkman J, Kostian ML. Phytoestrogens: potential endocrine disruptors in males. Toxicology & Industrial Health 1998; 14: 223–237Google Scholar
- 49.World Health Organisation. Diet, nutrition and the prevention of chronic disease. 1990. Geneva, WHO. Technical Report Series no. 797Google Scholar