Clinical Ophthalmic Oncology pp 189-200 | Cite as
Uveal Malignant Melanoma – Management Options: Proton Beam Radiotherapy
Chapter
First Online:
Abstract
Radiotherapy (RT) is the standard of care for the vast majority of malignant melanomas of the uveal tract. Eye conservation and, in many cases, maintenance of useful vision are possible.
Keywords
Optic Nerve Uveal Melanoma Proton Therapy Proton Irradiation Neovascular Glaucoma
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
- 1.Nag S, Quivey JM, Earle JD, Followill D. The American Brachytherapy Society recommendations for brachytherapy of uveal melanomas. Int J Radiat Oncol Biol Phys. 2003;56(2):544–55.PubMedCrossRefGoogle Scholar
- 2.Gragoudas ES, Goitein M, Koehler A, et al. Proton irradiation of choroidal melanomas: preliminary results. Arch Ophthalmol. 1978;96(9):1583–91.CrossRefGoogle Scholar
- 3.Char DH, Kroll SM, Castro J. Ten-year follow-up of helium ion therapy for uveal melanoma. Am J Ophthalmol. 1998;125(1):81–9.PubMedCrossRefGoogle Scholar
- 4.Seddon JM, Gragoudas ES, Egan KM, et al. Relative survival rates after alternative therapies for uveal melanoma. Ophthalmology. 1990;97(6):769–77.PubMedCrossRefGoogle Scholar
- 5.Puusaari I, Heikkonen J, Summanen P, Tarkkanen A, Kivelä T. Iodine brachytherapy as an alternative to enucleation for large uveal melanomas. Ophthalmology. 2003;110(11):2223–34.PubMedCrossRefGoogle Scholar
- 6.Diener-West M, Earle JD, Fine SL, et al. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma, III: initial mortality findings. COMS Report No. 18. Arch Ophthalmol. 2001;119(7):969–82.PubMedCrossRefGoogle Scholar
- 7.Gragoudas E, Goitein M, Seddon J, et al. Preliminary results of proton beam irradiation of macular and paramacular melanomas. Br J Ophthalmol. 1984;68(7):479–85.PubMedCentralPubMedCrossRefGoogle Scholar
- 8.Gragoudas ES, Goitein M, Verhey L, et al. Proton beam irradiation of uveal melanomas. Results of 5 1/2-year study. Arch Ophthalmol. 1982;100(6):928–34.PubMedCrossRefGoogle Scholar
- 9.Mueller AJ, Talies S, Schaller UC, Horstmann G, Wowra B, Kampik A. Stereotactic radiosurgery of large uveal melanomas with the gamma-knife. Ophthalmology. 2000;107(7):1381–7; discussion 87–8.PubMedCrossRefGoogle Scholar
- 10.Haas A, Pinter O, Papaefthymiou G, et al. Incidence of radiation retinopathy after high-dosage single-fraction gamma knife radiosurgery for choroidal melanoma. Ophthalmology. 2002;109(5):909–13.PubMedCrossRefGoogle Scholar
- 11.Suit HD, Goitein M, Tepper J, et al. Exploratory study of proton radiation therapy using large field techniques and fractionated dose schedules. Cancer. 1975;35(6):1646–57.PubMedCrossRefGoogle Scholar
- 12.Suit H. The Gray lecture 2001: coming technological advances in radiation oncology. Int J Radiat Oncol Biol Phys. 2002;53(4):798–809.PubMedCrossRefGoogle Scholar
- 13.Koehler A, Schneider R, Sisterson J. Range modulators for protons and heavy ions. Nucl Instrum Meth. 1975;131:437–40.CrossRefGoogle Scholar
- 14.Gragoudas ES. Charged particle irradiation of uveal melanoma. In: Ryan SJ, editor. Retina. 4th ed. Philadelphia: Mosby; 2006.Google Scholar
- 15.Goitein M, Miller T. Planning proton therapy of the eye. Med Phys. 1983;10(3):275–83.PubMedCrossRefGoogle Scholar
- 16.Gragoudas ES. Charged particle irradiation of uveal melanoma. In: Ryan SJ, editor. Retina. 3rd ed. St. Louis: Mosby; 2001.Google Scholar
- 17.Gragoudas ES, Goitein M, Koehler A, et al. Proton irradiation of malignant melanoma of the ciliary body. Br J Ophthalmol. 1979;63(2):135–9.PubMedCentralPubMedCrossRefGoogle Scholar
- 18.Gragoudas E, Goitein M, Verhey L, et al. Proton beam irradiation. An alternative to enucleation for intraocular melanomas. Ophthalmology. 1980;87(6):571–81.PubMedCrossRefGoogle Scholar
- 19.Gragoudas E, Seddon J, Egan K, et al. Long-term results of proton beam irradiated uveal melanomas. Ophthalmology. 1987;94(4):349–53.PubMedCrossRefGoogle Scholar
