• Toyoharu Isawa


The lung functions as a gas exchanger of oxygen and carbon dioxide, which we call respiration. Respiration consists of perfusion, ventilation, and diffusion (Fig. 22.1). Oxygen delivered to the peripheral tissues and cells, including the cells in the lungs, is mainly utilized through mitochondrial cytochrome oxidase to generate ATP (Fisher and Forman 1985). In addition to its respiratory function, the lung is responsible for such nonrespiratory functions as mucociliary clearance (an important body defense), maintenance of pulmonary epithelial permeability, uptake of various substances, cellular upkeep metabolism, and so on (Fig. 22.2).


Chronic Obstructive Pulmonary Disease Mucociliary Clearance Hypoxic Pulmonary Vasoconstriction Regional Perfusion Terminal Bronchiole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Agnew JE (1984) Physical properties and mechanism of deposition of aerosols. In: Clarke SW, Pavia D (eds) Aerosol and the lung, chap 3. Butterworths, London, pp 49–70Google Scholar
  2. Alpert JS, Smith R, Carlson J et al (1976) Mortality in patients treated for pulmonary embolism. JAMA 236:1477–1480PubMedGoogle Scholar
  3. Altshuler B, Palmes ED, Yarmus L et al (1959) Intrapulmonary mixing of gases studied with aerosols. J Appl Physiol 14:321–327PubMedGoogle Scholar
  4. Anazawa Y, Isawa T, Teshima T et al (1991) Pulmonary epithelial permeability in normal subjects and patients with idiopathic interstitial pneumonia. J Jpn Soc Chest Dis 29:1439–1443Google Scholar
  5. Anazawa Y, Isawa T, Teshima T et al (1992a) Changes in pulmonary epithelial permeability due to thoracic irradiation. J Jpn Soc Chest Dis 30:862–867Google Scholar
  6. Anazawa Y, Isawa T, Teshima T et al (1992 b) Pulmonary epithelial permeability in rats with bleomycin-induced pneumonitis. J Jpn Soc Chest Dis 30:1222–1228Google Scholar
  7. Baetjer AM (1967) Effect of ambient temperature and vapor pressure on cilia-mucus clearance rate. J Appl Physiol 23:498–504PubMedGoogle Scholar
  8. Bass H, Henderson JAM, Heckscher T et al (1968) Regional structure and function in bronchiectasis. A correlative study using bronchography and 133Xe. Am Rev Respir Dis 97:598–609PubMedGoogle Scholar
  9. Baum G, Priel Z, Roth Yet al (eds) (1998) Cilia, mucus, and mucociliary interactions. Dekker, New York, pp 1–584Google Scholar
  10. Benumof JL, Trousdale FR (1982) Aminophylline does not inhibit canine hypoxic pulmonary vasoconstriction. Am Rev Respir Dis 126:1017–1019PubMedGoogle Scholar
  11. Bergofsky EH, Holtzman S (1967) A study of the mechanisms involved in the pulmonary arterial response to hypoxia. Circ Res 20:506–519PubMedGoogle Scholar
  12. Berke HI, Roslinski LM (1971) The roentgenographic determination of tracheal mucociliary transport rate in the rat. Am Ind Hyg Assoc J 32:174–178PubMedGoogle Scholar
  13. Biello DR, Mattar AG, McKnight RC et al (1979) Ventilation-perfusion studies in suspected pulmonary embolism. AJR 133:1033–1037PubMedGoogle Scholar
  14. Boucher RC, Johnson J, Inoue S et al (1980) The effect of cigarette smoke on the permeability of guinea pig airways. Lab Invest 43:94–100PubMedGoogle Scholar
  15. Boulanger C, Luscher TF (1990) Release of endothelin from the porcine aorta: inhibition by endothelium-derived nitric oxide. J Clin Invest 85:587–590PubMedGoogle Scholar
  16. Bradley M, Nukiwa T, Crystal RG (1988) Molecular basis of alpha-1-antitrypsin deficiency. Am J Med 84:13–31Google Scholar
  17. Braude S, Nolop KB, Hughes JMB et al (1983) Comparison of lung vascular and epithelial permeability indices in the adult respiratory distress syndrome. Am Rev Respir Dis 133:1002–1005Google Scholar
  18. Braude S, Apperley J, Krausz T et al (1985) Adult respiratory distress syndrome after allogenic bone marrow transplantation: evidence for a neutrophil-independent mechanism. Lancet 1:1239–1242PubMedGoogle Scholar
