• Itaru KojimaEmail author
  • Masahiro Nagasawa
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 222)


Transient receptor potential vanilloid type 2, TRPV2, is a calcium-permeable cation channel belonging to the TRPV channel family. This channel is activated by heat (>52 °C), various ligands, and mechanical stresses. In most of the cells, a large portion of TRPV2 is located in the endoplasmic reticulum under unstimulated conditions. Upon stimulation of the cells with phosphatidylinositol 3-kinase-activating ligands, TRPV2 is translocated to the plasma membrane and functions as a cation channel. Mechanical stress may also induce translocation of TRPV2 to the plasma membrane. The expression of TRPV2 is high in some types of cells including neurons, neuroendocrine cells, immune cells involved in innate immunity, and certain types of cancer cells. TRPV2 may modulate various cellular functions in these cells.


Calcium Calcium-permeable channel Translocation Trafficking Mechanosensitive channel Stretch-activated channel 



The authors are grateful to Mayumi Odagiri for excellent secretarial assistance during the preparation of this manuscript.


  1. Anderson KE, Gratzke C, Hedlund P (2010) The role of the transient receptor potential (TRP) superfamily of cation-selective channels in the management of the overactive bladder. BJU Int 1063:1114–1127CrossRefGoogle Scholar
  2. Aoyagi K, Ohara-Imaizumi M, Nishiwaki C, Nakamichi Y, Nagamatsu S (2010) Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic β-cells. Biochem J 432:375–386PubMedCrossRefGoogle Scholar
  3. Bang S, Kim KY, Yoo S, Lee SH, Hwang SW (2007) Transient receptor potential V2 expressed in sensory neurons is activated by probenecid. Neurosci Lett 425:120–125PubMedCrossRefGoogle Scholar
  4. Barnhill JC, Stoeks AJ, Koblan-Huberson M, Shimoda LMN, Muraguchi A, Adra CN, Turner H (2004) RGA protein associates with a TRPV ion channel during biosynthesis and trafficking. J Cell Biochem 94:808–820CrossRefGoogle Scholar
  5. Benham CD, Gunthope MJ, Davis JB (2003) TRPV channels as temperature sensors. Cell Calcium 33:479–487PubMedCrossRefGoogle Scholar
  6. Boels K, Glassmeier G, Herrmann D, Riedel IB, Hampe W, Kojima I, Schwarz JR, Schaller HC (2001) The neuropeptide head activator induces activation and translocation of the growth factor-regulated Ca2+-permeable channel GRC. J Cell Sci 114:3599–3606PubMedGoogle Scholar
  7. Boyd RS, Jukes-Jones R, Walewska R, Brown D, Dyer MJ, Cain K (2009) Protein profiling of plasma membrane defines aberrant signaling pathways in mantle cell lymphoma. Mol Cell Proteomics 8:1501–1515PubMedCentralPubMedCrossRefGoogle Scholar
  8. Bubien JK, Zhou LJ, Bell PD, Frizzell RA, Tedder TF (1993) Transfection of CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. J Cell Biol 121:1121–1132PubMedCrossRefGoogle Scholar
  9. Burckhardt BC, Burckhardt G (2003) Transport of organic anions across the basolateral membrane of proximal tubular cells. Rev Physiol Biochem Pharmacol 146:95–158PubMedCrossRefGoogle Scholar
  10. Cahalan MD, Chandy KG (2009) The functional network of ion channels in T lymphocytes. Immunol Rev 231:59–87PubMedCentralPubMedCrossRefGoogle Scholar
  11. Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS, Xing Y, Lubischer JL, Kreig PA, Krupenko SA, Thompson WJ, Barres BA (2008) A transcriptome database for astrocytes, neuron, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci 28:264–278PubMedCrossRefGoogle Scholar
