Perinatal Imaging pp 13-23 | Cite as
Abnormal Fetal Growth
Abstract
Fetal growth restriction (FGR) is an important cause of increased morbidity and mortality during the perinatal period (e.g., stillbirth, prematurity, asphyxia and neonatal complication) and in childhood (e.g., growth failure, neurological impairment and behavioral disorders) (Schauseil-Zipf et al. 1989, Allen 1984, Wienerroither et al. 2001). Furthermore, during recent years, several large-scale epidemiological studies in England and in Sweden have tended to suggest a relation between low birth weight and several discases in adulthood (so-called Barker’s theory) (Barker et al. 1990, Williams et al. 1992, Baker et al. 1993). In studies exploring these associations, the trends in coronary heart disease, hypertension and non-insulin-dependent diabetes mellitus were significantly higher in low-birth-weight infants. To date, the most widely accepted explanation of this would be an adaptation of the fetus to a limited supply of nutrients. In doing so, the fetus would permanently change its physiology and metabolism and accelerate its postnatal growth as a result of good living conditions, but this may lead to excessive demand on limited cell mass (Eriksson 2000).
Keywords
Obstet Gynecol Fetal Growth Uterine Artery Umbilical Artery Fetal Growth RestrictionPreview
Unable to display preview. Download preview PDF.
References
- Abramowicz JS, Sherer DM, Bar-Tov E, Woods JR (1991) The cheek-to-cheek diameter in the ultrasonographic assessment of fetal growth. Am J Obstet Gynecol 165:846–852PubMedCrossRefGoogle Scholar
- Acker DB, Gregory KD, Sachs BP, Friedman ED (1988) Risk factors for shoulder dystocia. Obstet Gynecol 66:762–768Google Scholar
- Alfirevic A, Neilson JP (1995) Doppler ultrasonography in high-risk pregnancies: systematic review with meta-analysis. Am J Obstet Gynecol 172:1379–1387PubMedCrossRefGoogle Scholar
- Allen MC (1984) Developmental outcome and follow-up of the small for gestational age infant. Semin Perinatol 8:123–156PubMedGoogle Scholar
- ACOG (2001) American College of Obstetricians and Gynecologists issues guidelines on fetal macrosomia. Am Farn Physician 64: 169–170Google Scholar
- Arduini A, Rizzo G (1991) Fetal renal artery velo city waveforms and amniotic fluid volume in growth retarded and post-term fetuses. Obstet Gynecol 77:370–373PubMedGoogle Scholar
- Arias F (1994) Accuracy of the middle cerebral-to-umbilical artery resistance index ratio in the prediction of neonatal outcome in patients at high risk for fetal and neonatal complication. Am J Obstet Gynecol 171:1541–1545PubMedCrossRefGoogle Scholar
- Baker DJP, Gluckman PO, Godfrey KM, et al (1993) Fetal nutrition and cardiovascular disease in adult life. Lancet 341:938–941CrossRefGoogle Scholar
- Baker P, Lever P, Gorton E (1992) An increasing incidence of fetal macrosomia. J Obstet Gynecol 12:281CrossRefGoogle Scholar
- Baker PN, Johnson IR, Gowland PA, Hykin I, Adams V, Mansfield P, et al (1995) Measurement of fetal liver, brain and placental volumes with echo-planar magnetic resonance imaging. Br J Obstet Gynecol 102:35–39CrossRefGoogle Scholar
- Barker DJP, Bull AR, Osmond C, Simmonds SJ (1990) Fetal and placental size and risk of hypertension in adult life. BMJ 301:259–262PubMedCrossRefGoogle Scholar
- Baschat AA, Weiner CP (2000) Umbilical artery Doppler screening for detection of the small fetus in need of anteparturn surveillance. Am J Obstet Gynecol 182:154–158PubMedCrossRefGoogle Scholar