  19. Burch WM, Sullivan PJ, McLaren CJ (1986) Technegas—a new ventilation agent for lung scanning. Nucl Med Commun 7:865–871PubMedGoogle Scholar
  20. Carson JL, Kelly MA, Duff A et al (1992) The clinical course of pulmonary embolism. N Engl J Med 326:1240–1245PubMedGoogle Scholar
  21. Chacon RA, Corris PA, Dark JH et al (1998) Comparison of the functional results of single lung transplantation for pulmonary fibrosis and chronic airway disease. Thorax 53:43–49PubMedGoogle Scholar
  22. Chopra KS, Taplin GV, Tashkin DP et al (1979) Lung clearance of soluble aerosols of different molecular weights in systemic sclerosis. Thorax 34:63–67PubMedGoogle Scholar
  23. Chung S-K, Kim H-H, Bahk Y-W (1997) Prestenotic bronchial radioaerosol deposition: A new ventilation scan sign of bronchial obstruction. J Nucl Med 38:71–74PubMedGoogle Scholar
  24. Coates G, O’Brodovich H (1986) Measurement of pulmonary epithelial permeability with 99mTc-DTPA aerosol. Semin Nucl Med 16:275–284PubMedGoogle Scholar
  25. Cook GJR, Fogelman I (1996) Pseudo pulmonary embolism in complex heart disease. J Nucl Med 37:1359–1361PubMedGoogle Scholar
  26. Cooper JD, Patterson GA, Sundaresan RS et al (1996) Results of 150 consecutive bilateral lung volume reduction procedures in patients with severe emphysema. J Thorac Cardiovasc Surg 112:1319–1329PubMedGoogle Scholar
  27. Criley JM, Ross RS (1971) Introduction to methods. In: Cardiopulmonary physiology. Oldsman, Tampa Tracing, pp 1–34Google Scholar
  28. Cumming G, Crank J, Horsfield K et al (1966) Gaseous diffusion in the airways of the human lung. Respir Physiol 1:58–78PubMedGoogle Scholar
  29. Dalen JE, Alpert JS (1975) Natural history of pulmonary embolism. Prog Cardiovasc Dis 17:257–270Google Scholar
  30. Eliasson R, Mossberg B, Camner P et al (1977) The immotile-cilia syndrome. A congenital ciliary abnormality as an etiologic factor in chronic airway infections and male sterility. N Engl J Med 297:1–6PubMedGoogle Scholar
  31. Engel L (1978) Gas mixing within the acinus of the lung. J Appl Physiol 54:416–423Google Scholar
  32. Fisher AB, Forman HJ (1985) Oxygen utilization and toxicity in the lungs. In: Fishman AP, Fisher AB (eds) Handbook of physiology, chap 5, sect 3. The respiratory system. American Physiological Society, Bethesda, pp 231–254Google Scholar
  33. Foord N, Black A, Walsh M (1978) Regional deposition of 2.5-7.5 εrn diameter inhaled particles in healthy male nonsmokers. J Aerosol Sci 9:343–357Google Scholar
  34. Forster RE II, DuBois AB, Briscoe WA, Fisher AB (1986) Physiologic dead space. Appendix C. In: The lung. Physiologic basis of pulmonary function tests, 3rd edn. Year Book Medical, Chicago, pp 266–267Google Scholar
  35. Fraser RG (1961) Measurement of the calibre of human bronchi in three phases of respiration by cine bronchography. J Can Assoc Radiol 12:102–112PubMedGoogle Scholar
  36. Freitas JE, Sarosi MG, Nagle CC et al (1995) Modified PIOPED criteria used in clinical practice. J Nucl Med 36:1573–1578PubMedGoogle Scholar
  37. Friedman M, Scott FD, Poole DO et al (1977) A new roent-genologic method for estimating mucous velocity in airways. Am Rev Respir Dis 115:67–72PubMedGoogle Scholar
  38. Frostell CG, Bromqvist H, Hedenstierna G et al (1993) Inhaled nitric oxide selectivity reverses human hypoxic pulmonary vasoconstriction without causing systemic vasoconstriction. Anesthesiology 78:427–435PubMedGoogle Scholar
  39. Furman WR, Summer WR, Kennedy TP et al (1982) Comparison of the effects of dobutamine, dopamine, and isoproterenol on hypoxic pulmonary vasoconstriction in the pig. Crit Care Med 10:371–374PubMedGoogle Scholar
  40. Geroulakos G (2001) The risk of venous thromboembolism. The evidence is only circumstantial. BMJ 322:188PubMedGoogle Scholar
  41. Gil J, Weibel ER (1971) Extracellular lining of bronchioles after perfusion-fixing of rat lungs for electron microscopy. Anat Rec 169:185–200PubMedGoogle Scholar