  12. Caprodossi S, Lucciarini R, Amantini C, Nabbisi M, Canesin G, Ballarini P, Di Spilimbergo A, Cardarelli MS, Servi L, Mammana G, Santoni G (2008) Transient receptor potential vanilloid type 2 (TRPV2) expression in normal urothelium and urothelial carcinoma of human bladder: correlation with the pathologic state. Eur Urol 54:612–620PubMedCrossRefGoogle Scholar
  13. Caterina MJ (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306–313PubMedCrossRefGoogle Scholar
  14. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816–824PubMedCrossRefGoogle Scholar
  15. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (1999) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398:435–441Google Scholar
  16. Cavanaugh DJ, Chesler AT, Jacjson AC, Sigal YM, Yamanaka H, Grant R, O’Donnell O, Nicholl RA, Shah NM, Julius D, Basbaum Al (2011) Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci 31:5067–5077Google Scholar
  17. Cha SK, Ortega B, Kurosu H, Rosenblatt KP, Kuro-O M, Huang CL (2008) Removal of sialic acid involving klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci USA 105:9805–9810PubMedCentralPubMedCrossRefGoogle Scholar
  18. Chang Q, Heef S, Vander Kemp AW, Tepala CN, Bindel RJ, Hoenderop JG (2005) The β-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310:490–493PubMedCrossRefGoogle Scholar
  19. Cheng W, Yang F, Takanishi CL, Zheng J (2007) Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties. J Gen Physiol 129:191–207PubMedCentralPubMedCrossRefGoogle Scholar
  20. Colbert HA, Smith TL, Bargmann CI (1997) OSM-9, a novel protein with structural similarity to channel, is required for olfaction, mechanosensation and olfactory adaptation in Caenorhabditis elegans. J Neurosci 17:8259–8269PubMedGoogle Scholar
  21. Cordeiro S, Seyler S, Stindl J, Milenkovic VM, Strauss O (2010) Heat-sensitive TRPV channels in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 51:6001–6008PubMedCrossRefGoogle Scholar
  22. Cushman SV, Wardzala LJ (1980) Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. J Biol Chem 255:4758–4762PubMedGoogle Scholar
  23. De Petrocellis L, Ligresti A, Moriello AS, Allara M, Bisogno T, Petrosino S, Stott CG, Di Marzo V (2011) Effects of cannabinoids and cannabinoid-enriched cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Br J Pharmacol 163:1479–1494PubMedCentralPubMedCrossRefGoogle Scholar
  24. Dietrich A, Chubanov V, Kalwa H, Rost BR, Gudermann T (2006) Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells. Pharmacol Ther 112:744–760PubMedCrossRefGoogle Scholar
  25. Dobrydneva Y, Blackmore P (2001) 2-Animoethoxydiphenyl borate directly inhibits store-operated calcium entry channels in human platelets. Mol Pharmacol 60:541–552PubMedGoogle Scholar
  26. Everaerts W, Vriens J, Owsianik G, Appendino G, Voets T, Ridder DD, Nillius B (2009) Functional characterization of transient receptor potential channels in mouse urothelial cells. Am J Physiol 298:F692–F701Google Scholar
  27. Fanntozzi I, Zhang S, Platoshyn O, Remillard CV, Cowling RT, Yuan JXJ (2003) Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 285:L1233–L1245Google Scholar
  28. Gao X, Wu L, O’Neil RG (2003) Temperature-modulated diversity of TRPV4 channel gating: activator by physical stresses and phorbol ester derivatives through protein kinase C-dependent and independent pathways. J Biol Chem 278:27129–27137PubMedCrossRefGoogle Scholar
  29. Garicia-Sanz N, Fernandez-Carvajar A, Morenilla-Parao C, Planells-Case R, Fajardo-Sanchez E, Fernandez-Ballester G, Ferrer-Montiel A (2004) Identification of a tetramerization domain in the C-terminus of the vanilloid receptor. J Neurosci 24:5307–5314CrossRefGoogle Scholar
