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TRPs: Truly Remarkable Proteins

  • Veit Flockerzi
  • Bernd Nilius
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 222)

Abstract

The family of transient receptor potential cation channels has received in the last 10 years a tremendous interest because members of this family are involved in a plethora of cell functions and have been identified as causal for many hereditary and acquired diseases. We shortly introduce these channels, summarize nomenclature and chromosomal location of the 28 mammalian Trp genes, and list the available Trp-deficient mouse lines.

Keywords

TRP cation channel proteins TRP phylogenetic tree Trp gene Chromosomal location Trp gene knockout Trp-deficient mouse strain Mouse (animal) model 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des SaarlandesHomburgGermany
  2. 2.Laboratory Ion Channel Research, Department Cell Mol MedicineKU LeuvenLeuvenBelgium

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