  42. Goldberg SN, Richardson DD, Palmer EL et al (1996) Pleural effusion and ventilation/perfusion scan interpretation for acute pulmonary embolus. J Nucl Med 37:1310–1313PubMedGoogle Scholar
  43. Gorin AB, Stewart PA (1979) Differential permeability of endothelial and epithelial barriers to albumin flux. J Appl Physiol 47:1315–1324PubMedGoogle Scholar
  44. Gottschalk A (2000) The chronic perfusion defect: our knowledge is still hazy, but the message is clear. J Nucl Med 41:1049–1050PubMedGoogle Scholar
  45. Gottschalk A, Stein PD, Henry JW et al (1996) Matched ventilation, perfusion and chest radiographic abnormalities in acute pulmonary embolism. J Nucl Med 37:1636–1638PubMedGoogle Scholar
  46. Greenstone MA, Rutman A, Hendry WF et al (1988) Ciliary function in Young’s syndrome. Thorax 43:153–154PubMedGoogle Scholar
  47. Greenwood MF, Holland P (1972) The mammalian respiratory tract surface. A scanning electron microscopic study. Lab Invest 27:296–304PubMedGoogle Scholar
  48. Groskin SA (1993) Subsegmental anatomy of the lung. In: Groskin SA (ed) Heitzman’s The lung, 3rd edn, chap 4. Mosby Year Book, St Louis, pp 43–69Google Scholar
  49. Gross NJ (1977) Pulmonary effects of radiation therapy. Ann Intern Med 86:81–92PubMedGoogle Scholar
  50. Haas F, Bergofsky EH (1972) Role of the mast cell in the pulmonary pressor response to hypoxia. J Clin Invest 51:3154–3162PubMedGoogle Scholar
  51. Harvey BG, Leopold PL, Hackett NR et al (1999) Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus. J Clin Invest 104:1245–1255PubMedGoogle Scholar
  52. Hemsen A, Franco-Cereceda A, Matran R et al (1990) Occurrence, specific binding sites and functional effects of endothelin in human cardiopulmonary tissue. Eur J Pharmacol 191:319–328PubMedGoogle Scholar
  53. Hilding AC (1957) Ciliary streaming in the bronchial tree and the time element in carcinogenesis. N Engl J Med 256:634–640PubMedGoogle Scholar
  54. Hirano T (1988) Mucociliary clearance mechanisms. I. Canine tracheal mucous velocity and different particles sizes. Kohkenshi 40:107–113Google Scholar
  55. Hogg JC (1983) The effect of smoking on airway permeability (editorial). Chest 83:1–2PubMedGoogle Scholar
  56. Homans J (1954) Thrombosis of the deep leg veins due to prolonged sitting. N Engl J Med 250:148–149PubMedGoogle Scholar
  57. Horikoshi M, Teshima T, Yanagimachi T et al (2000) 99mTc technegas imaging in lung cancer. Jpn J Clin Radiol 45:187–198Google Scholar
  58. Hughes JMB, Glazier JB, Malorey JE et al (1967) Effect of interstitial pressure on pulmonary blood flow. Lancet 1:192–193PubMedGoogle Scholar
  59. Hunninghake GW, Crystal RG (1983) Cigarette smoking and lung destruction: accumulation of neutrophils in the lungs of cigarette smokers. Am Rev Respir Dis 128:833–838PubMedGoogle Scholar
  60. Ikonen T, Harjula AL, Kinnula V et al (1996) Selective assessment of single-lung graft function with 133Xe radio-spirometry in acute rejection and infection. Chest 109:879–884PubMedGoogle Scholar
  61. Ikonen T, Sovijarvi AR, Taskinen E et al (1997) Detection of acute rejection by 133Xe radiospirometry after single lung transplantation in an experimental porcine model. Eur Surg Res 29:12–19PubMedGoogle Scholar
  62. Isawa T (1995) Radioaerosol lung imaging—history and Pharmaceuticals. In: Bahk YW, Isawa T (eds) Radioaero-sol imaging of the lung. IAEA, Vienna, pp 16–23Google Scholar
  63. Isawa T, Shiraishi K, Yasuda T et al (1967) Effect of oxygen concentration in inspired gas upon pulmonary arterial blood flow. Am Rev Respir Dis 96:1199–1208PubMedGoogle Scholar
  64. Isawa T, Okubo K, Oka S (1969) Postural effect on regional ventilation. Tohoku J Exp Med 97:101–112PubMedGoogle Scholar
  65. Isawa T, Wasserman K, Taplin GV (1970 a) Lung scintigra-phy and pulmonary function studies in obstructive airway disease. Am Rev Respir Dis 102:161–172PubMedGoogle Scholar