- Baschat AA, Gembruch U, Weiner CP, et al (2001) In severe growth restriction (IUGR), Doppler deteriorates before biophysical parameters worsen (abstract). Am J Obstet Gynecol 184:102Google Scholar
- Bewley S, Cooper D, Campbell S (1991) Doppler investigation of uteroplacental blood flow resistance in the second trimester: a screening study for pre-eclampsia and intrauterine growth retardation. Br J Obstet Gynaecol 98:871–879PubMedCrossRefGoogle Scholar
- Blackwell SC, Moldenhauer J, Redman M, Hassan SS, Wolfe M, Berry L (2001) Relationship between sonographic pattern of intrauterine growth restriction and acid-base status at the time of cordocentesis. Arch Gynecol Obstet 264:191–193PubMedCrossRefGoogle Scholar
- Bracero LA, Baxi LV, Rey HR, et al (1985) Use of ultrasound in antenatal diagnosis of large for gestational age infants in diabetic gravid patients. Am J Obstet Gynecol 152:43–47PubMedGoogle Scholar
- Brantberg A, Schwarzler P, Alcais A, et al (1999) Central arterial hemodynamics in small-for gestational-age fetuses before and during maternal hyperoxygenation: a Doppler velocimetrie study with partieular attention to the aortie isthmus. Ultrasound Obstet Gynecol 14:237–243PubMedCrossRefGoogle Scholar
- Brown HL, Miller JM, Gabert HA, et al (1987) Ultrasonic reeognition of the small-for gestational-age fetus. Obstet Gynecol 69:631–635PubMedGoogle Scholar
- Campbell S, Diaz-Raeasens I, Griffin D, Cohen-Overbeek RE, Pearee JM, Wilson K (1983) New Doppler teehnique for assessing uteroplacental blood flow. Laneet 1: 675–679Google Scholar
- Catalano PM, Tyzbir ED, Allen SR, Meßcan JH, McAuliffe TL (1992) Evaluation of fetal growth by estimation of neonatal body composition. Obstet Gynecol 79:46–50PubMedGoogle Scholar
- Chang FM, Hsu K, Ko H, et al. (1997) 3D US assessment of fetalliver volume in normal pregnaneies. Ultrasound Med Biol 23:381–389PubMedCrossRefGoogle Scholar
- Chauhan SP, Lutton PM, Bailey KJ, Guerrieri JP, Morrison JP (1992) Intraparturn clinical, sonographic, and parous patient’ estimates of newborn birth weight. Obstet Gynecol 79:956–958PubMedGoogle Scholar
- Chauhan SP, West DJ, Seardo JA, Boyd JM, Joiner J, Hendrix NW (2000) Antepartum detection of maerosomie fetus: clinical versus sonographic, including soft-tissue measurements. Obstet Gynecol 95:639–642PubMedCrossRefGoogle Scholar
- Chevernak JL, Divon MY, Hirsch J, et al (1989) Macrosomia in postdate pregnancy: Is routine sonographic screening indieated? Am J Obstet Gynecol 161:753CrossRefGoogle Scholar
- Craigo SD, Beaeh ML, Harvey-Wilkes KB, D’Alton ME (1996) Ultrasound predictors of neonatal outcome in intrauterine growth restriction. Am J Perinatol 13:465–471PubMedCrossRefGoogle Scholar
- Dashe JS, McIntire DD, Lueas MI, Leveno KJ (2000) Effects of symmetric and asymmetric fetal growth on pregnancy outcomes. Obstet Gynecol 96:321–327PubMedCrossRefGoogle Scholar
- Degani S (2001) Fetal biometry: clinical, pathological and teehnieal eonsiderations. Obstet Gynecol Surv 56:159–167PubMedCrossRefGoogle Scholar
- Divon M, Ferber A (2001) Umbilieal artery Doppler velocimetry: an update. Semin Perinatol 25:44–47PubMedCrossRefGoogle Scholar
- Dudley NJ (1995) Selection of appropriate ultrasound methods for the estimation offetal weight. Br J Radiol 68:385–388PubMedCrossRefGoogle Scholar