  30. Gibbs JC, Melnyk JL, Basbaum AI (2011) Differential TRPV1 and TRPV2 channel expression in dental pulp. J Dent Res 90:765–770PubMedCentralPubMedCrossRefGoogle Scholar
  31. Gkika D, Prevarskaya N (2011) TRP channels in prostate cancer: the good, the bad and the ugly? Asian J Androl 13:673–676PubMedCentralPubMedCrossRefGoogle Scholar
  32. Hamamoto Y, Takumida M, Hirakuwa K, Tatsukawa T, Ishibashi T (2008) Localization of transient receptor potential vanilloid (TRPV) in the human larynx. Acta Otolaryngol 129:495–507Google Scholar
  33. Heiner I, Eisfeld J, Luckholl A (2003) Role and regulation of TRP channels in neutrophil granulocytes. Cell Calcium 33:533–540PubMedCrossRefGoogle Scholar
  34. Hellwig N, Albrecht N, Harteneck C, Schultz G, Schaefer M (2005) Homo- and heteromeric assembly of TRPV channel subunits. J Cell Sci 118:918–928CrossRefGoogle Scholar
  35. Hisanaga E, Nagasawa M, Ueki K, Kuikarni R, Mori M, Kojima I (2009) Regulation of calcium-permeable channel TRPV2 by insulin in pancreatic β-cells. Diabetes 58:174–184PubMedCentralPubMedCrossRefGoogle Scholar
  36. Holakovska B, Grycova L, Bily J, Teisinger J (2011) Characterization of calmodulin-binding domains in TRPV2 and TRPV5 C-tails. Amino Acids 40:741–748PubMedCrossRefGoogle Scholar
  37. Hu HZ, Gu Q, Wang C, Colton CK, Tang J, Kinoshita-Kowada M, Lee LY, Wood JD, Zhu MX (2004) 2-Aminoethyldiphenyl borate is a common activator of TRPV1, TRPV2 and TRPV3. J Biol Chem 279:35741–35748PubMedCrossRefGoogle Scholar
  38. Ichikawa H, Sugimoto T (2001) VR1-immunoreactive primary sensory neurons in the rat trigeminal ganglion. Brain Res 890:184–188PubMedCrossRefGoogle Scholar
  39. Ignatowska-Jankowska B, Jankowski M, Glac W, Swiergel AH (2009) Cannabidiol-induced lymphopenia does not involve NKT and NK cells. J Physiol Pharmacol 60:99–103PubMedGoogle Scholar
  40. Inoue R, Jensen LJ, Morita H, Nishida M, Honda A, Ito Y (2006) Transient receptor potential channels in cardiovascular function and disease. Circ Res 99:119–131PubMedCrossRefGoogle Scholar
  41. Iwata Y, Katanosaka Y, Arai Y, Komamura K, Miyatake K, Shigekawa M (2003) A novel mechanism of myocyte degeneration involving the Ca2+-permeable growth factor-regulated channel. J Cell Biol 161:957–967PubMedCentralPubMedCrossRefGoogle Scholar
  42. Iwata Y, Katanosaka Y, Arai Y, Shigekawa M, Wakabayashi S (2009) Dominant-negative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal model. Hum Mol Genet 18:824–834PubMedGoogle Scholar
  43. Jahnel R, Bender O, Munber LM, Dreger M, Gillen C, Hucho F (2003) Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F11 and biochemical analysis of VRL-1 after heterologous expression. Eur J Biochem 270:4264–4271PubMedCrossRefGoogle Scholar
  44. Jin X, Touhey J, Gaudet R (2006) Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel. J Biol Chem 281:25006–25010PubMedCrossRefGoogle Scholar
  45. Juvin V, Penna A, Chemin J, Lin YL, Rassedren FA (2007) Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate. Mol Pharmacol 72:1250–1268CrossRefGoogle Scholar
  46. Kajiya H, Okamoto F, Nemoto T, Kimachi K, Toh-goto K, Nakayama S, Okabe K (2010) RANKL-induced TRPV2 expression regulates osteoclastogenesis via calcium oscillation. Cell Calcium 48:260–269PubMedCrossRefGoogle Scholar
  47. Kanzaki M, Nie L, Shibata H, Kojima I (1997) Activation of a calcium-permeable channel CD20 expressed in Balb/c 3T3 cells by insulin-like growth factor-I. J Biol Chem 272:2964–2969CrossRefGoogle Scholar
  48. Kanzaki M, Zhang YQ, Mashima H, Li L, Shibata H, Kojima I (1999) Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I. Nat Cell Biol 1:165–170PubMedCrossRefGoogle Scholar