  66. Isawa T, Wasserman K, Taplin GV (1970 b) Variability of lung scans following pulmonary embolization. A concept of regional pulmonary ischemia of functional origin. Am Rev Respir Dis 101:207–217PubMedGoogle Scholar
  67. Isawa T, Benfield JR, Johnson DE et al (1971a) Pulmonary perfusion changes after experimental unilateral bronchial occlusion and their clinical implications. Radiology 99:355–360PubMedGoogle Scholar
  68. Isawa T, Hayes M, Taplin GV (1971b) Radioaerosol inhalation lung scanning: its role in suspected pulmonary embolism. J Nucl Med 12:606–609PubMedGoogle Scholar
  69. Isawa T, Taplin GV, Beazell J et al (1972) Experimental unilateral pulmonary artery occlusion. Acute and chronic effect on relative inhalation and perfusion. Radiology 102:101–109PubMedGoogle Scholar
  70. Isawa T, Teshima T, Hirano T et al (1978 a) Regulation of regional perfusion distribution in the lungs. Experimental models and effect of alveolar pressure. Tohoku J Exp Med 124:33–46PubMedGoogle Scholar
  71. Isawa T, Teshima T, Hirano T et al (1978b) Regulation of regional perfusion distribution in the lungs. Effect of regional oxygen concentration. Am Rev Respir Dis 118:55–63PubMedGoogle Scholar
  72. Isawa T, Teshima T, Hirano T et al (1979) Effect of amino-phylline on regional perfusion distribution in the lungs. Tohoku J Exp Med 128:345–353PubMedGoogle Scholar
  73. Isawa T, Hirano T, Teshima T et al (1980 a) Effect of nonfiltered and filtered cigarette smoke on mucociliary clearance mechanism. Tohoku J Exp Med 130:189–197PubMedGoogle Scholar
  74. Isawa T, Teshima T, Hirano T et al (1980 b) Effect of alveolar hypercapnia on regional pulmonary perfusion. Tohoku J Exp Med 132:187–197PubMedGoogle Scholar
  75. Isawa T, Teshima T, Hirano T et al (1981 a) Effect of isoproterenol on regional pulmonary perfusion and its blockade by propranolol. Tohoku J Exp Med 134:59–69PubMedGoogle Scholar
  76. Isawa T, Teshima T, Hirano T et al (1981b) Effect of dopamine on regional pulmonary perfusion. Tohoku J Exp Med 134:71–77PubMedGoogle Scholar
  77. Isawa T, Teshima T, Hirano T et al (1981c) Radioaerosol inhalation lung cine-scintigraphy: a preliminary report. Tohoku J Exp Med 134:245–255PubMedGoogle Scholar
  78. Isawa T, Teshima T, Hirano T et al (1982) Effect of isoproterenol on regional pulmonary perfusion in the reimplanted lung of the dog. Tohoku J Exp Med 136:163–168PubMedGoogle Scholar
  79. Isawa T, Teshima T, Hirano T et al (1984 a) Mucociliary clearance mechanisms in smoking and nonsmoking normal subjects. J Nucl Med 25:352–359PubMedGoogle Scholar
  80. Isawa T, Teshima T, Hirano T et al (1984 b) Lung clearance mechanisms in obstructive airways disease. J Nucl Med 25:447–454PubMedGoogle Scholar
  81. Isawa T, Teshima T, Hirano T et al (1984 c) Evaluation of mucociliary clearance mechanisms by radioaerosol inhalation lung scintigraphy—effect of oral bromhexine. J Jpn Soc Chest Dis 22:899–909Google Scholar
  82. Isawa T, Teshima T, Hirano T et al (1986 a) Mucociliary clearance mechanism in interstitial lung disease. Tohoku J Exp Med 148:169–178PubMedGoogle Scholar
  83. Isawa T, Teshima T, Hirano T et al (1986 b) Effect of oral salbutamol on mucociliary clearance mechanisms in the lungs. Tohoku J Exp Med 150:51–61PubMedGoogle Scholar
  84. Isawa T, Teshima T, Hirano T et al (1986 c) Mucociliary clearance mechanisms in lung cancer. Kohkenshi 38:147–157Google Scholar
  85. Isawa T, Teshima T, Hirano T et al (1987) Effect of broncho-dilation on the deposition and clearance of radioaerosol in bronchial asthma in remission. J Nucl Med 28:1901–1906PubMedGoogle Scholar
  86. Isawa T, Teshima T, Hirano T et al (1988) Mucociliary clearance in pulmonary vascular disease. Ann Nucl Med 2:41–47PubMedGoogle Scholar
  87. Isawa T, Teshima T, Hirano T et al (1989) Normal values for quantitative parameters for evaluation of mucociliary clearance in lungs. Tohoku J Exp Med 158:119–131PubMedGoogle Scholar
  88. Isawa T, Teshima T, Hirano T et al (1990 a) Mucociliary clearance and transport in bronchiectasis: global and regional assessment. J Nucl Med 31:543–548PubMedGoogle Scholar
