Selenoneine in Marine Organisms

  • Michiaki YamashitaEmail author
  • Yumiko Yamashita
Part of the Springer Handbooks book series (SHB)


A novel selenium-containing compound, selenoneine, 2-selenyl- N α Open image in new window, N α Open image in new window, N α Open image in new window-trimethyl-l-histidine, has been identified as the predominant form of organic selenium in the blood and tissues of tuna. This selenium compound has a selenium atom in the imidazole ring, and is a selenium analog of a thiol compound, ergothioneine. Selenoneine has radical scavenging activity and exerts an antioxidant effect by binding to hemoglobin and myoglobin, protecting them from iron auto-oxidation. In addition, selenoneine has detoxifying activity against methylmercury (MeHg). Selenoneine has been found to be a specific substrate for the organic cation/carnitine transporter OCTN1 (solute carrier family 22 Open image in new window member 4 Open image in new window, SLC22A4), and mediated the excretion and demethylation of MeHg by exosomal small vesicle formation. The dietary intake of selenoneine through fish consumption is an important selenium source in the human diet. Since selenoneine and its related selenoproteins have strong antioxidant activities, disease protective functions, such as anticarcinogenesis and aging effects, may be expected.


Inductively Couple Plasma Mass Spectrometry Bluefin Tuna Inorganic Mercury Selenium Deficiency MeHg Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



deoxyribonucleic acid




endosomal sorting complexes required for transport


gel permeation chromatography


glutathione peroxidase




high-performance liquid chromatography


human umbilical vein endothelial cells


inductively coupled plasma mass spectrometry


ion concentration polarization


c-Jun N-terminal kinase


liquid chromatography


maslinic acid


morpholino antisense oligo


mass spectroscopy








normal hydrogen reference electrode


reactive oxygen species

SMase  1

sphingomyolinase 1




Selenocysteine-transfer RNA


complementary DNA


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Food Safety Assessment Research GroupNational Research Institute of Fisheries ScienceYokohamaJapan

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