  49. Kashiba H, Uchida Y, Takada D, Nishigori A, Ueda Y, Kuribayashi K, Ohshima M (2004) TRPV2-immunoreactive intrinsic neurons in the rat intestine. Neurosci Lett 366:193–196PubMedCrossRefGoogle Scholar
  50. Kim J, Chung YD, Park DY, Choi S, Shin DW, Soh H, Lee HW, Son W, Yim J, Park CS, Kernan MJ, Kim C (2003) A TRPV family ion channel required for hearing in Drosophila. Nature 424:81–84PubMedCrossRefGoogle Scholar
  51. Kippenberger S, Loitch S, Guschel M, Muller J, Knies Y, Kaufman R, Bernd A (2005) Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor. J Biol Chem 280:3060–3067PubMedCrossRefGoogle Scholar
  52. Koch SE, Gao XQ, Haar L, Jiang M, Lasko VM, Robbins N, Cai W, Brokamp C, Varma P, Tranter M, Liu Y, Ren XP, Lorenz JN, Wang HS, Jones WK, Rubinstein J (2012) Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol 53:134–144PubMedCentralPubMedCrossRefGoogle Scholar
  53. Koga T, Inui M, Inoue K, Kim S, Suematsu A, Kobayashi E, Iwata T, Ohnishi H, Matozaki T, Kodama T, Taniguchi T, Takayanagi H, Takai T (2004) Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 428:758–763PubMedCrossRefGoogle Scholar
  54. Koike S, Uno T, Bamba H, Shibata T, Okano H, Hisa Y (2004) Distribution of vanilloid receptors in the rat laryngeal innervation. Acta Otolaryngol 124:515–519PubMedCrossRefGoogle Scholar
  55. Kojima I, Nagasawa M (2007) TRPV2: a calcium-permeable cation channel regulated by insulin-like growth factor. In: Liedtke WB, Heller S (eds) TPP ion channel function in sensory transduction and cellular signaling cascade. CRC, Boca Raton, FLGoogle Scholar
  56. Kojima I, Matsunaga H, Kurokawa K, Ogata E, Nishimoto I (1988) Calcium influx: an intracellular message of the mitogenic action of insulin-like growth factor-I. J Biol Chem 263:16561–16567PubMedGoogle Scholar
  57. Kojima I, Mogami H, Shibata H, Ogata E (1993) Role of calcium entry and protein kinase C in the progression activity of insulin-like growth factor-I. J Biol Chem 268:10003–10006PubMedGoogle Scholar
  58. Komatsu H, Kojima M, Tsutsumi N, Hamano S, Kusama H, Ujiie A, Ikeda S, Nakazawa M (1988) Mechanism of inhibitory action of tranilast on the release of SRS-A in vitro. Jpn J Pharmacol 46:53–60PubMedCrossRefGoogle Scholar
  59. Kowase T, Nakazato Y, Yoko-o H, Morikawa A, kojima I (2003) Immunohistochemical localization of growth factor-regulated channel (GRC) in human tissues. Endocr J 49:349–355CrossRefGoogle Scholar
  60. Leffler A, Linte RM, Nau C, Reeh P, Babes A (2007) A high-threshold heat-activated channels in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadrinium. Eur J Neurosci 26:12–22PubMedCrossRefGoogle Scholar
  61. Lehen’kyi V, Prevarskaya N (2012) TRPV2 (transient receptor potential cation channel, subfamily v, member 2). Atlas Cenet Cytogenet Oncol Haematol 16:563–567Google Scholar
  62. Lenonnier L, Pravarskay N, Mazurier J, Shuba Y, Skryma R (2004) 2-APB inhibits volume-regulated anion channels independently from intracellular calcium signaling modulation. FEBS Lett 566:121–126CrossRefGoogle Scholar
  63. Lewinter RD, Skinner K, Julius D, Basbaum AI (2004) Immunoreactive TRPV2, a capsaicin receptor homolog, in the spinal cord of the rat. J Comp Neurol 470:400–408PubMedCrossRefGoogle Scholar
  64. Liapi A, Wood JN (2005) Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. Eur J Neurosci 22:825–834PubMedCrossRefGoogle Scholar
  65. Lin Y, Sun Z (2012) Antiaging gene klotho enhances glucose-induced insulin secretion by up-regulating plasma-membrane levels of TRPV2 in MIN6 cells. Endocrinology 153:3029–3039PubMedCentralPubMedCrossRefGoogle Scholar