  89. Isawa T, Teshima T, Hirano T et al (1990 b) Does a beta 2-stimulator really facilitate mucociliary transport in the human lungs in vivo? Am Rev Respir Dis 141:715–720PubMedGoogle Scholar
  90. Isawa T, Teshima T, Anazawa Y et al (1994) Technegas versus krypton-81m as an inhalation agent. Comparison of pulmonary distribution at total lung capacity. Clin Nucl Med 19:1085–1090PubMedGoogle Scholar
  91. Isawa T, Teshima T, Anazawa Y et al (1995) Inhalation of pertechnegas: similar clearance from the lungs to that of inhaled pertechnetate aerosol. Nucl Med Commun 16:741–746PubMedGoogle Scholar
  92. Isawa T, Lee B-T, Hiraga K (1996) High-resolution electron microscopy of technegas and pertechnegas. Nucl Med Commun 17:147–152PubMedGoogle Scholar
  93. Jacob MP, Baughman RP, Hughes J et al (1965) Radioaerosol lung clearance in patients with active pulmonary sarcoidosis. Am Rev Respir Dis 131:687–689Google Scholar
  94. Jefferies AL, Coates G, O’Brodovich H (1984) Pulmonary epithelial permeability in hyaline-membrane disease. N EnglJ Med 311:1075–1080Google Scholar
  95. Jones JG, Lawler P, Crawley JCW et al (1980) Increased alveolar permeability in cigarette smokers. Lancet 1:66–68PubMedGoogle Scholar
  96. Jones JG, Minty BD, Royston D et al (1983) Carbohaemoglobin and pulmonary epithelial permeability in man. Thorax 38:129–133PubMedGoogle Scholar
  97. Kapanci T, Assimacopoulos A, Irle C et al (1974) Contractile interstitial cells. In pulmonary septa: a possible regulator of ventilation/perfusion ratio? Ultrastructural, immuno-fluorescence, and in vitro studies. J Cell Biol 60:375–392PubMedGoogle Scholar
  98. Kim CK, Heyman S (1989) Ventilation/perfusion mismatch caused by positive pressure ventilatory support. J Nucl Med 30:1268–1270PubMedGoogle Scholar
  99. Knipping HW, Bolt W, Venrath LM et al (1955) Eine neue Methode zur Prüfung der Herz-und Lungenfunktion. Die Funktionsanalyse in der Lungen-und Herzklinik mit Hilfe des radioaktiven Edelgas Xenon 133 (Isotopen-Thorakographie). Dtsch Med Wochenschr 80:1146–1147PubMedGoogle Scholar
  100. Kotrappa P, Raghunath B, Subramanyam PSS et al (1977) Scintigraphy of lungs with dry aerosol generation and delivery system: concise communication. J Nucl Med 18:1082–1085PubMedGoogle Scholar
  101. Kraaijenhagen RA, Haverkamp D, Koopman MM et al (2000) Travel and risk of venous thrombosis. Lancet 356:1492–1493PubMedGoogle Scholar
  102. Kuni CC, Ducret RP, Nakhleh RE et al (1993) Reverse mismatch between perfusion and aerosol ventilation in transplanted lungs. Clin Nucl Med 18:313–317PubMedGoogle Scholar
  103. Levine SM, Anzueto A, Peters JI et al (1994) Medium term functional results of single-lung transplantation for end-stage obstructive lung disease. Am J Respir Crit Care Med 150:398–402PubMedGoogle Scholar
  104. Lucas AM, Douglas LC (1934) Principles of underlying ciliary activity in the respiratory tract. IL A comparison of nasal clearance in man, monkey and other mammals. Acta Otolaryngol 20:518–541Google Scholar
  105. Luscher TF, Vanhoutte PM (1988) Endothelium-dependent responses in human blood vessels. Trends Pharmacol Sci 9:181–184PubMedGoogle Scholar
  106. Mant MJ, O’Brien BD, Thong KL et al (1977) Haemorrhagic complications of heparin therapy. Lancet 1:1133–1135PubMedGoogle Scholar
  107. Marks JD, Luce JM, Lazar NM et al (1985) Effect of increases in lung volume on clearance of aerosolized solute from human lungs. J Appl Physiol 59:1242–1248PubMedGoogle Scholar
  108. Mason GR, Effros RM, Uszler JM et al (1985) Small solute clearance from the lungs of patients with cardiogenic and noncardiogenic pulmonary edema. Chest 88:327–334PubMedGoogle Scholar
  109. Mason GR, Duane GB, Mena I et al (1987) Accelerated solute clearance in pneumocystis carinii pneumonia. Am Rev Respir Dis 135:864–868PubMedGoogle Scholar