- Eriksson J, Forsen T, Tuomilehto J, Osmond C, Barker D (2000) Fetal and childhood growth and hypertension in adult life. Hypertension 36:790–794PubMedCrossRefGoogle Scholar
- Fouron JC, Gosselin J, Amiel-Tison C, Infante-Rivard C, Fouron C, Skoll A, Veilleux A (2001) Correlation between prenatal velocity waveforms in the aortic isthmus and neurodevelopmental outcome between the ages of 2 and 4 years. Am J Obstet Gynecol 184:630–636PubMedCrossRefGoogle Scholar
- Gardeil F, Greene R, Stuart B, Turner MJ (1999) Subeutaneous fat in fetal abdomen as apredictor of growth restriction. Obstet Gynecol 94:209–212PubMedCrossRefGoogle Scholar
- Gilby JR, Williams MC, Spellaey WN (2000) Fetal abdominal cireumferenee measurements of 35 and 38 cm as predictors of macrosomia: a risk factor for shoulder dystocia. J Reprod Med 45:936–938PubMedGoogle Scholar
- Goffinet F, Paris-Llado J, Nisand I, et al (1997) Umbilical artery Doppler veloeimetry in unselected and low risk pregnaneies: a review of randomized controlled trials. Br J Obstet Gynaecol 104:425–430PubMedCrossRefGoogle Scholar
- Goffinet F, Aboulker D, Paris-Llado J, Bucourt M, Uzan M, Papiernik E, Bréart G (2001) Screening with a uterine doppler in low risk pregnant women followed by low dose aspirin in women with abnormal results: a multicenter randomised controlled trial. Br J Obstet Gynaecol 108: 510–518CrossRefGoogle Scholar
- Goldenberg RL, Cliver SP (1997) Small for gestational age and IUGR: definitions and standards. Clinic Obstet Gynecol 40:704–714CrossRefGoogle Scholar
- Goldenberg RL, Humphrey JL, Hale CB, et al (1983) Neonatal deaths in Alabama, 1970-1980: an analysis of birth weight and race-specific neonatal mortality rates. Am J Obstet Gynecol 145:545–555PubMedGoogle Scholar
- Goldenberg RL, Cutter GR, Hoffman HJ, et al (1989) IUGR: standards for diagnosis. Am J Obstet Gynecol 161:271–277PubMedCrossRefGoogle Scholar
- Golditch IM (1978) The large fetus: management and outcome. Obstet Gynecol 52:26–30PubMedGoogle Scholar
- Gosling RG, King DH (1975) Ultrasonic angiology. In: Harcus AW, Adamson L (eds) Arteries and veins. Edinburgh: Churchill-Livingstone, pp 61–98Google Scholar
- Gramellini D, Folli MC, Raboni S, et al (1992) Cerebral umbilical Doppler ratio as a predictor of adverse perinatal outcome. Obstet Gynecol 79:416–420PubMedCrossRefGoogle Scholar
- Grannum PA, Hobbins JC (1979) The ultrasound changes in the maturing placenta and their relationship to fetal pulmonic maturity. Am J Obstet Gynecol 133:915–922PubMedGoogle Scholar
- GRIT Study Group (1996) When do obstetricians recommend delivery for high-risk preterm growth-retarded fetus? Eur J Obstet Gynecol Reprod Biol 67:121–126CrossRefGoogle Scholar
- Guzman E, Vintzileos A, Martins M (1995) Relationship between middle eerebral artery velocimetry, computer fetal heart rate assessment and degree of academia at birth in intrauterine growth restricted fetuses. Am J Obstet Gynecol 172:337CrossRefGoogle Scholar
- Hadloek FP, Harrist RB, Fearneyhough TC, et al (1985a) Use of femur length/abdominal circumference ratio in detecting the macrosomic fetus. Radiology 154:503–505Google Scholar
- Hadlock FP, Harrist RB, Sharman RS, et al (1985b) Estimation of fetal weight with the use of head, body, and femur measurements: a prospective study. Am J Obstet Gynecol 151:333–337PubMedGoogle Scholar
- Harrington KF (2000) Making best and appropriate use of fetal biophysieal and Doppler ultrasound data in the management of the growth restricted fetus. Ultrasound Obstet Gynecol 16:399–401PubMedCrossRefGoogle Scholar