  66. Linder S, Apfelbacher M (2003) Podosomes: adhesion hot spot of invasive cells. Trends Cell Biol 13:376–385PubMedCrossRefGoogle Scholar
  67. Link TM, Park U, Vonakis BM, Raben DM, Soloski MJ, Caterina MJ (2010) TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat Immunol 11:232–239PubMedCentralPubMedCrossRefGoogle Scholar
  68. Lioudyno MI, Kozak JA, Penna A, Safrina O, Zhang SL, Sen D (2008) Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation. Proc Natl Acad Sci USA 105:2011–2016PubMedCentralPubMedCrossRefGoogle Scholar
  69. Lishko PV, Thyagarajan B, Lukas V (2007) The ankyrin repeats of TRPV1 binds multiple ligands and modulate channel activity. Neuron 54:905–918PubMedCrossRefGoogle Scholar
  70. Liu G, Xie C, Sun F, Xu X, Yang Y, Zhang T, Deng Y, Wang D, Huang Z, Yang L, Huang S, Wang Q, Liu G, Zhong D, Miao X (2010) Clinical significance of transient receptor potential vanilloid 2 expression in human hepatocellular carcinoma. Cancer Genet Cytogenet 197:54–59PubMedCrossRefGoogle Scholar
  71. Ma QP (2001) Vanilloid receptor homolog, VRL1, is expressed by both A- and C-fiber sensory neurons. Neuroreport 12:3693PubMedCrossRefGoogle Scholar
  72. Maruyama T, Kanaji T, Nakade S, Kanno T, Mikoshiba K (1997) 2APB, 2-aminoethoxydiphenyl borate, a membrane-permeable modulator of Ins (1, 4, 5)P3-induced Ca2+ release. J Biochem 122:498–505PubMedCrossRefGoogle Scholar
  73. McCleverty CJ, Koesema E, Patapoutian A, Lesley SA, Kreusch A (2006) Crystal structure of the human TRPV2 channel ankyrin repeat domain. Protein Sci 15:2201–2206PubMedCentralPubMedCrossRefGoogle Scholar
  74. Mercado J, Gordon-Shaag A, Zagotta WN, Gordon SE (2010) Ca2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4, 5-bisphosphate. J Neurosci 30:13338–13347PubMedCentralPubMedCrossRefGoogle Scholar
  75. Mihara H, Boudaka A, Shibasaki K, Yamanaka A, Sugiyama T, Tominaga M (2010) Involvement of TRPV2 activation in intestinal movement through nitric oxide production in mice. J Neurosci 30:16536–16544PubMedCrossRefGoogle Scholar
  76. Monet M, Gkika D, Lehen’kyi V, Pourties A, Abeele FV, Bidaux G, Juvin V, Rassendren F, Humez S, Pravaesakaya N (2009) Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta 1793:528–539PubMedCrossRefGoogle Scholar
  77. Monet M, Lehen’kyi V, Gackiere F, Firlej V, Vandenberghe M, Rassendren F, Roudbaraki M, Gkika D, Pourtier A, Bidaux G, Slomianny C, Humez S, Prevarsakaya N (2010) Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance. Cancer Res 70:1225–1235PubMedCrossRefGoogle Scholar
  78. Morelli MB, Nabissi M, Amantini C, Farfariello V, Ricci-vitiani L, Martino S, Pallini R, Laroca LM, Caprodossi S, Santoni M, Maria RD, Santoni G (2012) The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation. Int J Cancer 131:E1067–E1077PubMedCrossRefGoogle Scholar
  79. Muraki K, Iwata Y, Katanosaka Y, Ito T, Ohya S, Shigekawa M, Imaizumi Y (2003) TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ Res 93:829–838PubMedCrossRefGoogle Scholar
  80. Nabissi M, Morelli MB, Amantini C, Farfariello V, Ricci-Vitiani L, Caprodossi S, Arcella A, Santoni M, Giangaspero F, DeMaria R, Santoni G (2010) TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner. Carcinogenesis 31:794–803PubMedCrossRefGoogle Scholar
  81. Nabissi M, Morelli MB, Santoni M, Santoni G (2013) Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents. Carcinogenesis 34:48–57PubMedCrossRefGoogle Scholar
  82. Nagasawa M, Kojima I (2012) Translocation of calcium-permeable TRPV2 channel to the podosome: its role in the regulation of podosome assembly. Cell Calcium 51:186–193PubMedCrossRefGoogle Scholar