  110. Matthys H, Koehler D (1980) Effect of theophylline on mucociliary transport in man. Eur J Respir Dis 109[Suppl]:98–102Google Scholar
  111. Meignan M, Guillon JM, Denis M et al (1990) Increased lung permeability in HIV-infected patients with isolated cytotoxic T-lymphocytic alveolitis. Am Rev Respir Dis 141:1241–1248PubMedGoogle Scholar
  112. Miki M, Isawa T, Teshima T et al (1992) Difference in inhaled aerosol deposition patterns in the lungs due to three different sized aerosols. Nucl Med Commun 13:553–562PubMedGoogle Scholar
  113. Milic-Emili J (1977) Ventilation. In: West JB (ed) Regional differences in the lung. Academic, New York, pp 167–199Google Scholar
  114. Milic-Emili J, Henderson JAM, Dolovich MB et al (1966) Regional distribution of inspired gas in the lung. J Appl Physiol 21:749–759PubMedGoogle Scholar
  115. Minty BD, Jordan C, Jones JG (1981) Rapid improvement in abnormal pulmonary epithelial permeability after stopping cigarettes. BMJ 282:1183–1186PubMedGoogle Scholar
  116. Monaghan P, van der Wall H, Mackey DWJ et al (1990) Detection of altered pulmonary epithelial permeability by a modified technegas technique. Eur J Nucl Med 16 [Suppl]:S149Google Scholar
  117. Monaghan P, Murray IPC, Mackey DWJ et al (1991) An improved radionuclide technique for the detection of altered pulmonary permeability. J Nucl Med 32:1945–1949PubMedGoogle Scholar
  118. Morgenroth ML, Reeves JT, Murphy RC et al (1984) Leukotriene synthesis and receptor blockade hypoxic pulmonary vasoconstriction. J Appl Physiol 56:1340–1346Google Scholar
  119. Morrow PE (1974) Aerosol characterization and deposition. Am Rev Respir Dis 110:88–99PubMedGoogle Scholar
  120. Morrow PE, Yu CP (1993) Models of aerosol behavior in airways and alveoli. In: Moren F, Dolovic MB, Newhouse MT, Newman SP (eds) Aerosols in medicine. Principles, diagnosis and therapy. Elsevier Science, Amsterdam, pp 157–193Google Scholar
  121. Morrow PE, Bates DV, Fish BR et al (1966) Deposition and retention models for internal dosimetry of the human respiratory tract. Health Phys 12:173–207PubMedGoogle Scholar
  122. Moser KM, Longo AM, Ashburn WL et al (1973) Spurious scintigraphic recurrence of pulmonary emboli. Am J Med 55:434–443PubMedGoogle Scholar
  123. Nair G, Samuel AM, Nambi KSV et al Urban air pollution and altered lung function. An east south and south-eastern Asian regional co-ordinated study (not yet published)Google Scholar
  124. Nolop KB, Maxwell DL, Royston D et al (1986) The effect of raised thoracic pressure and volume of 99mTc-DTPA clearance in humans. J Appl Physiol 60:1493–1497PubMedGoogle Scholar
  125. Otis AB, McKerrow CB, Bartlett A et al (1956) Mechanical factors in distribution of pulmonary ventilation. J Appl Physiol 8:427–443PubMedGoogle Scholar
  126. O’Doherty MJ, Page CL, Harrington C et al (1990) Hemophilia, AIDS and lung epithelial permeability. Eur J Haematol 44:252–256PubMedGoogle Scholar
  127. Pack RJ, Weddicombe JB (1984) Amine containing cells of the lung. Eur J Respir Dis 65:559–578PubMedGoogle Scholar
  128. Panoutsopoulos G, Ilias I, Christakopoulou I (2000) Transient right-to-left in massive pulmonary embolism. Ann Nucl Med 3:217–221Google Scholar
  129. Pavia D, Sutton PP, Lopez-Vidriero MT et al (1983) Drug effects on mucociliary function. Eur J Respir Dis 64[Suppl 128]:304–317Google Scholar
  130. Peterson BT, James HL, McLarty JW (1988) Effects of lung volume on clearance of solutes from the air spaces of the lungs. J Appl Physiol 64:1068–1075PubMedGoogle Scholar
  131. PIOPED Investigators (1990) Value of ventilation/perfusion scan in acute pulmonary embolism. JAMA 263:2753–2759Google Scholar
  132. Pircher HJ, Temple JR, Kirsch WJ et al (1965) Distribution of pulmonary ventilation determined by radioisotope scanning. AJR 94:807–814Google Scholar
  133. Porter J, Jick H (1977) Drug-related deaths among medical inpatients. JAMA 237:879–881PubMedGoogle Scholar
