Sorafenib: Targeting Multiple Tyrosine Kinases in Cancer

  • Jens HasskarlEmail author
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 201)


Sorafenib (BAY 43-9006, Nexavar®) is an oral multiple tyrosine kinase inhibitor. Main targets are receptor tyrosine kinase pathways frequently deregulated in cancer such as the Raf–Ras pathway, vascular endothelial growth factor (VEGF) pathway, and FMS-like tyrosine kinase 3 (FLT3). Sorafenib was approved by the FDA in fast track for advanced renal cell cancer and hepatocellular cancer and shows good clinical activity in thyroid cancer. Multiple clinical trials are undertaken to further investigate the role of sorafenib alone or in combination for the treatment of various tumor entities.


Thyroid Cancer Vascular Endothelial Growth Factor Receptor Acute Myelogenous Leukemia Renal Cell Cancer Differentiate Thyroid Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department Innere Medizin, Klinik für Innere Medizin ISchwerpunkt Hämatologie, Onkologie und StammzelltransplantationFreiburgGermany

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