- Hili IM, Guzick D, Doyles D, et al (1992) Subcutaneous tissue thickness can not be used to distinguish abnormalities of fetal growth. Obstet Gynecol 80:268–271Google Scholar
- Horrigan TI (2001) Physicians who induce labor for fetal macrosomia do not reduce cesarcan delivery rates. J Perinatol 21:93–96PubMedCrossRefGoogle Scholar
- Irion O, Masse I, Forest JC, Moutquin JM (1998) Prediction of pre-eclampsia, low birthweight for gestation and prematurity by uterine artery velocity waveform analysis in low risk nulliparous women. Br J Obstet Gynaecol 105:422–429PubMedCrossRefGoogle Scholar
- Jacobson SL, Imhof R, Manning N, et al (1990) The value of Doppler assessment of the uteroplacental eirculation in predicting preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol 162:110–114PubMedCrossRefGoogle Scholar
- Johnstone FD, Prescott RJ, Steel JM, Mao JH, Chambers S, Muir N (1996) Clinical and ultrasound prediction of macrosomia in diabetics pregnancy. Br J Obstet Gynaecol 103:747–754PubMedCrossRefGoogle Scholar
- Kingdom J, Smith G (2000) Diagnosis and management of IUGR. In: Kingdom J, Baker P (eds) Intrauterine growth restriction. Springer, Berlin Heidelberg New York, pp 257–273Google Scholar
- Konje JC, Bell S, Taylor DJ (2001) Abnormal doppler veloeim etry and blood flow volume in the middle cerebral artery in severe intrauterine growth restriction: Is the occurrence of reversal of compensatory flow too late? Br J Obstet Gynaecol 108:973–979CrossRefGoogle Scholar
- Langer O (2000) Fetal macrosomia: etiologic factors. Clin Obstet Gynecol 43:283–297PubMedCrossRefGoogle Scholar
- Langer O, Berkus MD, Huff RW, Samueloff A (1991) Shoulder dystocia: should the fetus weighing greater than or equal to 4000 grams be delivered by cesarcan section? Am J Obstet Gynecol 165:831–837PubMedCrossRefGoogle Scholar
- Lin CC, Samboya-Forgas Z (1998) Current concepts of FGR. Obstet Gynecol 92:1044–1055PubMedCrossRefGoogle Scholar
- Lin CC, Sheikh Z, Lopata R (1990) The association between oligohydramnios and IUGR. Obstet Gynecol 76:1100–1104PubMedGoogle Scholar
- Lubchenco LO, Hansman C, Boyd E (1966) Intrauterine growth in length and head circumference as estimated from live births at gestational age from 26–42 weeks. Pediatrics 37:403PubMedGoogle Scholar
- Manning FA (1997) Fetal biophysical profile: a critical appraisal. Fetal Matern Med Rev 9:103–123CrossRefGoogle Scholar
- Manning FA, Platt LD, Sipos L (1980) Antepartum fetal evaluation: the development of fetal biophysical profile score. Am J Obstet Gynecol 136:187–195Google Scholar
- Mari G, Deter RL (1992a) Middle cerebral flow velocity waveform and fetal compromise. Am J Obstet Gynecol 168:1336CrossRefGoogle Scholar
- Mari G, Deter RL (1992b) Middle cerebral artery flow velocity waveforms in normal and small-for-gestational-age fetuses. Am J Obstet Gynecol 166:1262–1270PubMedCrossRefGoogle Scholar
- McCowan LM, Harding JE, Stewart EW (2000) Umbilical artery studies in small for gestational age babies reflect disease severity. Br J Obstet Gynecol 107:916–925CrossRefGoogle Scholar
- McCurdy CM, Seeds JW (1993) Oligohydramnios. Semin Perinatol 17:183–196PubMedGoogle Scholar
- Mintz MC, Landon MB, Gabbe SG, et al (1989) Shoulder soft tissue width as a predictor of macrosomia in diabetic pregnancies. Am J Perinatol 6:240PubMedCrossRefGoogle Scholar