  134. Rinderknecht J, Shapiro L, Krauthammer M et al (1980) Accelerated clearance of small solutes from the lungs in interstitial lung disease. Am Rev Respir Dis 121:105–117PubMedGoogle Scholar
  135. Ross DJ, Waters PF, Waxman AD et al (1993) Regional distribution of lung perfusion and ventilation at rest and during steady-state exercise after unilateral lung transplantation. Chest 104:130–134PubMedGoogle Scholar
  136. Rosso J, Guillon JM, Parrot A et al (1992) Technetium-99m-DTPA aerosol and gallium-67 scanning in pulmonary complications of human immunodeficiency virus infection. J Nucl Med 33:91-87Google Scholar
  137. Royston D, Minty BD, Higenbottam TW et al (1985) The effect of surgery with cardiovascular bypass on alveolar-capillary barrier function in human being. Ann Thorac Surg 40:139–142PubMedGoogle Scholar
  138. Sackner MA (1978) Effects of respiratory drugs on mucociliary clearance. Chest 73 [Suppl]:958–964PubMedGoogle Scholar
  139. Sackner MA, Rosen MJ, Wanner A (1973) Estimation of tracheal mucous velocity by bronchofiberscopy. J Appl Physiol 34:495–499PubMedGoogle Scholar
  140. Sakakura Y, Proctor DF (1972) The effect of various conditions on tracheal mucociliary transport in dogs. Proc Soc Exp Biol Med 140:870–879PubMedGoogle Scholar
  141. Senden TJ, Moock KH, Gerald JF et al (1997) The physical and chemical nature of technegas. J Nucl Med 38:1327–1333PubMedGoogle Scholar
  142. Severinghaus JW, Swenson EW, Finley TN et al (1961) Unilateral hypoventilation produced in dogs by occluding one pulmonary artery. J Appl Physiol 16:53–60PubMedGoogle Scholar
  143. Shih WJ, Bognar B (1999) Reverse mismatched ventilation-perfusion pulmonary imaging with accumulation of technetium-99m-DTPA in a mucus plug in a main bronchus: a case report. J Nucl Med Technol 27:303–305PubMedGoogle Scholar
  144. Slavin JD Jr, Mathews J, Spencer RP (1985) Pulmonary ventilation/perfusion and reverse mismatches in an infant. Clin Nucl Med 10:708–709PubMedGoogle Scholar
  145. Sleigh MA (1977) The nature and action of respiratory tract cilia. In: Brain JD, Proctor DF, Reid LM (eds) Respiratory defense mechanisms, part 1. Dekker, New York, pp 247–288Google Scholar
  146. Sostman HD, Gottschalk A (1982) The stripe sign: a new diagnostic sign for diagnosis of nonembolic defects on pulmonary perfusion scintigraphy. Radiology 142:737–741PubMedGoogle Scholar
  147. Sostman HD, Gottschalk A (1992) Prospective validations of the stripe sign in ventilation-perfusion scintigraphy. Radiology 184:455–459PubMedGoogle Scholar
  148. Sprague RS, Thiemermann C, Vane JR (1992) Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits. Proc Natl Acad Sci USA 89:8711–8715PubMedGoogle Scholar
  149. Staub NC (1963) Site of action of hypoxia on the pulmonary vasculature. Fed Proc 22:453Google Scholar
  150. Staub NC (1983) Alveolar flooding and clearance. Am Rev Respir Dis 127:S44–S61PubMedGoogle Scholar
  151. Sundram FX (1995) Clinical studies of alveolar-capillary permeability using technetium-99m DTPA aerosol. Ann Nucl Med 9:171–178PubMedGoogle Scholar
  152. Susskind H, Brill AB, Harold WH (1986) Quantitative comparison of regional distributions of inhaled Tc-99m DTPA aerosol and Kr-81m gas in coal miners’ lungs. Am J Physiol Imaging 1:67–76PubMedGoogle Scholar
  153. Susskind H, Weber DA, Volkow ND et al (1991) Increased lung permeability following long-term use of free-base cocaine (crack). Chest 100:903–909PubMedGoogle Scholar
  154. Sutherland PW, Katsura T, Milic-Emili J (1968) Previous volume history of the lung and regional distribution of gas. J Appl Physiol 25:566–574PubMedGoogle Scholar
  155. Swenson EW, Finley TN, Guzman SV (1961) Unilateral hy-poventilation in man during temporary occlusion of one pulmonary artery. J Clin Invest 40:828–835PubMedGoogle Scholar
  156. Symington IS, Stack BHR (1977) Pulmonary thromboembolism after air travel. Br I Chest 17:138–140Google Scholar