  83. Nagasawa M, Nakagawa Y, Tanaka S, Kojima I (2007) Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages. J Cell Physiol 210:692–702PubMedCrossRefGoogle Scholar
  84. Nedungadi TP, Dutta M, Mathina CS, Caterina MJ, Cunningham JT (2012a) Expression and distribution of TRPV2 in rat brain. Exp Neurol 237:223–237PubMedCentralPubMedCrossRefGoogle Scholar
  85. Nedungadi TP, Carreno FR, Walch JD, Bathina CS, Cunningham JT (2012b) Region-specific changes in transient receptor potential vanilloid channel expression in the vasopressin magnocellular system in hepatic-cirrhosis-induced hyponatremia. J Neuroendocrinol 24:624–652CrossRefGoogle Scholar
  86. Neeper MP, Liu Y, Hutchinson TL, Wang Y, Flores CM, Qin N (2007) Activation properties of heterologously expressed mammalian TRPV2: evidence of species difference. J Biol Chem 282:15894–15902PubMedCrossRefGoogle Scholar
  87. Negishi-Koga T, Takayanagi H (2009) Ca2+-NFATc signaling is an essential axis of osteoclast differentiation. Immunol Rev 231:241–256PubMedCrossRefGoogle Scholar
  88. Nie L, Mogami H, Kanzaki M, Shibata H, Kojima I (1996) Blockade of DNA synthesis induced by platelet-derived growth factor by tranilast, an inhibitor of calcium entry, in vascular smooth muscle cells. Mol Pharmacol 50:763–769PubMedGoogle Scholar
  89. Nie L, Oishi Y, Doi I, Shibata H, Kojima I (1997) Inhibition of proliferation of MCF-7 breast cancer cells by a blocker of Ca2+-permeable channel. Cell Calcium 22:75–82PubMedCrossRefGoogle Scholar
  90. Nilius B, Prenen J, Weissenbach U, Bodding M, Droogmans G (2001) Differential activation of the volume-sensitive cation channel TRPV2 (OTRPC4) and volume-regulated anion currents in HEK-293 cells. Pflugers Arch 443:227–233PubMedCrossRefGoogle Scholar
  91. Numazaki M, Tominaga T, Takeuchi K, Murayama K, Toyooka H, Tominaga M (2003) Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc Natl Acad Sci USA 100:8002–8006PubMedCentralPubMedCrossRefGoogle Scholar
  92. Odell AF, Scott JL, Helden DFV (2005) Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4. J Biol Chem 280:37974–37987PubMedCrossRefGoogle Scholar
  93. Park KS, Kim Y, Lee YH, Earm YE, Ho WK (2003) Mechanosensitive cation channel in arterial smooth muscle cells are activated by diacylglycerol and inhibited by phospholipase C inhibitor. Circ Res 93:557–564PubMedCrossRefGoogle Scholar
  94. Park KS, Pang B, Park S, Lee YG, Bae JY, Park S (2011a) Identification and functional characterization of ion channels in CD34(+) hematopoietic stem cells from human peripheral blood. Mol Cell 32:181–188CrossRefGoogle Scholar
  95. Park U, Vastani N, Guan Y, Raja SNM, Koltzenburg M, Caterina MJ (2011b) TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. J Neurosci 31:11425–11436PubMedCentralPubMedCrossRefGoogle Scholar
  96. Peng G, Lu W, Li X, Chen Y, Zhang N, Ran P, Wang J (2010) Expression of store-operated Ca2+ entry and transient receptor potential canonical and vanilloid-related proteins in rat distal pulmonary venous smooth muscle. Am J Physiol Lung Cell Mol Physiol 299:L621–L630PubMedCentralPubMedCrossRefGoogle Scholar
  97. Penna A, Juvin V, Chemin J, Compan V, Monet M, Rassendren FA (2006) PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane. Cell Calcium 39:495–507PubMedCrossRefGoogle Scholar
  98. Peppelenbosch MP, Tertoolen LG, Vrien-Smits AMM, Qiu RG, M’Rabet L, Symons MH, de Laat SW, Bos JL (1996) Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx. J Biol Chem 271:7883–7886PubMedCrossRefGoogle Scholar
