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TRPV2

  • Itaru KojimaEmail author
  • Masahiro Nagasawa
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 222)

Abstract

Transient receptor potential vanilloid type 2, TRPV2, is a calcium-permeable cation channel belonging to the TRPV channel family. This channel is activated by heat (>52 °C), various ligands, and mechanical stresses. In most of the cells, a large portion of TRPV2 is located in the endoplasmic reticulum under unstimulated conditions. Upon stimulation of the cells with phosphatidylinositol 3-kinase-activating ligands, TRPV2 is translocated to the plasma membrane and functions as a cation channel. Mechanical stress may also induce translocation of TRPV2 to the plasma membrane. The expression of TRPV2 is high in some types of cells including neurons, neuroendocrine cells, immune cells involved in innate immunity, and certain types of cancer cells. TRPV2 may modulate various cellular functions in these cells.

Keywords

Calcium Calcium-permeable channel Translocation Trafficking Mechanosensitive channel Stretch-activated channel 

Notes

Acknowledgments

The authors are grateful to Mayumi Odagiri for excellent secretarial assistance during the preparation of this manuscript.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Cell BiologyInstitute for Molecular & Cellular Regulation, Gunma UniversityMaebashiJapan

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