- Mocanu E, Greene R, Byrne M, Turner M (2000) Obstetric and neonatal outcome of babies weighing more than 4.5 kg: an analysis by parity. Eur J Obstet Gynaecol 92:229–233CrossRefGoogle Scholar
- Mondalou HD, Dorchester WL, Thorosian A, et al (1980) Macrosomia: maternal, fetal, and neonatal complication. Obstet Gynecol 55:420Google Scholar
- Neilson JP, Alfirevic Z (1997) Doppler ultrasound in high risk pregnancies. Cochrane Library, issue 4Google Scholar
- O’Reilly-Green C, Divon M (2000) Sonographic and clinical methods in the diagnosis of macrosomia. Clin Obstet Gynecol 43:309–320PubMedCrossRefGoogle Scholar
- Ott WJ (1988) The diagnosis of altered fetal growth. Obstet Gynecol 15:237–263Google Scholar
- Ott WJ (1991) Value of fetal umbilical artery and carotid doppler flow studies in the evaluation of suspected IUGR. J Matern Fetal Invest 1:185–190Google Scholar
- Ott WJ (1999) Altered fetal growth. In: Ott WJ (ed) Clinical obstetrical ultrasound. Wiley-Liss, New York, pp 229–262Google Scholar
- Ott WJ (2001) The ultrasonic diagnosis and evaluation of intrauterine growth restriction. Ultrasound Rev Obstet Gynecol 1:205–215CrossRefGoogle Scholar
- Pattinson RC, Odendaal HJ, Kisten G (1993) The relationship between absent end-diastolic velocities of the umbilical artery and perinatal mortality and morbidity. Early Hum Dev 33:61–9PubMedCrossRefGoogle Scholar
- Petrikovski BM, Oleschuk C, Lesser M, Gelertner N, Gross B (1997) Prediction of fetal macrosomia using sonographically measured abdominal subcutaneous tissue thickness. J Clin Ultrasound 25:378–382CrossRefGoogle Scholar
- Phelan JP, Ahn MO, Smith CV, Rutherford SE, Anderson E (1987) Amniotic fluid index measurements during pregnancy. J Reprod Med 32:601–604PubMedGoogle Scholar
- Pourcelot L (1974) Application clinique de l’examen Doppler transcutane. In: Peronneau P (ed) Velocimetric ultrasonore Doppler. INSERM, Paris, pp 213–240Google Scholar
- Proud J, Grant AM (1987) Third trimester placental grading by ultrasonography as a test of fetal well-being. BMJ 294:1641–1644PubMedCrossRefGoogle Scholar
- Roberts AB, Mitchell JM, McCowan LM, Barker S (1999) US measurements in the SGA fetus. Am J Obstet Gynecol 180:634–638PubMedCrossRefGoogle Scholar
- Rotmensch S, Celentano C, Liberati M, et al (1999) Screening efficacy of the subcutaneous tissue width/femur length ratio for fetal macrosomia in the nondiabetic pregnancy. Ultrasound Obstet Gynecol 13:340–344PubMedCrossRefGoogle Scholar
- Sacks DA, Chen W (2000) Estimation of fetal weight in the management of macrosomia. Obstet Gynecol Surv 55:229–239PubMedCrossRefGoogle Scholar
- Schauseil-Zipf U, Hamm W, Stenzel B, Bolte A, Gladtke E (1989) Severe intrauterine growth retardation: obstetrical management and follow-up studies in children born between 1970 and 1985. Eur J Obstet Gynecol Reprod Biol 30:1–9PubMedCrossRefGoogle Scholar
- Schild RL, Fimmers R, Hansmann M (2000) Fetal weight estimation by three-dimensional ultrasound. Ultrasound Obstet Gynecol 16:445–452PubMedCrossRefGoogle Scholar
- Secher NJ, Kern Hansen P, Lenstrup C, Sindberg Eriksen P, Morsing GA (1987) A randomized study of fetal abdominal diameter and fetal weight estimation for detection of light for gestation infants in low risk pregnancies. Br J Obstet Gynecol 94:105–109CrossRefGoogle Scholar
- Seeds JW (1984) Impaired fetal growth: definition and clinical diagnosis. Obstet Gynecol 64:415–422Google Scholar