- 20.Gragoudas ES, Lane AM, Regan S, et al. A randomized controlled trial of varying radiation doses in the treatment of choroidal melanoma. Arch Ophthalmol. 2000;118(6):773–8.PubMedCrossRefGoogle Scholar
- 21.Egger E, Schalenbourg A, Zografos L, et al. Maximizing local tumor control and survival after proton beam radiotherapy of uveal melanoma. Int J Radiat Oncol Biol Phys. 2001;51(1):138–47.PubMedCrossRefGoogle Scholar
- 22.Damato B, Kacperek A, Chopra M, Campbell IR, Errington RD. Proton radiotherapy of choroidal melanoma: the Liverpool-Clatterbridge experience. Int J Radiat Oncol Biol Phys. 2005;62(5):1405–11.PubMedCrossRefGoogle Scholar
- 23.Dendale R, Lumbroso-Le Rouic L, Noel G, et al. Proton beam radiotherapy for uveal melanoma: results of Curie Institut-Orsay proton therapy center (ICPO). Int J Radiat Oncol Biol Phys. 2006;65(3):780–7.PubMedCrossRefGoogle Scholar
- 24.Gragoudas E, Li W, Goitein M, Lane AM, Munzenrider JE, Egan KM. Evidence-based estimates of outcome in patients irradiated for intraocular melanoma. Arch Ophthalmol. 2002;120(12):1665–71.PubMedCrossRefGoogle Scholar
- 25.Gragoudas E, Egan K, Seddon J, Walsh S, Munzenrider J. Intraocular recurrence of uveal melanoma after proton beam irradiation. Ophthalmology. 1992;99(5):760–6.PubMedCrossRefGoogle Scholar
- 26.Marucci L, Lane AM, Li W, et al. Conservation treatment of the eye: Conformal proton reirradiation for recurrent uveal melanoma. Int J Radiat Oncol Biol Phys. 2006;64(4):1018–22.PubMedCrossRefGoogle Scholar
- 27.Harbour JW, Murray TG, Byrne SF, et al. Intraoperative echographic localization of iodine 125 episcleral radioactive plaques for posterior uveal melanoma. Retina. 1996;16(2):129–34.PubMedCrossRefGoogle Scholar
- 28.Lane AM, Kim IK, Gragoudas ES. Proton irradiation for peripapillary and parapapillary melanomas. Arch Ophthalmol. 2011;128(9):1127–30.CrossRefGoogle Scholar
- 29.Sagoo MS, Shields CL, Mashayekhi A, et al. Plaque radiotherapy for juxtapapillary choroidal melanoma overhanging the optic disc in 141 consecutive patients. Arch Ophthalmol. 2008;126(11):1515–22.PubMedCrossRefGoogle Scholar
- 30.Finger PT. Finger’s “slotted” eye plaque for radiation therapy: treatment of juxtapapillary and circumpapillary intraocular tumours. Br J Ophthalmol. 2007;91(7):891–4.PubMedCentralPubMedCrossRefGoogle Scholar
- 31.Sagoo MS, Shields CL, Mashayekhi A, et al. Plaque radiotherapy for choroidal melanoma encircling the optic disc (circumpapillary choroidal melanoma). Arch Ophthalmol. 2007;125(9):1202–9.PubMedCrossRefGoogle Scholar
- 32.Egan K, Ryan L, Gragoudas E. Survival implications of enucleation after definitive radiotherapy for choroidal melanoma: An example of regression on time-dependent covariates. Arch Ophthalmol. 1998;116(3):366–70.PubMedCrossRefGoogle Scholar
- 33.Egger E, Zografos L, Schalenbourg A, et al. Eye retention after proton beam radiotherapy for uveal melanoma. Int J Radiat Oncol Biol Phys. 2003;55(4):867–80.PubMedCrossRefGoogle Scholar
- 34.Fuss M, Loredo LN, Blacharski PA, Grove RI, Slater JD. Proton radiation therapy for medium and large choroidal melanoma: preservation of the eye and its functionality. Int J Radiat Oncol Biol Phys. 2001;49(4):1053–9.PubMedCrossRefGoogle Scholar
- 35.Saornil M, Egan K, Gragoudas E, Seddon J, Walsh S, Albert D. Histopathology of proton beam-irradiated vs enucleated uveal melanomas. Arch Ophthalmol. 1992;110(8):1112–8.PubMedCrossRefGoogle Scholar
- 36.Regan S, Egan KM, Hart L, Gragoudas ES. Color Doppler imaging of untreated and irradiated choroidal melanomas. Eur J Ophthalmol. 2001;11(2):150–5.PubMedGoogle Scholar
- 37.Seddon JM, Gragoudas ES, Polivogianis L, et al. Visual outcome after proton beam irradiation of uveal melanoma. Ophthalmology. 1986;93(5):666–74.PubMedCrossRefGoogle Scholar
- 38.Seddon JM, Gragoudas ES, Egan KM, et al. Uveal melanomas near the optic disc or fovea. Visual results after proton beam irradiation. Ophthalmology. 1987;94(4):354–61.PubMedCrossRefGoogle Scholar
- 39.Gragoudas ES, Li W, Lane AM, Munzenrider J, Egan KM. Risk factors for radiation maculopathy and papillopathy after intraocular irradiation. Ophthalmology. 1999;106(8):1571–8.PubMedCrossRefGoogle Scholar