  99. Phelps CB, Procko E, Lishko PV, Wang RR, Gaudet R (2007) Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels. Channels 1:148–151PubMedGoogle Scholar
  100. Phelps CB, Wang RR, Choo SS, Gaudet R (2010) Differential regulation of TRPV1, TRPV3 and TRPV4 sensitivity through a conserved biding site on the ankyrin repeat domain. J Biol Chem 285:731–740PubMedCentralPubMedCrossRefGoogle Scholar
  101. Qin N, Neeper MP, Liu Y, Huchinson TL, Lubin ML, Flores CM (2008) TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci 28:6231–6238PubMedCrossRefGoogle Scholar
  102. Robbin N, Koch SE, Tranter M, Rubinstein J (2012) The history and future of probenecid. Cardiovasc Toxicol 12:1–9CrossRefGoogle Scholar
  103. Rosenbaum T, Gordon-Shaag A, Munari M, Gordon SE (2004) Ca2+/calmodulin modulates TRPV1 activation by capsaicin. J Gen Physiol 123:53–62PubMedCentralPubMedCrossRefGoogle Scholar
  104. Rutter AR, Ma QP, Leveridge M, Bonnert TP (2005) Heteromerization and colocalization of TrpV1 and TrpV2 in mammalian cell lines and rat dorsal root ganglion. Neuroreport 16:1735–1739PubMedCrossRefGoogle Scholar
  105. Saito M, Hanson PI, Schlesinger P (2007) Luminal chloride-dependent activation of endosome calcium channels. J Biol Chem 282:27327–27333PubMedCrossRefGoogle Scholar
  106. Santoni G, Farfariello V, Liberati S, Morelli MB, Nabbisi M, Santoni M, Amantini C (2013) The role of transient receptor potential vanilloid type-2 ion channels in innate and adaptive immune systems. Front Immunol 4:1–9CrossRefGoogle Scholar
  107. Sato M, Sobban U, Tsumura M, Kuroda H, Soya M, Masamura A, Nishiyama A, Katakura A, Ichinohe T, Tazaki M, Shibukawa Y (2013) Hypotonic-induced stretching of plasma membrane activates transient receptor potential vanilloid channels and sodium-calcium exchangers in mouse odontoblasts. J Endod 39:779–787PubMedCrossRefGoogle Scholar
  108. Sauer K, Jegla TJ (2006) Methods for identifying T cell activation modulating compounds. Patent Application WO/2006/065613Google Scholar
  109. Saunders CI, Kunde DA, Crawford A, Geraghty DP (2007) Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood. Mol Immunol 44:1429–1435PubMedCrossRefGoogle Scholar
  110. Schwartz MA, Brown EJ, Fazeli B (1993) A 50-KDa integrin-associated protein is required for integrin-regulated calcium entry in endothelial cells. J Biol Chem 268:19931–19934PubMedGoogle Scholar
  111. Shibasaki K, Murayama N, Ono K, Ishizaki Y, Tominaga M (2010) TRPV enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons. J Neurosci 30:4601–4612PubMedCrossRefGoogle Scholar
  112. Shibata H, Omata W, Kojima I (1995) Dissection of GLUT4 recycling pathway into exocytosis and endocytosis in rat adipocytes. J Biol Chem 270:11489–11495PubMedCrossRefGoogle Scholar
  113. Shimohira D, Kido MA, Danjo A, Takao T, Wang B, Zhang JQ, Yamazaki T, Masuko S, Goto M, Tanaka T (2009) TRPV2 expression in rat oral mucosa. Histochem Cell Biol 132:423–433PubMedCrossRefGoogle Scholar
  114. Son AR, Yang YM, Hong JH, Lee SI, Shibukawa Y, Shin DM (2009) Odontoblast TRP channels and thermo/mechanical transmission. J Dent Res 88:1014–1019PubMedCrossRefGoogle Scholar
  115. Spinsanti G, Zannolli R, Panti C, Ceccarelli I, Mareili L, Bachicco V (2008) Quantitative real time PCR detection of TRPV-4 gene expression in human leukocytes from healthy and hyposensitive subjects. Mol Pain 4:51PubMedCentralPubMedCrossRefGoogle Scholar
  116. Stokes AJ, Shimoda IM, Koblan-Huberson M, Adra CN, Turner H (2004) TRPV2-PKA signaling module for transduction of physical stimuli in mast cells. J Exp Med 200:137–147PubMedCentralPubMedCrossRefGoogle Scholar