  157. Taillefer R, Therasse E, Turpin S et al (1999) Comparison of early and delayed scintigraphy with 99m-apcitide and correlation with contrast-enhanced venography in detection of acute deep vein thrombosis. J Nucl Med 40:2029–2035PubMedGoogle Scholar
  158. Taplin GV, Isawa T (1968) Regional alveolar liquid diffusibility by lung scintigraphy. California University, Los Angeles, report UCLA 26-686, UC-48, biology and medicine, pp 4–48Google Scholar
  159. Taplin GV, Poe ND (1965) A dual lung scanning technique for evaluation of pulmonary function. Radiology 85:365–368PubMedGoogle Scholar
  160. Taylor AE, Gaar K (1970) Estimation of equivalent pore radii of pulmonary capillary and alveolar membranes. Am J Physiol 218:1133–1140PubMedGoogle Scholar
  161. Teshima T, Isawa T, Hirano T et al (1989) Image processing for mucociliary transport system. Respiration 8:828–835Google Scholar
  162. Thomas D, Stein M, Tanabe G et al (1964) Mechanisms of bronchoconstriction produced by thromboemboli in dogs. Am J Physiol 206:1207–1212PubMedGoogle Scholar
  163. UPET Investigators (1973) The urokinase pulmonary embolism trial. A national cooperative study. Circulation 47[Suppl 2]:46–50Google Scholar
  164. Van As A (1974) The role of selective beta 2-adrenoreceptor stimulants in the control of ciliary activity. Respiration 31:146–151PubMedGoogle Scholar
  165. Van der Wall H, Murray IPC, Jones PD et al (1991) Optimising technetium 99m diethylene triamine pentaacetate lung clearance in patients with the acquired immunodeficiency syndrome. Eur J Nucl Med 18:235–240PubMedGoogle Scholar
  166. Venrath H, Rothoff S, Valentin H et al (1952) Bronchospiro-metrische Untersuchungen bei Durchblutungsstoerungen in kleinen Kreislauf. Beitr Klinik Tuberk 107:291–294Google Scholar
  167. Wanner A (1977) Clinical aspects of mucociliary transport. Am Rev Respir Dis 116:73–125PubMedGoogle Scholar
  168. Wanner A (1981) Alteration of tracheal mucociliary transport in airway disease. Effect of pharmacologic agents. Chest 80 [Suppl]:867–870PubMedGoogle Scholar
  169. Wartski M, Zerbib E, Regnard JF et al (1998) Reverse ventilation-perfusion mismatch in lung cancer suggests intrapulmonary functional shunting. J Nucl Med 39:1986–1989PubMedGoogle Scholar
  170. Wartski M, Collignon MA for the THESE Study group (2000) Incomplete recovery of lung perfusion after 3 months in patients with acute pulmonary embolism treated with antiembolic agents. J Nucl Med 41:1043–1048PubMedGoogle Scholar
  171. Weibel ER (1963) Morphometry of the lung. Academic, New York, pp 1–151Google Scholar
  172. West JB (1965) Inequality of blood flow and ventilation in the normal lung. In: Ventilation/blood flow and gas exchange. Blackwell Scientific, Oxford, pp 17–33Google Scholar
  173. West JB, Dollery CT, Naimark A (1964) Distribution of blood flow in isolated lung; relation to vascular and alveolar pressure. J Appl Physiol 19:713–724PubMedGoogle Scholar
  174. Westbrook KC, Williams GD Jr, Wise WS et al (1969) Effects of acute hypoxia in dogs with an antegrade versus retrograde pulmonary blood flow. Surg Forum 20:217PubMedGoogle Scholar
  175. Whittenberger JL, McGregor M, Berglund E et al (1960) Influence of state of inflation of the lung on pulmonary vasculature. J Appl Physiol 15:878–882PubMedGoogle Scholar
  176. Windheim KV (1970) Perfusionsszintigraphische Untersuchungen der Lunge bei Bronchiektasien. Pneumonologie 143:193–196Google Scholar
  177. Wollmer P, Evander E, Jonson B et al (1986) Pulmonary clearance of inhaled 99mTc-DTPA: effect of surfactant depletion in rabbits. Clin Physiol 6:85–89PubMedGoogle Scholar
  178. Worsley DF, Alavi A (1995) Comprehensive analysis of the results of the PIOPED diagnosis. J Nucl Med 36:2380–2387PubMedGoogle Scholar
  179. Zielenski J, Tsui LC (1995) Cystic fibrosis: genotypic and phenotypic variations. Annu Rev Genet 29:777–807PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Toyoharu Isawa

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