- 40.Gragoudas ES, Lane AM. Uveal melanoma: proton beam irradiation. Ophthalmol Clin North Am. 2005;18(1):111–8.PubMedCrossRefGoogle Scholar
- 41.Foss AJ, Whelehan I, Hungerford JL, et al. Predictive factors for the development of rubeosis following proton beam radiotherapy for uveal melanoma. Br J Ophthalmol. 1997;81(9):748–54.PubMedCentralPubMedCrossRefGoogle Scholar
- 42.Gragoudas ES, Egan KM, Walsh SM, Regan S, Munzenrider JE, Taratuta V. Lens changes after proton beam irradiation for uveal melanoma. Am J Ophthalmol. 1995;119(2):157–64.PubMedGoogle Scholar
- 43.Gragoudas ES. Charged particle irradiation of uveal melanoma. In: Ryan SJ, editor. Retina. 5th ed. London: Mosby; 2013.Google Scholar
- 44.Kim IK, Lane AM, Egan KM, Munzenrider J, Gragoudas ES. Natural history of radiation papillopathy after proton beam irradiation of parapapillary melanoma. Ophthalmology. 2010;117(8):1617–22.PubMedCrossRefGoogle Scholar
- 45.Courdi A, Caujolle JP, Grange JD, et al. Results of proton therapy of uveal melanomas treated in Nice. Int J Radiat Oncol Biol Phys. 1999;45(1):5–11.PubMedCrossRefGoogle Scholar
- 46.Kodjikian L, Roy P, Rouberol F, et al. Survival after proton-beam irradiation of uveal melanomas. Am J Ophthalmol. 2004;137(6):1002–10.PubMedCrossRefGoogle Scholar
- 47.Kim IK, Lane AM, Gragoudas ES. Survival in patients with presymptomatic diagnosis of metastatic uveal melanoma. Arch Ophthalmol. 2010;128(7):871–5.PubMedCrossRefGoogle Scholar
- 48.Gragoudas E, Egan K, Seddon J, et al. Survival of patients with metastases from uveal melanoma. Ophthalmology. 1991;98(3):383–90.PubMedCrossRefGoogle Scholar
- 49.Bedikian AY, Legha SS, Mavligit G, et al. Treatment of uveal melanoma metastatic to the liver: a review of the MD Anderson Cancer Center experience and prognostic factors. Cancer. 1995;76(9):1665–70.PubMedCrossRefGoogle Scholar
- 50.Eskelin S, Pyrhonen S, Hahka-Kemppinen M, Tuomaala S, Kivela T. A prognostic model and staging for metastatic uveal melanoma. Cancer. 2003;97(2):465–75.PubMedCrossRefGoogle Scholar
- 51.Flaherty LE, Unger JM, Liu PY, Mertens WC, Sondak VK. Metastatic melanoma from intraocular primary tumors: the Southwest Oncology Group experience in phase II advanced melanoma clinical trials. Am J Clin Oncol. 1998;21(6):568–72.PubMedCrossRefGoogle Scholar
- 52.Alexander Jr HR, Libutti SK, Pingpank JF, et al. Hyperthermic isolated hepatic perfusion using melphalan for patients with ocular melanoma metastatic to liver. Clin Cancer Res. 2003;9(17):6343–9.PubMedGoogle Scholar
- 53.Agarwala SS, Panikkar R, Kirkwood JM. Phase I/II randomized trial of intrahepatic arterial infusion chemotherapy with cisplatin and chemoembolization with cisplatin and polyvinyl sponge in patients with ocular melanoma metastatic to the liver. Melanoma Res. 2004;14(3):217–22.PubMedCrossRefGoogle Scholar
- 54.Aoyama T, Mastrangelo MJ, Berd D, et al. Protracted survival after resection of metastatic uveal melanoma. Cancer. 2000;89(7):1561–8.PubMedCrossRefGoogle Scholar
- 55.Hsueh EC, Essner R, Foshag LJ, Ye X, Wang HJ, Morton DL. Prolonged survival after complete resection of metastases from intraocular melanoma. Cancer. 2004;100(1):122–9.PubMedCrossRefGoogle Scholar
- 56.Shields CL, Demirci H, Marr BP, et al. Intravitreal triamcinolone acetonide for acute radiation papillopathy. Retina. 2006;26(5):537–44.PubMedCrossRefGoogle Scholar
- 57.Finger PT. Anti-VEGF bevacizumab (Avastin) for radiation optic neuropathy. Am J Ophthalmol. 2007;143(2):335–8.PubMedCrossRefGoogle Scholar
- 58.Finger PT, Chin K. Anti-vascular endothelial growth factor bevacizumab (Avastin) for radiation retinopathy. Arch Ophthalmol. 2007;125(6):751–6.PubMedCrossRefGoogle Scholar
- 59.Lane AM, Egan KM, Harmon D, et al. Adjuvant interferon therapy for patients with uveal melanoma at high risk of metastasis. Ophthalmology. 2009;116(11):2206–12.PubMedCrossRefGoogle Scholar
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