Cytoskeletal Competence Requires Protein Chaperones

  • Roy Quinlan
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 28)


The cytoskeleton is the internal structure of the cell that makes diverse cellular functions possible. These structures are extremely dynamic, undergoing continual remodelling within the cytoplasm and requiring continual change in the protein-protein interactions as part of their function. It is therefore not surprising that cytoskeletal proteins require the attention of protein chaperones at all stages of their life. Initially, chaperonins ensure the nascent chains of actin and tubulin fold correctly as they emerge from the ribosome and in this review, the role of the small heat shock proteins (sHSPs) in further cytoskeletal function will be discussed. Chaperones are most certainly important components in the birth and life of the cytoskeleton.


Glial Fibrillary Acid Protein Intermediate Filament Small Heat Shock Protein Actin Assembly Intermediate Filament Network 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Roy Quinlan
    • 1
  1. 1.Department of Biological SciencesDurhamUK

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