Single Molecule Detection Using Near Infrared Surface-Enhanced Raman Scattering

  • K. Kneipp
  • H. Kneipp
  • I. Itzkan
  • R. R. Dasari
  • M. S. Feld
Chapter
Part of the Springer Series in Chemical Physics book series (CHEMICAL, volume 67)

Abstract

Detecting single molecules and simultaneously identifying their chemical structures represents the ultimate limit in chemical analysis, and is of great practical interest in many fields. For instance, further progress in human DNA sequence studies will mainly depend on developing methods for selective and rapid detection of the four single DNA bases [1]. Monitoring molecules and molecular interactions at the single molecule level in cells or biological membranes and identifying single DNA fragments would be of great interest in the fields of biology, medicine, and pharmacology. Up to now, optical trace detection with single-molecule sensitivity has been mainly based on laser-induced fluorescence [2, 3, 4, 5]. Effective fluorescence cross sections can reach about 10-16 cm2 per molecule for high-quantum yield fluorophores. The fluorescence method provides ultrahigh sensitivity but, particularly at room temperature, the amount of molecular information which can be obtained is limited.

Keywords

Gold Cluster SERS Spectrum Colloidal Silver SERS Enhancement Single Molecule Detection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    R. Keller et al., Los Alamos Annual Report (1990)Google Scholar
  2. 2.
    R. Keller, W. P. Ambrose, R M. Goodwin, J. H. Jett, J. C. Martin, and M. Wu, Appl. Spectr. 50, 12A (1996)ADSCrossRefGoogle Scholar
  3. 3.
    R. Rigler, J. Widengren, and Ü. Mets, Fluorescence Spectroscopy, O. S. Wolfbeis (ed.), p. 13 (Springer-Verlag, Berlin, 1992)Google Scholar
  4. 4.
    S. Nie and R. N. Zare, Ann. Rev. Biophys. Biomol. Struct. 26, 567 (1997)CrossRefGoogle Scholar
  5. 5.
    X. S. Xie and J. K. Trautman, Ann. Rev. Phys. Chem. 49, 441 (1998)ADSCrossRefGoogle Scholar
  6. 6.
    D. L. Jeanmaire and R. P. V. Duyne, J. Electroanal. Chem. 84, 1 (1977)CrossRefGoogle Scholar
  7. 7.
    M. G. Albrecht and J. A. Creighton, J. Am. Chem. Soc. 99, 5215 (1977)CrossRefGoogle Scholar
  8. 8.
    A. Otto, in Light Scattering in Solids IV. Electronic Scattering, Spin Effects, SERS and Morphic Effects, M. Cardona and G. Guntherodt (eds.), vol. 1984, p. 289 (Springer-Verlag, Berlin, 1984)Google Scholar
  9. 9.
    M. Moskovits, Rev. Mod. Phys. 57, 783 (1985)ADSCrossRefGoogle Scholar
  10. 10.
    K. Kneipp, Y. Wang, H. Kneipp, I. Itzkan, R. R. Dasari, and M. S. Feld, Phys. Rev. Lett. 76, 2444 (1996)ADSCrossRefGoogle Scholar
  11. 11.
    K. Kneipp, Y. Wang, H. Kneipp, L. T. Perelman, I. Itzkan, R. R. Dasari, and M. S. Feld, Phys. Rev. Lett. 78, 1667 (1997)ADSCrossRefGoogle Scholar
  12. 12.
    S. Nie and S. R. Emory, Science 275, 1102 (1997)CrossRefGoogle Scholar
  13. 13.
    K. Kneipp, H. Kneipp, I. Itzkan, R. R. Dasari, and M. S. Feld, Chem. Rev. 99, 2957 (1999)CrossRefGoogle Scholar
  14. 14.
    K. Kneipp, H. Kneipp, I. Itzkan, R. R. Dasari, and M. S. Feld, Current Science 77, 915 (1999)Google Scholar
  15. 15.
    K. Kneipp, H. Kneipp, I. Itzkan, R. R. Dasari, and M. S. Feld, Chem. Phys. 247, 155 (1999)ADSCrossRefGoogle Scholar
  16. 16.
    A. Otto, I. Mrozek, H. Grabhorn, and W. J. Akemann, J. Phys. Chem. Condens. Matter 4, 1143 (1992)ADSCrossRefGoogle Scholar
