Prospects for Vitamin D receptor Modulators as Candidate Drugs for Cancer and (Auto)immune Diseases

  • Roger Bouillon
  • Annemieke Verstuyf
  • Lieve Verlinden
  • Guy Eelen
  • Chantal Mathieu
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 164)

Abstract

The development of less calcemic vitamin D analogs creates possible therapeutic applications for immune modulation (e.g., autoimmune diseases and graft rejection), inhibition of cell proliferation and induction of cell differentiation (e.g., cancer). Recently more insight was obtained in the mechanism of action of the analogs at the biological and molecular level. Critical remarks are summarized on why the step towards the clinic has not yet been taken and how better selective vitamin D receptor modulators could be designed.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Roger Bouillon
    • 1
  • Annemieke Verstuyf
  • Lieve Verlinden
  • Guy Eelen
  • Chantal Mathieu
  1. 1.LegendoKU LeuvenLeuvenBelgium

Personalised recommendations