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Exogenous Porcine Viruses

  • P. S. Paul
  • P. Halbur
  • B. Janke
  • H. Joo
  • P. Nawagitgul
  • J. Singh
  • S. Sorden
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 278)

Abstract

Porcine organs, cells and tissues provide a viable source of transplants in humans, though there is some concern of public health risk from adaptation of swine infectious agents in humans. Limited information is available on the public health risk of many exogenous swine viruses, and reliable and rapid diagnostic tests are available for only a few of these. The ability of several porcine viruses to cause transplacen126 P. S. Paul et al.tal fetal infection (parvoviruses, circoviruses, and arteriviruses), emergenceor recognition of several new porcine viruses during the last two decades (porcine circovirus, arterivirus, paramyxoviruses, herpesviruses, and porcine respiratory coronavirus) and the immunosuppressed state of the transplant recipients increases the xenozoonoses risk of humans to porcine viruses through transplantation. Much of this risk can be eliminated with vigilance and sustained monitoring along with a better understanding of pathogenesis and development of better diagnostic tests. In this review we present information on selected exogenous viruses, highlighting their characteristics, pathogenesis of viral infections in swine, methods for their detection, and the potential xenozoonoses risk they present. Emphasis has been given in this review to swine influenza virus, paramyxovirus (Nipah virus, Menagle virus, LaPiedad paramyxovirus, porcine paramyxovirus), arterivirus (porcine reproductive and respiratory syndrome virus) and circovirus as either they represent new swine viruses or present the greatest risk. We have also presented information on porcine parvovirus, Japanese encephalitis virus, encephalomyocarditis virus, herpesviruses (pseudorabies virus, porcine lymphotropic herpesvirus, porcine cytomegalovirus), coronaviruses (TGEV,PRCV, HEV, PEDV) and adenovirus. The potential of swine viruses to infect humans needs to be assessed in vitro and in vivo and rapid and more reliable diagnostic methods need to be developed to assure safe supply of porcine tissues and cells for xenotransplantation.

Keywords

Swine Influenza Virus Respiratory Syndrome Virus Japanese Encephalitis Virus Nipah Virus Postweaning Multisystemic Wasting Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • P. S. Paul
    • 1
  • P. Halbur
    • 2
  • B. Janke
    • 2
  • H. Joo
    • 3
  • P. Nawagitgul
    • 4
  • J. Singh
    • 2
  • S. Sorden
    • 2
  1. 1.Department of Veterinary and Biomedical SciencesUniversity of Nebraska-LincolnLincolnUSA
  2. 2.College of Veterinary MedicineIowa State UniversityAmesUSA
  3. 3.College of Veterinary MedicineUniversity of MinnesotaSaint PaulUSA
  4. 4.Faculty of Veterinary MedicineKasetsart UniversityKasetsartThailand

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