  117. Stokes AJ, Wakano C, Del Carmen KA, Koblan-Huberson M, Turner H (2005) Formation of a physiological complex between TRPV2 and RGA protein promotes cell surface expression of TRPV2. J Cell Biochem 94:669–683PubMedCrossRefGoogle Scholar
  118. Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D (2004) A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci USA 101:6062–6067PubMedCentralPubMedCrossRefGoogle Scholar
  119. Suzuki K, Kono T (1980) Evidence that insulin causes translocation of glucose transport activity to plasma membrane from an intracellular storage site. Proc Natl Acad Sci USA 77:2542–2545PubMedCentralPubMedCrossRefGoogle Scholar
  120. Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue K, Wagner EF, Mak TW, Kodama T, Taniguchi T (2002) Induction and activation of the transcription factor NFATc (NFAT2) integrate RANK signaling in terminal differentiation of osteoclasts. Dev Cell 3:889–901PubMedCrossRefGoogle Scholar
  121. Tominaga M, Caterina MJ (2004) Thermosensation and pain. J Neurobiol 61:3–12PubMedCrossRefGoogle Scholar
  122. Urrutia R, Henley JR, Cook T, McNiven MA (1997) The dynamins: redundant or distinct functions for an expanding family of related GTPases? Proc Natl Acad Sci USA 94:377–384PubMedCentralPubMedCrossRefGoogle Scholar
  123. Vriends J, Appendino G, Nilius B (2009) Pharmacology of vanilloid transient receptor potential cation channels. Mol Pharmacol 75:1262–1279CrossRefGoogle Scholar
  124. Vriens J, Janssens A, Prenen J, Nilius B, Wondergem R (2004) TRPV channels and modulation by hepatocyte growth factor in human hepatoblastoma (HepG2) cells. Cell Calcium 36:19–28PubMedCrossRefGoogle Scholar
  125. Wainszelbaum MJ, Proctor BM, Pountow SE, Stahl PD, Barbieri A (2006) IL4/PGE2 induction of an enlarged early endosomal compartment in mouse macrophages is Rab5-dependent. Exp Cell Res 312:2238–2251PubMedCrossRefGoogle Scholar
  126. Wirkner K, Hognestad H, Jahnel R, Hucho F, Illes P (2005) Characterization of rat transient potential vanilloid receptors lacking the N-glycosylation site N604. Neuroreport 16:947–1001CrossRefGoogle Scholar
  127. Xiao R, Xu XZ (2011) C. elegans TRP channels. Adv Exp Med Biol 704:323–339PubMedCentralPubMedCrossRefGoogle Scholar
  128. Yamada T, Ueda T, Shibata Y, Ikegami Y, Saito M, Ishida Y, Ugawa S, Kohri K, Shimada S (2010) TRPV2 activation induces apoptotic cell death in human T-24 bladder cancer cells: a potential therapeutic target for bladder cancer. Urology 76(509):e1–e17PubMedGoogle Scholar
  129. Yamamoto Y, Taniguchi K (2005) Immunolocalization of VR1 and VRL1 in rat larynx. Auton Neurosci 117:62–65PubMedCrossRefGoogle Scholar
  130. Yamashiro K, Sasano T, Tojo K, Namekata I, Kurokawa I, Sawada N (2010) Role of transient receptor potential vanilloid-2 in macrophages. Biochem Biophys Res Commun 398:284–289PubMedCrossRefGoogle Scholar
  131. Yao J, Liu B, Qin F (2011) Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels. Proc Natl Acad Sci USA 108:11109–11114PubMedCentralPubMedCrossRefGoogle Scholar
  132. Yu W, Hill WG, Apodaca G, Zeidel ML (2011) Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium. Am J Physiol Renal Physiol 300:F49–F59PubMedCentralPubMedCrossRefGoogle Scholar
  133. Zhang D, Spielman A, Wang L, Ding G, Huang F, Gu Q (2012) Mast cell degranulation induced by physical stimuli involves the activation of transient receptor potential channel TRPV2. Physiol Res 61:113–124PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Cell BiologyInstitute for Molecular & Cellular Regulation, Gunma UniversityMaebashiJapan

Personalised recommendations