  17. 17.
    A. Otto, in Int. Conference on Raman Spectroscopy XVI, Kapstadt, South Africa, 1998Google Scholar
  18. 18.
    A. Campion, Chem. Soc. Rev. 4, 241 (1998)CrossRefGoogle Scholar
  19. 19.
    M. Kerker, O. Siiman, L. A. Bumm, and D. S. Wang, Applied Optics 19, 3253 (1980)ADSCrossRefGoogle Scholar
  20. 20.
    D. S. Wang and M. Kerker, Phys. Rev. B 24, 1777 (1981)ADSCrossRefGoogle Scholar
  21. 21.
    E. J. Zeman and G. C. Schatz, J. Phys. Chem. 91, 634 (1987)CrossRefGoogle Scholar
  22. 22.
    D. A. Weitz and M. Oliveria, Phys. Rev. Lett. 52, 1433 (1984)ADSCrossRefGoogle Scholar
  23. 23.
    K. Kneipp, H. Kneipp, V. B. Kartha, R. Manoharan, G. Deinum, I. Itzkan, R. R. Dasari, and M. S. Feld, Phys. Rev. E 57, R6281 (1998)ADSCrossRefGoogle Scholar
  24. 24.
    K. Kneipp, H. Kneipp, R. Manoharan, E. B. Hanlon, I. Itzkan, R. R. Dasari, and M. S. Feld, Appl. Spectrosc. 52, 1493 (1998)ADSCrossRefGoogle Scholar
  25. 25.
    Y. Yamaguchi, M. K. Weldon, and M. D. Morris, Appl. Spectrosc. 53, 127 (1999)ADSCrossRefGoogle Scholar
  26. 26.
    V. M. Shalaev, Nonlinear Optics of Random Media (Springer-Verlag, Berlin, Heidelberg, 2000)Google Scholar
  27. 27.
    E. Y. Poliakov, V. M. Shalaev, V. A. Markel, and R. Botet, Opt. Lett. 21, 1628 (1996)ADSCrossRefGoogle Scholar
  28. 28.
    E. Y. Poliakov, V. A. Markel, V. M. Shalaev, and R. Botet, Phys. Rev. B 57, 14901 (1998)ADSCrossRefGoogle Scholar
  29. 29.
    V. M. Shalaev and A. K. Sarychev, Phys. Rev. B 57, 13265 (1998)ADSCrossRefGoogle Scholar
  30. 30.
    P. Gadenne, E. Brouers, V. M. Shalaev, and A. K. Sarychev, J. Opt. Soc. Am. B 15, 68 (1998)ADSCrossRefGoogle Scholar
  31. 31.
    D. P. Tsai, J. Kovacs, Z. Wang, M. Moskovits, V. M. Shalaev, J. S. Suh, and R. Botet, Phys. Rev. Lett. 72, 4149 (1994)ADSCrossRefGoogle Scholar
  32. 32.
    P. Zhang, T. L. Haslett, C. Douketis, and M. Moskovits, Phys. Rev. B 57, 15513 (1998)ADSCrossRefGoogle Scholar
  33. 33.
    V. A. Markel, V. M. Shalaev, P. Zhang, W. Huynh, L. Tay, T. L. Haslett, and M. Moskovits, Phys. Rev. B 59, 10903 (1999)ADSCrossRefGoogle Scholar
  34. 34.
    K. Kneipp, Y. Wang, R. R. Dasari, and M. S. Feld, Appl. Spectr. 49, 780 (1995)ADSCrossRefGoogle Scholar
  35. 35.
    H. Kneipp, K. Kneipp, and F. Seifert, Chem. Phys. Lett. 212, 374 (1993)ADSCrossRefGoogle Scholar
  36. 36.
    K. Kneipp, H. Kneipp, G. Deinum, I. Itzkan, R. R. Dasari, and M. S. Feld, Appl. Spectr. 52, 175 (1998)ADSCrossRefGoogle Scholar
  37. 37.
    K. Kneipp, H. Kneipp, R. Manoharan, I. Itzkan, R. R. Dasari, and M. S. Feld, Bioimaging 6, 104 (1998)CrossRefGoogle Scholar
  38. 38.
    M. I. Stockman, V. M. Shalaev, M. Moskovits, R. Botet, and T. F. George, Phys. Rev. B 46, 2821 (1992)ADSCrossRefGoogle Scholar
  39. 39.
    R. Sheng, F. Nii, and T. M. Cotton, Anal. Chem. 63, 437 (1991)CrossRefGoogle Scholar
  40. 40.
    J. Thornton and R. K. Force, Appl. Spectrosc. 45, 1522 (1991)ADSCrossRefGoogle Scholar
  41. 41.
    H. Xu, E. J. Bjerneld, M. Kåll, and L. Borjesson, Phys. Ref. Lett.83, 4357 (1999)Google Scholar
  42. 42.
    K. Kneipp, Exp. Tech. Phys. 36, 161 (1988)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • K. Kneipp
  • H. Kneipp
  • I. Itzkan
  • R. R. Dasari
  • M. S. Feld

There are no affiliations available

Personalised recommendations