Iatrogenic Lymphoproliferative Disorders in Non-Transplantation Settings

  • Onsi W. Kamel
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 159)

Abstract

Over the last decade, it has become clear that iatrogenic immunodeficiency-related lymphoproliferative disorders can occur in non-transplantation settings. These lymphoproliferative disorders occur predominantly in patients with rheumatologic diseases who are treated with immunomodulatory drugs. Luce immunodeficiency-related lymphoproliferations in other settings, these represent a spectrum of lymphoid neoplasms and are frequently associated with Epstein-Barr virus. The distribution of histologic types of iatrogenic lymphoproliferations in non-transplantation settings appears to differ from that seen in other immunodeficiency settings with a probable increase in representation of Hodgkin’s disease and lymphoproliferations resembling Hodgkin’s disease. Recognition of these immunodeficiency-related lymphoproliferative disorders is important for appropriate patient management.

Keywords

Cancer Research Clinical Setting Histologic Type Patient Management Lymphoproliferative Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Nalesnik MA, Makowka L, Starzl TE (1988) The diagnosis and treatment of posttransplant lymphoproliferative disorders. Curr ProbI Surg 25:367–472CrossRefGoogle Scholar
  2. 2.
    Biemer JJ (1990) Malignant lymphomas associated with immunodeficiency states. Ann Clin Lab Sci 20:175–191PubMedGoogle Scholar
  3. 3.
    Cobeta-Garcia JC, Ruiz-Jimeno MT, Fontova-Garrofe R (1993) Non-Hodgkin’s lymphoma, rheumatoid arthritis and methotrexate (letter). J Rheumatol 20:200–202PubMedGoogle Scholar
  4. 4.
    Ellman MH, Hurwitz H, Thomas C, et al (1991) Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate. J Rheumatol 18:1741–1743PubMedGoogle Scholar
  5. 5.
    Ferraccioli GF, Casatta L, Bartoli E, et al (1995) Epstein-Barr virus associated Hodgkin’s lymphoma in a rheumatoid arthritis patient treated with methotrexate and cyclosporin A (letter). Arthritis Rheum 6:867–868CrossRefGoogle Scholar
  6. 6.
    Kamel OW, van de Rijn M, Weiss LM, et al (1993) Reversible lymphomas associated with Epstein-Barr virus occurring during methotrexate therapy for rheumatoid arthritis and dermatomyositis. N Engl J Med 328:1317–1321PubMedCrossRefGoogle Scholar
  7. 7.
    Kamel OW, van de Rijn M, LeBrun DP, et al (1994) Lymphoid neoplasms in patients with rheumatoid arthritis and dermatomyositis: frequency of Epstein-Barr virus and other features associated with immunosuppression. Hum Pathol 25:638–643PubMedCrossRefGoogle Scholar
  8. 8.
    Kamel OW, Weiss LM, van de Rijn M, et al (1996) Hodgkin’s disease and lymphoproliferations resembling Hodgkin’s disease in patients receiving longterm, low-dose methotrexate therapy. Am J Surg Pathol 20:1279–87PubMedCrossRefGoogle Scholar
  9. 9.
    Kamel OW, Holly EA, van de Rijn M, et al (L999) A population-based casecontrol study of non-Hodgkin’s lymphoma in patients with rheumatoid arthritis. J. Rheumatol 26:1176–80Google Scholar
  10. 10.
    Kingsmore SR Hail BD, Allen NB, et al (1992) Association of methotrexate, rheumatoid arthritis and lymphoma: report of 2 cases and literature review. J Rheumatol 19:1462–1465PubMedGoogle Scholar
  11. 11.
    Kono H, Inokuma S, Matsuzaki T, et al (1999) Two cases of methotrexate induced lymphomas in rheumatoid arthritis: an association with increased serum IgE. J Rheumatol 26:2249–2253PubMedGoogle Scholar
  12. 12.
    Morris CR, Morris AJ (1993) Localized lymphoma in a patient with rheumatoid arthritis treated with parenteral methotrexate (letter). J Rheumatol 20: 2172–2173PubMedGoogle Scholar
  13. 13.
    SaUoum E, Cooper DL, Gowe G, et al (1996) Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases. J Clin Oncol 14:1943–1949Google Scholar
  14. 14.
    Shiroky JB, Frost A, Skelton JD, et al (1991) Complications of immunosuppression associated with weekly low dose methotrexate. J Rheumatol 18: 1172–1175PubMedGoogle Scholar
  15. 15.
    Shiroky JB, Newkirk MM (1993) Reversible lymphomas (letter). N Engl J Med 329:1658CrossRefGoogle Scholar
  16. 16.
    Taillan B, Garnier G, Castanet J, et al (1993) Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate. CEn Rheum 12:93–94CrossRefGoogle Scholar
  17. 17.
    Thomason RW, Craig FE, Banks PM, et al (1996) Epstein-Barr virus and lymphoproliferation in methotrexate treated rheumatoid arthritis. Mod Pathol 9:261–266PubMedGoogle Scholar
  18. 18.
    van de Rijn M, Cleary ML, Variakojis D, et al (1996) Epstein-Barr virus clonality in lymphomas occurring in patients with rheumatoid arthritis. Arthritis Rheum 39:638–642PubMedCrossRefGoogle Scholar
  19. 19.
    Zijimans JM, van Rijthoven AW, Kluin PM, et al (1992) Epstein-Barr virus associated lymphoma in a patient with rheumatoid arthritis treated with cyclosporine (letter). N Engl J Med 326:1363Google Scholar
  20. 20.
    Zimmer-GaUer I, Lie JT (1994) Choroidal infiltrates as the initial manifestation of lymphoma in rheumatoid arthritis after treatment with low-dose methotrexate. Mayo Clin Proc 69:259–262Google Scholar
  21. 21.
    American College of Rheumatology Ad Hoc Committee on Clinical Guidelines (1996) Guidelines for the management of rheumatoid arthritis. Arthritis Rheum 39:713–722CrossRefGoogle Scholar
  22. 22.
    Garnier JL, Cooper NR, Cannon MJ (1993) Low expression of CD20 and CD23 in Epstein-Barr virus-induced B cell tumors in SCID/hu mice. Am J Pathol 142:353–358PubMedGoogle Scholar
  23. 23.
    Gelb AB, Rouse RV, Dorfman RF, et al (1994) Detection of immunophenotypic abnormalities in paraffm-embedded B-lineage non-Hodgkin’s lymphomas. Am J Clin Pathol 102:825–834PubMedGoogle Scholar
  24. 24.
    Ambinder RF, Mann RB (1994) Detection and characterization of Epstein-Barr virus in clinical specimens. Am J Pathol 145:239–252PubMedGoogle Scholar
  25. 25.
    Jaccard A, Emile JF, Metivier F, et al (1994) Epstein-Barr virus associated Hodgkin’s disease following renal transplantation. Am J Hematol 46:256–257PubMedCrossRefGoogle Scholar
  26. 26.
    Nalesnik MA, Randhawa P, Bemetris AJ, et al (1993) Lymphoma resembling Hodgkin’s disease after posttransplant lymphoproliferative disorder in a liver transplant patient. Cancer 72:2568–2573PubMedCrossRefGoogle Scholar
  27. 27.
    Levy R, Kaplan HS (1974) Impaired lymphocyte function in untreated Hodgkin’s disease. N Engl J Med 290:181–186PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Onsi W. Kamel
    • 1
  1. 1.Department of Laboratory MedicineSt. John’s HospitalSpringfieldUSA

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