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Morphologie und Biochemie des endokrinen Herzens

  • W. G. Forssmann
  • D. Hock
Conference paper

Zusammenfassung

Die ersten Beobachtungen, die darauf hinwiesen, daß das Herz eine endokrine Funktion besitzt, stammen aus dem Jahre 1956. In einer morphologisch-elektronenmikroskopischen Studie fand Kisch (22) in den atrialen Myokardiozyten beim Meerschweinchen runde, dunkle Einschlüsse mit unbekannter Funktion, die heute als Sekretgranula bekannt sind. Bompiani et al. (4) beschrieben die gleichen Zytoplasmakörper bei der Ratte. Allerdings wurde die endokrine Funktion dieser atrialen, spezifisch granulierten Zellen erstmals von Jamieson und Palade (20) postuliert. Gauer und Henry (siehe Zitat 1963, 16) erkannten 1956 ein nerval gesteuertes Reflexgeschehen, nach dem die Dehnung der Herzvorhöfe eine Stimulation der Diurese bewirkt. Dieser kardiorenale Reflex wurde später auch bei Versuchstieren mit denervierten Herzen beobachtet, so daß ein humoraler innervationsunabhängiger Weg der kardiorenalen Interaktion mit in Betracht gezogen werden mußte (23).

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Copyright information

© Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt 1988

Authors and Affiliations

  • W. G. Forssmann
    • 1
    • 2
  • D. Hock
    • 1
  1. 1.Anatomisches InstitutUniversität HeidelbergDeutschland
  2. 2.Anatomisches Institut IIIUniversität HeidelbergHeidelbergDeutschland

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