- Senat MV, Schwarzler P, Alcais A, et al (2000) Longitudinal changes in the ductus venosus, cerebral transverse sinus and cardiotogram in fetal growth restriction. Ultrasound Obstet Gynecol 16:19–24PubMedCrossRefGoogle Scholar
- Severi FM, Rizzo G, Bocchi C, D’Antona D, Verzuri MS, Arduini D (2000) Intrauterine growth retardation and fetal cardiac function. Fetal Diagn Ther 15:8–19PubMedCrossRefGoogle Scholar
- Smith GC, Smith MF, McNay MB, Fleming JE (1997) The relation between fetal abdominal circumference and birthweights: findings in 3512 pregnancies. Br J Obstet Gynaecol 104:186–190PubMedCrossRefGoogle Scholar
- Sokol RJ, Chik L, Dombrowski MP, Zador I (2000) Correctly identifying the macrosomic fetus: improving ultrasonography-based prediction. Am J Obstet Gynecol 182:1489–1496PubMedCrossRefGoogle Scholar
- Sood AK, Yancey M, Richards D (1995) Prediction offetal macrosomia using humeral soft tissue thickness. Obstet Gynecol 85:937–940PubMedCrossRefGoogle Scholar
- Sterne G, Shields LE, Dubinsky TJ (2001) Abnormal fetal cerebral and umbilical Doppler measurements in fetuses with intrauterine growth restriction predicts the severity of perinatal morbidity. J Clin Ultrasound 29:146–151PubMedCrossRefGoogle Scholar
- Stigter RH, Mulder EJH, Bruinse HW, Visser GHA (2001) Doppler studies on the fetal renal artery in the severely growth-restricted fetus. Ultrasound Obstet Gynecol 18:141–145PubMedCrossRefGoogle Scholar
- Tonsong T, Wanapirek C, Thongpaduroy T (1999) US diagnosis of IUGR by transverse cerebellar (TCD)/abdominal circumference (AC) ratio. Int J Gynaecol 180:634–638Google Scholar
- Tukeva TA, Salmi H, Poutanen VP, Karjalainen PT, Hytinantti T, Paavonen J, Teramo KA, Aronen HJ (2001) Fetal shoulder measurements by fast and ultrafast MRI techniques. J Magn Reson Imaging 13:938–942PubMedCrossRefGoogle Scholar
- Udall JN, Harrison GG, Vaucher Y, et al (1978) Interaction of maternal and neonatal obesity. Pediatrics 62:17PubMedGoogle Scholar
- Varma TR (1984) Low birth weight babies. The small-forgestational age: a review of current management. Obstet Gynecol Surv 39:616–631PubMedCrossRefGoogle Scholar
- Vossbeck S, Kraus de Camargo O, Grab D, Bode H, Pohlandt F (2001) Neonatal and neurodevelopmental outcome in infants born before 30 weeks of gestation with absent or reversed end-diastolic fiow velocities in the umbilical artery. Eur J Pediatr 160: 128–134PubMedCrossRefGoogle Scholar
- Vyas S, Nicolaides KH, Campbell S (1989) Renal artery fiowvelo city waveforms in normal and hypoxemic fetuses. Am J Obstet Gynecol 161:168–172PubMedCrossRefGoogle Scholar
- Wienerroither H, Steiner H, Tomaselli J, Lobendanz M, Thun-Hohenstein L (2001) Intrauterine blood fiow and long-term intellectual, neurologie, and social development. Obstet Gynecol 97:449–453PubMedCrossRefGoogle Scholar
- Williams H, Stgeorge IM, Silva PA (1992) IUGR and blood pressure at age 7 and 18. J Clin Epidemiol 45:1257–1263PubMedCrossRefGoogle Scholar
- Wladimiroff JW, Bloesma CA, Wallenburg HCS (1978) Ultrasonic diagnosis of large for dates infants. Obstet Gynecol 52:285–288PubMedGoogle Scholar
- Woo JK, Liang ST, Chan FY (1987) Middle cerebral artery doppler fiow velocity waveforms. Obstet Gynecol 70:613–616PubMedGoogle Scholar
- Zelop CM (2000) Prediction of fetal weight with the use of three-dimensional ultrasonography. Clin Obstet Gynecol 43:321–325PubMedCrossRefGoogle Scholar