Abstract
Clinical small bowel transplantation has been rarely performed in Germany, because of the high risk for the development of acute rejection and rejection-associated complications. This included peritonitis and sepsis as well as over-immunosuppression-associated infections. Isolated small bowel transplantation was performed in 5 adult patients with short gut syndrome. All patients are alive with good graft function. Acute rejection was not observed so far. The incidence of infectious complication including bacterial and viral infections was low. This was achieved by a highly potent immunosuppressive management which was gradually tapered over time. The decrease in immunosuppression was guided by the use of soluble immune parameters and determination of cellular immune status. Last not least a great deal of attention was paid to preservation of mucosal gut flora and barrier function.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Sudan DL, Kaufman SS, Shaw BW, Fox IJ, McCashland TM, Schafer DF, Radio SJ, Hinrichs SH, Vanderhoof JA, Langnas AN (2000) Isolated intestinal transplantation for intestinal failure. AJG 95: 1506–1515
Abu-Elmagd K, Reyes J, Bond G, Mazariegos G, Wu T, Murase N, Sindhi R, Martin D, Colangelo J, Zak M, Parm DJ, Ezzelarab M, Dvorcjik I, Parizhskaya M, Detsch M, Demetris A, Fung J, Arzl TE (2001) Clinical intestinal transplantation: a decade of experience at a Single center. Ann Surg 234: 404–417
Lee RG, Nakamura K, Tsamandas AC, Demetris A (1996) Pathology of human intestinal Transplantation. Gastroenterology 110: 2009–2012
Müller AR, Langrehr JM, Nalesnik M, Hoffman RA, Lee TK, Lee KKW, Schraut WH (1994) Mucosal glutaminase acitivy andhistology as parameters of small bowel preservation injury. J Surg Res 56: 207–213
Müller AR, Platz KP, Neuhaus P (2001) Dünndarmtransplantation (DTX). In Pfitzmann R, Neuhaus P, Hetzer R (Hrsg) Organtransplantation - Transplantation thorakaler und abdomieller Organe. Walter de Gruyter, Berlin - New York, S. 217–238
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Müller, A.R. et al. (2002). Klinische Dünndarmtransplantation — auf dem Weg zur etablierten Therapie?. In: Chirurgisches Forum 2002. Deutsche Gesellschaft für Chirurgie, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56158-0_72
Download citation
DOI: https://doi.org/10.1007/978-3-642-56158-0_72
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-43300-2
Online ISBN: 978-3-642-56158-0
eBook Packages: Springer Book Archive